2CSE | pdb_00002cse

Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D [auth S]	d2cses1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
E [auth D]	d2csed1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
F [auth E]	d2csee1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
G [auth F]	d2csef1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
H [auth M]	d2csem1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
I [auth N]	d2csen1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
J [auth O]	d2cseo1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
L [auth H]	d2cseh1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
M [auth I]	d2csei1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
K [auth G]	d2cseg1	Alpha and beta proteins (a+b)	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	Outer capsid protein sigma 3	(Mammalian orthoreovirus 1 Lang ) [TaxId: 10884 ],	SCOPe (2.08)
U	d2cseu1	Low resolution protein structures	Reovirus components	Reovirus components	Reovirus components	outer-capsid protein mu1 and reovirus core	(Mammalian orthoreovirus 3 Dearing ) [TaxId: 10886 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
N [auth P]	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
P [auth R]	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
Q [auth J]	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
S [auth L]	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
O [auth Q]	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
R [auth K]	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Reovirus mu1 protein-like	8091411	3002506	SCOP2B (2022-06-29)
D [auth S]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)
E [auth D]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)
F [auth E]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)
G [auth F]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)
H [auth M]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)
I [auth N]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)
J [auth O]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)
L [auth H]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)
M [auth I]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)
K [auth G]	SCOP2B Superfamily	Outer capsid protein sigma 3	8071741	3001282	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Reovirus_M2_2nd	e2cseA2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
A	Reovirus_M2_3rd	e2cseA3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
A	Reovirus_M2_1st	e2cseA1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
B	Reovirus_M2_2nd	e2cseB2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
B	Reovirus_M2_3rd	e2cseB3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
B	Reovirus_M2_1st	e2cseB1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
C	Reovirus_M2_2nd	e2cseC2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
C	Reovirus_M2_3rd	e2cseC3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
C	Reovirus_M2_1st	e2cseC1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
N [auth P]	Reovirus_M2_2nd	e2cseP2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
N [auth P]	Reovirus_M2_3rd	e2cseP3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
N [auth P]	Reovirus_M2_1st	e2cseP1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
P [auth R]	Reovirus_M2_2nd	e2cseR2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
P [auth R]	Reovirus_M2_3rd	e2cseR3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
P [auth R]	Reovirus_M2_1st	e2cseR1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
Q [auth J]	Reovirus_M2_2nd	e2cseJ2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
Q [auth J]	Reovirus_M2_3rd	e2cseJ3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
Q [auth J]	Reovirus_M2_1st	e2cseJ1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
S [auth L]	Reovirus_M2_2nd	e2cseL2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
S [auth L]	Reovirus_M2_3rd	e2cseL3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
S [auth L]	Reovirus_M2_1st	e2cseL1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
O [auth Q]	Reovirus_M2_2nd	e2cseQ2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
O [auth Q]	Reovirus_M2_3rd	e2cseQ3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
O [auth Q]	Reovirus_M2_1st	e2cseQ1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
R [auth K]	Reovirus_M2_2nd	e2cseK2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
R [auth K]	Reovirus_M2_3rd	e2cseK3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
R [auth K]	Reovirus_M2_1st	e2cseK1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
