3AQG | pdb_00003aqg

Crystal structure of human pancreatic secretory protein ZG16b

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Jacalin	e3aqgB1	A: beta duplicates or obligate multimers	X: beta-Prism I (From Topology)	H: beta-Prism I (From Topology)	T: beta-Prism I	F: Jacalin	ECOD (1.6)
A	Jacalin	e3aqgA1	A: beta duplicates or obligate multimers	X: beta-Prism I (From Topology)	H: beta-Prism I (From Topology)	T: beta-Prism I	F: Jacalin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.100.10.30	Mainly Beta	Aligned Prism	Vitelline Membrane Outer Layer Protein I, subunit A	Jacalin-like lectin domain	CATH (4.3.0)
A	2.100.10.30	Mainly Beta	Aligned Prism	Vitelline Membrane Outer Layer Protein I, subunit A	Jacalin-like lectin domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01419	Jacalin-like lectin domain (Jacalin)	Jacalin-like lectin domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Zymogen granule protein 16 homolog B	binding carbohydrate binding	cell migration cellular process cell motility	cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm extracellular region extracellular space apicolateral plasma membrane plasma membrane region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm extracellular region extracellular space apicolateral plasma membrane plasma membrane region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036404	Jacalin-like lectin domain superfamily	Homologous Superfamily
A, B	IPR052321	Polyamine Binding and Protein Trafficking	Family
A, B	IPR001229	Jacalin-like lectin domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q96DA0	adrenal cortex carcinoma breast fibroadenoma ductal breast carcinoma in situ lung cancer pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis atopic eczema Crohn disease interstitial cystitis malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma psoriasis breast carcinoma cystic fibrosis adrenal cortex carcinoma breast fibroadenoma ductal breast carcinoma in situ lung cancer pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis atopic eczema Crohn disease interstitial cystitis malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma psoriasis breast carcinoma cystic fibrosis invasive ductal breast carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm sinusitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.