2YOQ

Structure of FAM3B PANDER E30 construct

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	FAM3B/PANDER-like	8055727	3002300	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	FAM3B/PANDER-like	8055727	3002300	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	FAM3B/PANDER-like	8055727	3002300	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	ILEI	e2yoqC2	A: a+b two layers	X: FAM3 superfamily (From Topology)	H: FAM3 superfamily (From Topology)	T: FAM3 superfamily	F: ILEI	ECOD (1.6)
A	ILEI	e2yoqA1	A: a+b two layers	X: FAM3 superfamily (From Topology)	H: FAM3 superfamily (From Topology)	T: FAM3 superfamily	F: ILEI	ECOD (1.6)
B	ILEI	e2yoqB1	A: a+b two layers	X: FAM3 superfamily (From Topology)	H: FAM3 superfamily (From Topology)	T: FAM3 superfamily	F: ILEI	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF15711	Interleukin-like EMT inducer (ILEI)	Interleukin-like EMT inducer	ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fib ...	ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localisation, is associated with EMT in human cancerous tissue [1]. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	PROTEIN FAM3B	binding carbohydrate binding protein binding molecular function activator activity signaling receptor binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	cellular process apoptotic process cell death programmed cell death protein localization establishment of protein localization cellular localization nitrogen compound transport transport signaling hormone secretion cell communication protein localization to extracellular region peptide secretion cellular process apoptotic process cell death programmed cell death protein localization establishment of protein localization cellular localization nitrogen compound transport transport signaling hormone secretion cell communication protein localization to extracellular region peptide secretion localization secretion by cell amide transport signal release cellular macromolecule localization regulation of biological quality regulation of biological process secretion regulation of hormone levels biological regulation establishment of protein localization to extracellular region cell-cell signaling export from cell protein secretion establishment of localization peptide transport protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope cellular anatomical structure organelle lumen organelle nuclear envelope lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope cellular anatomical structure organelle lumen organelle nuclear envelope lumen nuclear envelope extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR039477	ILEI/PANDER domain	Domain
A, B, C	IPR039220	FAM3 family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.