T	Reovirus_M2_2nd	e2cseT2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in membrane penetration protein mu1 (From Topology)	T: Jelly-roll domain in membrane penetration protein mu1	F: Reovirus_M2_2nd	ECOD (1.6)
T	Reovirus_M2_3rd	e2cseT3	A: alpha arrays	X: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	H: Alpha-helical domain in membrane penetration protein mu1 (From Topology)	T: Alpha-helical domain in membrane penetration protein mu1	F: Reovirus_M2_3rd	ECOD (1.6)
T	Reovirus_M2_1st	e2cseT1	A: a+b complex topology	X: a+b domain in membrane penetration protein mu1 (From Topology)	H: a+b domain in membrane penetration protein mu1 (From Topology)	T: a+b domain in membrane penetration protein mu1	F: Reovirus_M2_1st	ECOD (1.6)
D [auth S]	Reovirus_cap	e2cseS1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
E [auth D]	Reovirus_cap	e2cseD1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
F [auth E]	Reovirus_cap	e2cseE1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
G [auth F]	Reovirus_cap	e2cseF1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
H [auth M]	Reovirus_cap	e2cseM1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
I [auth N]	Reovirus_cap	e2cseN1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
J [auth O]	Reovirus_cap	e2cseO1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
L [auth H]	Reovirus_cap	e2cseH1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
M [auth I]	Reovirus_cap	e2cseI1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
K [auth G]	Reovirus_cap	e2cseG1	A: a+b complex topology	X: Outer capsid protein sigma 3-related (From Topology)	H: Outer capsid protein sigma 3-related (From Topology)	T: Outer capsid protein sigma 3-related	F: Reovirus_cap	ECOD (1.6)
U	Reovirus_L2_6th	e2cseU1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Reovirus_L2_6th	ECOD (1.6)
U	Reovirus_L2_7th	e2cseU2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Reovirus_L2_7th	ECOD (1.6)
U	Reovirus_L2_8th_1	e2cseU3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Reovirus_L2_8th_1	ECOD (1.6)
U	Reovirus_L2_4th	e2cseU4	A: a+b two layers	X: ferredoxin-like domain in VP1 (From Topology)	H: ferredoxin-like domain in VP1 (From Topology)	T: ferredoxin-like domain in VP1	F: Reovirus_L2_4th	ECOD (1.6)
U	Reovirus_L2_2nd	e2cseU5	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: Reovirus_L2_2nd	ECOD (1.6)
U	Reovirus_L2_1st	e2cseU6	A: a+b complex topology	X: Rotavirus NSP2 fragment, N-terminal domain (From Topology)	H: Rotavirus NSP2 fragment, N-terminal domain (From Topology)	T: Rotavirus NSP2 fragment, N-terminal domain	F: Reovirus_L2_1st	ECOD (1.6)
U	Reovirus_L2_3rd	e2cseU7	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Reovirus_L2_3rd	ECOD (1.6)
U	Reovirus_L2_5th	e2cseU8	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Reovirus_L2_5th	ECOD (1.6)
V	lambda-1	e2cseV1	A: a+b complex topology	X: Inner layer core protein p3-related (From Topology)	H: Inner layer core protein p3-related (From Topology)	T: Inner layer core protein p3-related	F: lambda-1	ECOD (1.6)
W	lambda-1,zf-C2H2_6	e2cseW1	A: a+b complex topology	X: Inner layer core protein p3-related (From Topology)	H: Inner layer core protein p3-related (From Topology)	T: Inner layer core protein p3-related	F: lambda-1,zf-C2H2_6	ECOD (1.6)
X	Sigma_1_2	e2cseX1	A: alpha complex topology	X: Core protein VP6 (From Topology)	H: Core protein VP6 (From Topology)	T: Core protein VP6	F: Sigma_1_2	ECOD (1.6)
Y	Sigma_1_2	e2cseY1	A: alpha complex topology	X: Core protein VP6 (From Topology)	H: Core protein VP6 (From Topology)	T: Core protein VP6	F: Sigma_1_2	ECOD (1.6)
Z	Sigma_1_2	e2cseZ1	A: alpha complex topology	X: Core protein VP6 (From Topology)	H: Core protein VP6 (From Topology)	T: Core protein VP6	F: Sigma_1_2	ECOD (1.6)
AA [auth 1]	RdRP_5_3rd	e2cse11	A: alpha bundles	X: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	T: helical bundle domain in reverse transcriptase-like polymerases	F: RdRP_5_3rd	ECOD (1.6)
AA [auth 1]	RdRP_5_4th	e2cse14	A: alpha complex topology	X: C-terminal additional helical subdomain in reovirus polymerase lambda3 (From Topology)	H: C-terminal additional helical subdomain in reovirus polymerase lambda3 (From Topology)	T: C-terminal additional helical subdomain in reovirus polymerase lambda3	F: RdRP_5_4th	ECOD (1.6)
AA [auth 1]	RdRP_5_1st	e2cse12	A: alpha complex topology	X: N-terminal additional helical subdomain in reovirus polymerase lambda3 (From Homology)	H: N-terminal additional helical subdomain in reovirus polymerase lambda3	T: N-terminal additional helical subdomain in reovirus polymerase lambda3	F: RdRP_5_1st	ECOD (1.6)
