2JM2 | pdb_00002jm2

Structure of the N-terminal subdomain of insulin-like growth factor (IGF) binding protein-6 and its interactions with IGFs

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Insulin-like growth factor-binding protein 6	protein binding binding signaling receptor binding fibronectin binding insulin-like growth factor binding insulin-like growth factor II binding growth factor binding insulin-like growth factor I binding identical protein binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of cellular response to stress positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus stress-activated MAPK cascade cellular response to stress regulation of intracellular signal transduction cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of cellular response to stress positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus stress-activated MAPK cascade cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress intracellular signaling cassette signal transduction positive regulation of stress-activated protein kinase signaling cascade positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of stress-activated MAPK cascade positive regulation of MAPK cascade biological regulation regulation of stress-activated protein kinase signaling cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade regulation of response to stimulus MAPK cascade regulation of cell communication cellular process positive regulation of signaling negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway regulation of insulin-like growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of cell communication negative regulation of Wnt signaling pathway Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway cell migration cell motility	cellular anatomical structure extracellular region insulin-like growth factor binary complex protein-containing complex extracellular space insulin-like growth factor binding protein complex growth factor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata	Family
A	IPR022326	Insulin-like growth factor-binding protein 6	Family
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR036857	Thyroglobulin type-1 superfamily	Homologous Superfamily
A	IPR000716	Thyroglobulin type-1	Domain
A	IPR000867	Insulin-like growth factor-binding protein, IGFBP	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P24592	adult acute respiratory distress syndrome endometriosis prostate cancer contact dermatitis malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Prostatic Neoplasms spina bifida adrenal cortex carcinoma breast carcinoma large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma adult acute respiratory distress syndrome endometriosis prostate cancer contact dermatitis malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Prostatic Neoplasms spina bifida adrenal cortex carcinoma breast carcinoma large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer psoriasis breast fibroadenoma cystic fibrosis lung adenocarcinoma malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm sarcoidosis adrenal cortex adenoma breast cancer ductal breast carcinoma in situ invasive ductal breast carcinoma malignant colon neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.