Annotations: 2LUT

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PTN_MK_C	e2lutA2	A: few secondary structure elements	X: Midkine-related (From Topology)	H: Midkine-related (From Topology)	T: Midkine-related	F: PTN_MK_C	ECOD (1.6)
A	PTN_MK_N	e2lutA1	A: few secondary structure elements	X: Midkine-related (From Topology)	H: Midkine-related (From Topology)	T: Midkine-related	F: PTN_MK_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.20.60.10	Mainly Beta	Single Sheet	Heparin-binding Growth Factor, Midkine	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01091	PTN/MK heparin-binding protein family, C-terminal domain (PTN_MK_C)	PTN/MK heparin-binding protein family, C-terminal domain		Domain
A	PF05196	PTN/MK heparin-binding protein family, N-terminal domain (PTN_MK_N)	PTN/MK heparin-binding protein family, N-terminal domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Midkine-related growth factor	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	developmental process tissue regeneration epithelium development sensory epithelium regeneration developmental growth anatomical structure development growth tissue development regeneration epithelium regeneration cardiac muscle tissue regeneration regulation of biological process regulation of cellular process biological regulation developmental process tissue regeneration epithelium development sensory epithelium regeneration developmental growth anatomical structure development growth tissue development regeneration epithelium regeneration cardiac muscle tissue regeneration regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle positive regulation of biological process positive regulation of cell cycle mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle positive regulation of cellular process positive regulation of cell division cell division regulation of cell division multicellular organismal process embryonic epithelial tube formation chordate embryonic development tube formation embryo development multicellular organism development epithelial tube formation tube morphogenesis embryo development ending in birth or egg hatching epithelial tube morphogenesis system development morphogenesis of embryonic epithelium neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue morphogenesis anatomical structure morphogenesis neural tube formation anatomical structure formation involved in morphogenesis	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020090	Pleiotrophin/Midkine, C-terminal domain	Domain
A	IPR020089	Pleiotrophin/Midkine, N-terminal domain	Domain
A	IPR000762	Midkine heparin-binding growth factor	Family
A	IPR037122	Pleiotrophin/Midkine, N-terminal domain superfamily	Homologous Superfamily
A	IPR020091	Pleiotrophin/Midkine disulphide-rich domain superfamily	Homologous Superfamily
A	IPR038130	Pleiotrophin/Midkine, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.