2QF4 | pdb_00002qf4

High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (orthorhombic form)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	MreC-like	8090234	3002420	SCOP2B (2022-06-29)
A	SCOP2 Family	MreC-like	8045319	4004409	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	MreC-like	8090234	3002420	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	MreC	e2qf4B1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: MreC	ECOD (1.6)
A	MreC	e2qf4A1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: MreC	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.10.340	Mainly Beta	Beta Barrel	Thrombin, subunit H	Rod shape-determining protein MreC, domain 1	CATH (4.3.0)
B	2.40.10.350	Mainly Beta	Beta Barrel	Thrombin, subunit H	Rod shape-determining protein MreC, domain 2	CATH (4.3.0)
A	2.40.10.340	Mainly Beta	Beta Barrel	Thrombin, subunit H	Rod shape-determining protein MreC, domain 1	CATH (4.3.0)
A	2.40.10.350	Mainly Beta	Beta Barrel	Thrombin, subunit H	Rod shape-determining protein MreC, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF04085	Rod shape-determining protein MreC, barrel core (MreC)	Rod shape-determining protein MreC, barrel core	MreC (murein formation C) is involved in the rod shape determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped [1]. This entry represents the periplasmic core of these proteins which is ...	MreC (murein formation C) is involved in the rod shape determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped [1]. This entry represents the periplasmic core of these proteins which is composed of two six-stranded beta-barrels [1,2]. MreC self-associates into polar filaments [1]. The periplasmic part of MreC contains also a coiled-coil region which is involved in the formation of dimer essential for its function [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cell shape determining protein MreC	-	developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR042177	Cell/Rod shape-determining protein MreC, domain 1	Homologous Superfamily
A, B	IPR055342	Rod shape-determining protein MreC, beta-barrel core	Domain
A, B	IPR007221	Rod shape-determining protein MreC	Family
A, B	IPR042175	Cell/Rod shape-determining protein MreC, domain 2	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.