AA [auth 1]	RdRP_5_2nd	e2cse13	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: RdRP_5_2nd	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D [auth S], E [auth D], F [auth E], G [auth F], H [auth M], D [auth S], E [auth D], F [auth E], G [auth F], H [auth M], I [auth N], J [auth O], K [auth G], L [auth H], M [auth I]	PF00979	Reovirus outer capsid protein, Sigma 3 (Reovirus_cap)	Reovirus outer capsid protein, Sigma 3	-	Family
U	PF21064	Reovirus core-spike protein lambda-2 (L2), N-terminal (Reovirus_L2_N)	Reovirus core-spike protein lambda-2 (L2), N-terminal	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight dom ...	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight domains with the most N-terminal domain at the base of the turret and the most C-terminal domain at the top [2]. This entry represents the N-terminal domain which adopts an alpha/beta topology.	Domain
U	PF21063	Reovirus core-spike protein lambda-2 (L2), GTase domain (Reovirus_L2_GTase)	Reovirus core-spike protein lambda-2 (L2), GTase domain	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight dom ...	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight domains with the most N-terminal domain at the base of the turret and the most C-terminal domain at the top. This entry represents the second one, which contains the nucleotide-binding histidine triad (HIT)-like motif from the GTase (guanylyltransferase) domain [2].	Domain
U	PF21066	Reovirus core-spike protein lambda-2 (L2), methyltransferase-2 (Reovirus_L2_MT2)	Reovirus core-spike protein lambda-2 (L2), methyltransferase-2	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight dom ...	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight domains with the most N-terminal domain at the base of the turret and the most C-terminal domain at the top. This entry represents the second methyltransferase domain (MT2), which catalyses the last reaction, 2'O-methylation [2].	Domain
U	PF21065	Reovirus core-spike protein lambda-2 (L2), methyltransferase-1 (Reovirus_L2_MT1)	Reovirus core-spike protein lambda-2 (L2), methyltransferase-1	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight dom ...	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight domains with the most N-terminal domain at the base of the turret and the most C-terminal domain at the top. This entry represents the methyltransferase-1 domain [2] which adds a methyl group to the N7 of the guanosine added by the GTase [2].	Domain
U	PF21060	Reovirus core-spike protein lambda-2 (L2), 6th domain (Reovirus_L2_6th)	Reovirus core-spike protein lambda-2 (L2), 6th domain	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight dom ...	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight domains with the most N-terminal domain at the base of the turret and the most C-terminal domain at the top. This entry represents the sixth domain which, together with the seventh and eighth (Pfam:PF06016) domains forms a three-domain flap at the top of the turret, that may serve as a gate to retard exit of the 5' terminus of the mRNA [2]. This domain has a Ig-like fold, resembling the V of an antibody light chain [2].	Domain
U	PF21062	Reovirus core-spike protein lambda-2 (L2), ferredoxin-like domain (Reovirus_L2_4th)	Reovirus core-spike protein lambda-2 (L2), ferredoxin-like domain	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight dom ...	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight domains with the most N-terminal domain at the base of the turret and the most C-terminal domain at the top. This entry represents the fourth domain, which adopts a ferredoxin-like fold consisting of four beta-strands protected by alpha-helices that probably functions as a structural support for the three enzyme domains (two methyltransferase and GTase domains) [2].	Domain
U	PF06016	Reovirus core-spike protein lambda-2 (L2), C-terminal (Reovirus_L2_8th)	Reovirus core-spike protein lambda-2 (L2), C-terminal	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight dom ...	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight domains with the most N-terminal domain at the base of the turret and the most C-terminal domain at the top. This entry represents the C-terminal (eighth) domain which, together with the sixth and seventh domains, forms a three-domain flap at the top of the turret, that may serve as a gate to retard exit of the 5' terminus of the mRNA [2]. This domain has a Ig-like, resembling a truncated V region of an antibody light chain.	Domain
U	PF21061	Reovirus core-spike protein lambda-2 (L2), 7th domain (Reovirus_L2_7th)	Reovirus core-spike protein lambda-2 (L2), 7th domain	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight dom ...	Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1]. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight domains with the most N-terminal domain at the base of the turret and the most C-terminal domain at the top. This entry represents the seventh domain which, together with the sixth (Pfam:PF21060) and eighth (Pfam:PF06016) domains forms a three-domain flap at the top of the turret, that may serve as a gate to retard exit of the 5' terminus of the mRNA [2]. This domain has a Ig-like fold, resembling the C region of an antibody light chain [2].	Domain
V, W	PF22033	Inner capsid protein lambda-1/VP3 (Lamba1_VP3)	Inner capsid protein lambda-1/VP3	The reovirus inner capsid protein lambda-1 displays nucleoside triphosphate phosphohydrolase (NTPase),RNA-5'-triphosphatase (RTPase), and RNA helicase activity and may play a role in the transcription of the virus genome, the unwinding or reannealing ...	The reovirus inner capsid protein lambda-1 displays nucleoside triphosphate phosphohydrolase (NTPase),RNA-5'-triphosphatase (RTPase), and RNA helicase activity and may play a role in the transcription of the virus genome, the unwinding or reannealing of double-stranded RNA during RNA synthesis. Lambda1 is an Orthoreovirus core protein, VP3 is the homologous core protein in Aquareoviruses [1-4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, N [auth P], O [auth Q], A, B, C, N [auth P], O [auth Q], P [auth R], Q [auth J], R [auth K], S [auth L], T	major outer-capsid protein mu1	host cell surface binding binding	symbiont-mediated disruption of host anatomical structure biological process involved in interspecies interaction between organisms symbiont entry into host cell via permeabilization of host membrane viral life cycle symbiont-mediated disruption of host cellular anatomical structure biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host membrane symbiont entry into host cell viral process symbiont entry into host disruption of anatomical structure in another organism	cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle host cell mitochondrion viral capsid virion component cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle host cell mitochondrion viral capsid virion component host cell plasma membrane host cell membrane icosahedral viral capsid viral outer capsid
D [auth S], E [auth D], F [auth E], G [auth F], H [auth M], D [auth S], E [auth D], F [auth E], G [auth F], H [auth M], I [auth N], J [auth O], K [auth G], L [auth H], M [auth I]	major capsid surface protein sigma-3	protein serine/threonine kinase activity enzyme regulator activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity enzyme inhibitor activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity catalytic activity protein serine/threonine kinase activity enzyme regulator activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity enzyme inhibitor activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity catalytic activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity structural molecule activity RNA binding binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	viral process viral life cycle regulation of biosynthetic process regulation of biological process regulation of cellular process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression viral process viral life cycle regulation of biosynthetic process regulation of biological process regulation of cellular process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process protein metabolic process regulation of metabolic process symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host defenses symbiont-mediated suppression of host PKR/eIFalpha signaling symbiont-mediated response to host defenses response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host process symbiont-mediated suppression of host-directed shutoff of host translation symbiont-mediated suppression of host defenses response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host defense response symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host innate immune response symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host type I interferon-mediated signaling pathway	viral capsid icosahedral viral capsid virion component viral outer capsid
U	guanylyltransferase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding guanylyltransferase activity mRNA guanylyltransferase activity RNA guanylyltransferase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid transferase activity catalytic activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups RNA methyltransferase activity transferase activity, transferring one-carbon groups S-adenosylmethionine-dependent methyltransferase activity mRNA 5'-cap (guanine-N7-)-methyltransferase activity N-methyltransferase activity methyltransferase activity mRNA methyltransferase activity guanyl nucleotide binding GTP binding guanyl ribonucleotide binding	-	viral capsid icosahedral viral capsid virion component viral outer capsid
