Annotations: 3BPZ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3bpza_	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	cAMP-binding domain	HCN pacemaker channel	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d3bpzb_	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	cAMP-binding domain	HCN pacemaker channel	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d3bpzd_	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	cAMP-binding domain	HCN pacemaker channel	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d3bpzc_	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	cAMP-binding domain	HCN pacemaker channel	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	cAMP-binding domain-like	8039776	3000084	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	cAMP-binding domain-like	8039776	3000084	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	cAMP-binding domain-like	8039776	3000084	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	cAMP-binding domain-like	8039776	3000084	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	cNMP_binding_1	e3bpzA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
B	cNMP_binding_1	e3bpzB1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
D	cNMP_binding_1	e3bpzD1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
C	cNMP_binding_1	e3bpzC1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.630	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
A	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
B	1.10.287.630	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
B	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
D	1.10.287.630	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
D	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
C	1.10.287.630	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
C	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00027	Cyclic nucleotide-binding domain (cNMP_binding)	Cyclic nucleotide-binding domain	This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity binding adenyl ribonucleotide binding cyclic nucleotide binding nucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding cAMP binding adenyl nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding intracellularly ligand-gated monoatomic ion channel activity gated channel activity intracellularly cyclic nucleotide-activated monoatomic cation channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity intracellularly cAMP-activated cation channel activity ligand-gated monoatomic cation channel activity cyclic nucleotide-activated monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity voltage-gated potassium channel activity identical protein binding protein binding	transmembrane transport localization nitrogen compound transport transport ammonium transmembrane transport cellular process inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport import into cell monoatomic ion transmembrane transport import across plasma membrane sodium ion import across plasma membrane sodium ion transmembrane transport transmembrane transport localization nitrogen compound transport transport ammonium transmembrane transport cellular process inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport import into cell monoatomic ion transmembrane transport import across plasma membrane sodium ion import across plasma membrane sodium ion transmembrane transport inorganic cation import across plasma membrane metal ion transport monoatomic cation transmembrane transport inorganic ion import across plasma membrane monoatomic ion transport monoatomic cation transport sodium ion transport potassium ion transmembrane transport potassium ion transport biological regulation regulation of biological quality regulation of membrane potential potassium ion import across plasma membrane cellular response to nitrogen compound cellular response to stimulus response to stimulus response to organophosphorus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical cellular response to cAMP response to organic cyclic compound cellular response to cGMP response to cGMP	cellular anatomical structure membrane voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex HCN channel complex plasma membrane potassium channel complex membrane protein complex cation channel complex transporter complex cell periphery transmembrane transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR005821	Ion transport domain	Domain
A, B, C, D	IPR051413	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel	Family
A, B, C, D	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG-like	Family
A, B, C, D	IPR000595	Cyclic nucleotide-binding domain	Domain
A, B, C, D	IPR013621	Ion transport N-terminal	Domain
A, B, C, D	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A, B, C, D	IPR018488	Cyclic nucleotide-binding, conserved site	Conserved Site
A, B, C, D	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.