3BRD | pdb_00003brd

CSL (Lag-1) bound to DNA with Lin-12 RAM peptide, P212121

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d3brda1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	DNA-binding protein LAG-1 (CSL)	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
C [auth A]	d3brda2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	DNA-binding protein LAG-1 (CSL)	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
C [auth A]	d3brda3	All beta proteins	beta-Trefoil	DNA-binding protein LAG-1 (CSL)	DNA-binding protein LAG-1 (CSL)	DNA-binding protein LAG-1 (CSL)	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	DNA-binding protein LAG-1 (CSL)	8027068	4001676	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Family	DNA-binding protein LAG-1 (CSL)	8027069	4001794	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Family	NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain-like	8054882	4007562	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	p53-like transcription factors	8039447	3000758	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	DNA-binding protein LAG-1 (CSL)	8039448	3000391	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	E set domains	8054883	3000070	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	TIG_7	e3brdA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: TIG_7	ECOD (1.6)
C [auth A]	LAG1-DNAbind	e3brdA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: LAG1-DNAbind	ECOD (1.6)
C [auth A]	BTD	e3brdA3	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: BTD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	2.60.40.1450	Mainly Beta	Sandwich	Immunoglobulin-like	LAG1, DNA binding domain	CATH (4.3.0)
C [auth A]	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
C [auth A]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF20144	TIG domain (TIG_SUH)	TIG domain	This entry represents a TIG-like domain found in the suppressor of hairless protein.	Domain
C [auth A]	PF09270	Beta-trefoil DNA-binding domain (BTD)	Beta-trefoil DNA-binding domain	Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and ...	Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR) [1].	Domain
C [auth A]	PF09271	LAG1, DNA binding (LAG1-DNAbind)	LAG1, DNA binding	Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding [1]. Th ...	Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding [1]. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	DNA (5'-D(DTPDTPDAPDCPDTPDGPDTPDGPDGPDGPDAPDAPDAPDGP*DA)-3')	-	-	-
B [auth C]	DNA (5'-D(DAPDAPDTPDCPDTPDTPDTPDCPDCPDCPDAPDCPDAPDGP*DT)-3')	-	-	-
C [auth A]	Lin-12 and glp-1 phenotype protein 1, isoform a	protein binding binding signaling receptor binding Notch binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding binding signaling receptor binding Notch binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity transcription factor binding transcription coregulator binding transcription coactivator binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development cellular developmental process cell differentiation cellular process cell fate specification cell fate commitment regulation of cellular process mesodermal cell differentiation developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development cellular developmental process cell differentiation cellular process cell fate specification cell fate commitment regulation of cellular process mesodermal cell differentiation regulation of developmental process mesoderm morphogenesis regulation of cell differentiation embryo development regulation of mesodermal cell fate specification regulation of mesodermal cell differentiation mesodermal cell fate commitment animal organ morphogenesis mesoderm formation regulation of anatomical structure morphogenesis mesoderm development mesodermal cell fate specification regulation of biological process formation of primary germ layer regulation of animal organ morphogenesis regulation of cell fate commitment biological regulation embryonic morphogenesis animal organ development tissue development gastrulation tissue morphogenesis anatomical structure morphogenesis cell fate commitment involved in formation of primary germ layer regulation of cell fate specification anatomical structure formation involved in morphogenesis behavior egg-laying behavior reproductive process multicellular organismal reproductive process reproductive behavior dauer larval development dauer exit exit from diapause dormancy process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of miRNA transcription cell fate determination sexual reproduction developmental cell growth developmental growth growth oogenesis cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction female gamete generation cell growth gamete generation oocyte development germ cell development oocyte growth oocyte differentiation stem cell division germ-line stem cell division cell division vulval development regulation of vulval development positive regulation of vulval development positive regulation of developmental process transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication Notch signaling pathway signal transduction cellular component organization cell projection morphogenesis cell projection organization cellular component organization or biogenesis cell morphogenesis positive regulation of transcription by RNA polymerase II stem cell fate commitment stem cell differentiation stem cell fate determination	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome CSL-Notch-Mastermind transcription factor complex
D	Protein lin-12	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding molecular transducer activity transmembrane signaling receptor activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development cellular developmental process cell differentiation cellular process cell fate specification cell fate commitment regulation of cellular process mesodermal cell differentiation developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development cellular developmental process cell differentiation cellular process cell fate specification cell fate commitment regulation of cellular process mesodermal cell differentiation regulation of developmental process mesoderm morphogenesis regulation of cell differentiation embryo development regulation of mesodermal cell fate specification regulation of mesodermal cell differentiation mesodermal cell fate commitment animal organ morphogenesis mesoderm formation regulation of anatomical structure morphogenesis mesoderm development mesodermal cell fate specification regulation of biological process formation of primary germ layer regulation of animal organ morphogenesis regulation of cell fate commitment biological regulation embryonic morphogenesis animal organ development tissue development gastrulation tissue morphogenesis anatomical structure morphogenesis cell fate commitment involved in formation of primary germ layer regulation of cell fate specification anatomical structure formation involved in morphogenesis behavior egg-laying behavior reproductive process multicellular organismal reproductive process reproductive behavior dauer larval development dauer exit exit from diapause dormancy process positive regulation of biological process positive regulation of developmental process positive regulation of mesodermal cell fate specification positive regulation of cell differentiation positive regulation of cell fate specification positive regulation of cell fate commitment positive regulation of mesodermal cell differentiation positive regulation of cellular process sleep vulval development positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of vulval development regulation of cellular component organization extracellular matrix organization cellular component organization cellular component organization or biogenesis regulation of basement membrane organization regulation of extracellular matrix organization extracellular structure organization external encapsulating structure organization basement membrane organization cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication Notch signaling pathway signal transduction cell projection morphogenesis cell projection organization cell morphogenesis	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle cell periphery apical part of cell membrane RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane CSL-Notch-Mastermind transcription factor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR037095	RBP-J/Cbf11, DNA binding domain superfamily	Homologous Superfamily
C [auth A]	IPR015350	Beta-trefoil DNA-binding domain	Domain
C [auth A]	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
C [auth A]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
C [auth A]	IPR015351	RBP-J/Cbf11/Cbf12, DNA binding	Domain
C [auth A]	IPR040159	Suppressor of hairless-like	Family
C [auth A]	IPR036358	Beta-trefoil domain superfamily	Homologous Superfamily
C [auth A]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth A]	IPR038007	RBP-Jkappa, IPT domain	Domain
D	IPR010660	Notch, NOD domain	Domain
D	IPR013111	EGF-like domain, extracellular	Domain
D	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
D	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
D	IPR051022	Notch Signaling and Cell Fate Determination	Family
D	IPR000800	Notch domain	Domain
D	IPR013032	EGF-like, conserved site	Conserved Site
D	IPR000742	EGF-like domain	Domain
D	IPR002110	Ankyrin repeat	Repeat
D	IPR049883	NOTCH1 EGF-like calcium-binding domain	Domain
D	IPR035993	Notch-like domain superfamily	Homologous Superfamily
D	IPR011656	Notch, NODP domain	Domain
D	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
D	IPR001881	EGF-like calcium-binding domain	Domain
D	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM