2OSA | pdb_00002osa

The Rho-GAP domain of human N-chimaerin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2osaa_	All alpha proteins	GTPase activation domain, GAP	GTPase activation domain, GAP	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	BCR-homology GTPase activation domain (RhoGAP-domain)	8079460	4001255	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GTPase activation domain, GAP	8079461	3001163	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RhoGAP	e2osaA1	A: alpha bundles	X: GTPase activation domain, GAP (From Topology)	H: GTPase activation domain, GAP (From Topology)	T: GTPase activation domain, GAP	F: RhoGAP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.555.10	Mainly Alpha	Orthogonal Bundle	Phosphatidylinositol 3-kinase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00620	RhoGAP domain (RhoGAP)	RhoGAP domain	GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	N-chimaerin	protein binding binding signaling receptor binding ephrin receptor binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cation binding transition metal ion binding zinc ion binding protein binding binding signaling receptor binding ephrin receptor binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis regulation of axonogenesis cell differentiation anatomical structure development cellular component organization or biogenesis regulation of anatomical structure morphogenesis system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular process regulation of plasma membrane bounded cell projection organization cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway motor neuron axon guidance axon guidance neuron projection guidance	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR037860	Chimaerin, RhoGAP domain	Domain
A	IPR000198	Rho GTPase-activating protein domain	Domain
A	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR000980	SH2 domain	Domain
A	IPR017356	Chimaerin	Family
A	IPR020454	Diacylglycerol/phorbol-ester binding	Domain
A	IPR051854	Rho-type GTPase-activating protein	Family
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR046349	C1-like domain superfamily	Homologous Superfamily
A	IPR035840	Chimaerin, SH2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P15882	Duane retraction syndrome Duane retraction syndrome 2 pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease pilocytic astrocytoma psoriasis Type 1 Duane Retraction Syndrome astrocytic tumor cutaneous lupus erythematosus large cell medulloblastoma malignant glioma nasopharyngeal carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy Duane retraction syndrome Duane retraction syndrome 2 pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease pilocytic astrocytoma psoriasis Type 1 Duane Retraction Syndrome astrocytic tumor cutaneous lupus erythematosus large cell medulloblastoma malignant glioma nasopharyngeal carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy pituitary cancer Sjogren syndrome ulcerative colitis atypical teratoid rhabdoid tumor lung cancer malignant mesothelioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Pick disease primitive neuroectodermal tumor strabismus breast cancer glioblastoma malignant ependymoma medulloblastoma oligodendroglioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.