2WN3

Crystal structure of Discoidin I from Dictyostelium discoideum in complex with the disaccharide GalNAc beta 1-3 galactose, at 1.6 A resolution.

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F5_F8_type_C	e2wn3A2	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: F5_F8_type_C	ECOD (1.6)
A	H_lectin	e2wn3A1	A: beta sandwiches	X: Agglutinin HPA-like	H: Agglutinin HPA-like (From Topology)	T: Agglutinin HPA-like	F: H_lectin	ECOD (1.6)
B	F5_F8_type_C	e2wn3B2	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: F5_F8_type_C	ECOD (1.6)
B	H_lectin	e2wn3B1	A: beta sandwiches	X: Agglutinin HPA-like	H: Agglutinin HPA-like (From Topology)	T: Agglutinin HPA-like	F: H_lectin	ECOD (1.6)
C	F5_F8_type_C	e2wn3C2	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: F5_F8_type_C	ECOD (1.6)
C	H_lectin	e2wn3C1	A: beta sandwiches	X: Agglutinin HPA-like	H: Agglutinin HPA-like (From Topology)	T: Agglutinin HPA-like	F: H_lectin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
A	2.60.40.2080	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
B	2.60.40.2080	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
C	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
C	2.60.40.2080	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00754	F5/8 type C domain (F5_F8_type_C)	F5/8 type C domain	This domain is also known as the discoidin (DS) domain family [1].	Domain
A, B, C	PF09458	H-type lectin domain (H_lectin)	H-type lectin domain	The H-type lectin domain is a unit of six beta chains, combined into a homo-hexamer. It is involved in self/non-self recognition of cells, through binding with carbohydrates [1]. It is sometimes found in association with the F5_F8_type_C domain Pfam: ...	The H-type lectin domain is a unit of six beta chains, combined into a homo-hexamer. It is involved in self/non-self recognition of cells, through binding with carbohydrates [1]. It is sometimes found in association with the F5_F8_type_C domain Pfam:PF00754.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	DISCOIDIN-1 SUBUNIT A	binding lipooligosaccharide binding carbohydrate derivative binding oligosaccharide binding carbohydrate binding N-acetylgalactosamine binding polysaccharide binding	mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process response to phenylpropanoid response to stimulus response to chemical response to oxygen-containing compound response to catechin mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process response to phenylpropanoid response to stimulus response to chemical response to oxygen-containing compound response to catechin response to flavonoid response to organic cyclic compound regulation of protein complex stability biological regulation regulation of biological quality regulation of biosynthetic process regulation of biological process regulation of cellular process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process response to ketone response to curcumin response to ether reproductive process asexual reproduction biological process involved in interspecies interaction between organisms lectin-induced modified bacterial internalization biological process involved in interaction with symbiont biological process involved in symbiotic interaction protein localization localization protein localization to cell periphery cellular localization cellular macromolecule localization macromolecule localization protein localization to cell cortex cellular component organization organelle organization cellular component organization or biogenesis cytoskeleton organization cortical cytoskeleton organization response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus cell adhesion cell-cell adhesion cell-substrate adhesion	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cell surface cytosol membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cell surface cytosol membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle vesicle endocytic vesicle other organism part symbiont cell surface extracellular matrix external encapsulating structure protein-containing complex protein complex involved in cell adhesion

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A, B, C	IPR019019	H-type lectin domain	Domain
A, B, C	IPR052487	Galactose-binding lectin	Family
A, B, C	IPR037221	H-type lectin domain superfamily	Homologous Superfamily
A, B, C	IPR000421	Coagulation factor 5/8, C-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.