V, W	major core protein lambda 1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity cohesin loader activity DNA clamp loader activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides ATP-dependent H2AZ histone chaperone activity nucleic acid conformation isomerase activity isomerase activity catalytic activity, acting on RNA helicase activity RNA helicase activity ATP-dependent activity, acting on RNA macromolecular conformation isomerase activity cation binding metal ion binding	7-methylguanosine mRNA capping RNA metabolic process primary metabolic process 7-methylguanosine RNA capping RNA capping gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process mRNA processing mRNA metabolic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process 7-methylguanosine mRNA capping RNA metabolic process primary metabolic process 7-methylguanosine RNA capping RNA capping gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process mRNA processing mRNA metabolic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process RNA 5'-end processing metabolic process cellular process RNA processing macromolecule metabolic process	viral capsid icosahedral viral capsid virion component viral inner capsid
X, Y, Z	Sigma 2 protein	-	-	viral capsid icosahedral viral capsid virion component viral inner capsid
AA [auth 1]	Minor core protein lambda 3	RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups RNA binding binding nucleic acid binding nucleoside phosphate binding nucleotide binding RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups RNA binding binding nucleic acid binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding	viral genome replication viral process viral life cycle	viral nucleocapsid viral capsid virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, N [auth P], O [auth Q], A, B, C, N [auth P], O [auth Q], P [auth R], Q [auth J], R [auth K], S [auth L], T	IPR015961	Mu1 membrane penetration protein, domain I	Homologous Superfamily
A, B, C, N [auth P], O [auth Q], A, B, C, N [auth P], O [auth Q], P [auth R], Q [auth J], R [auth K], S [auth L], T	IPR015960	Mu1 membrane penetration protein, domain IV	Homologous Superfamily
A, B, C, N [auth P], O [auth Q], A, B, C, N [auth P], O [auth Q], P [auth R], Q [auth J], R [auth K], S [auth L], T	IPR036256	Mu1/VP4 superfamily	Homologous Superfamily
A, B, C, N [auth P], O [auth Q], A, B, C, N [auth P], O [auth Q], P [auth R], Q [auth J], R [auth K], S [auth L], T	IPR009113	Outer capsid protein Mu1/VP4	Family
A, B, C, N [auth P], O [auth Q], A, B, C, N [auth P], O [auth Q], P [auth R], Q [auth J], R [auth K], S [auth L], T	IPR015962	Mu1 membrane penetration protein, domain II	Homologous Superfamily
A, B, C, N [auth P], O [auth Q], A, B, C, N [auth P], O [auth Q], P [auth R], Q [auth J], R [auth K], S [auth L], T	IPR044937	Mu1 membrane penetration protein, domain III	Homologous Superfamily
D [auth S], E [auth D], F [auth E], G [auth F], H [auth M], D [auth S], E [auth D], F [auth E], G [auth F], H [auth M], I [auth N], J [auth O], K [auth G], L [auth H], M [auth I]	IPR000153	Reovirus, outer capsid sigma 3	Family
D [auth S], E [auth D], F [auth E], G [auth F], H [auth M], D [auth S], E [auth D], F [auth E], G [auth F], H [auth M], I [auth N], J [auth O], K [auth G], L [auth H], M [auth I]	IPR023634	Reovirus, outer capsid sigma-3 domain superfamily	Homologous Superfamily
U	IPR048601	Reovirus core-spike protein lambda-2-like, GTase domain	Domain
U	IPR048602	Reovirus core-spike protein lambda-2-like, 7th domain	Domain
U	IPR048604	Reovirus core-spike protein lambda-2-like, ferredoxin-like domain	Domain
U	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
U	IPR048598	Reovirus core-spike protein lambda-2-like, first methyltransferase domain	Domain
U	IPR048596	Reovirus core-spike protein lambda-2-like, N-terminal domain	Domain
U	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
U	IPR048603	Reovirus core-spike protein lambda-2-like, 6th domain	Domain
U	IPR010311	Reovirus core-spike lambda-2	Family
U	IPR048597	Reovirus core-spike protein lambda-2-like, second methyltransferase domain	Domain
U	IPR048294	Reovirus core-spike protein lambda-2-like, C-terminal domain	Domain
V, W	IPR044949	Inner capsid protein lambda-1/ VP3 superfamily	Homologous Superfamily
V, W	IPR013087	Zinc finger C2H2-type	Domain
V, W	IPR054176	Inner capsid protein lambda-1/VP3	Domain
X, Y, Z	IPR004317	Sigma1/sigma2, reoviral	Family
AA [auth 1]	IPR007097	RNA-directed RNA polymerase, reovirus	Domain
AA [auth 1]	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
AA [auth 1]	IPR012915	Reovirus RNA-dependent RNA polymerase lambda 3	Family