3IEZ | pdb_00003iez

Crystal structure of the RasGAP C-terminal (RGC) domain of IQGAP2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3iezb_	Alpha and beta proteins (a+b)	RGC domain-like	RGC domain-like	RGC domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3ieza_	Alpha and beta proteins (a+b)	RGC domain-like	RGC domain-like	RGC domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	RGC domain-like	8054339	3000236	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	RGC domain-like	8054339	3000236	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	KOG2128	e3iezB1	A: a+b complex topology	X: RGC domain (From Topology)	H: RGC domain (From Topology)	T: RGC domain	F: KOG2128	ECOD (1.6)
A	KOG2128	e3iezA1	A: a+b complex topology	X: RGC domain (From Topology)	H: RGC domain (From Topology)	T: RGC domain	F: KOG2128	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Ras GTPase-activating-like protein IQGAP2	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity GTPase inhibitor activity molecular function inhibitor activity enzyme inhibitor activity ion binding phosphatidylinositol-3,4,5-trisphosphate binding anion binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding calmodulin binding Arp2/3 complex binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication thrombin-activated receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication thrombin-activated receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization cellular component organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization assembly of actomyosin apparatus involved in cytokinesis mitotic actomyosin contractile ring assembly cytoskeleton-dependent cytokinesis mitotic cytokinetic process actomyosin contractile ring assembly mitotic cytokinesis mitotic cell cycle cellular component biogenesis actomyosin contractile ring assembly actin filament organization cellular component assembly cortical actin cytoskeleton organization cell cycle cell cycle process assembly of actomyosin apparatus involved in mitotic cytokinesis actomyosin structure organization cortical cytoskeleton organization actin filament organization cytokinesis mitotic actomyosin contractile ring assembly actin filament organization mitotic cell cycle process cytokinetic process actomyosin contractile ring organization cell division supramolecular fiber organization Arp2/3 complex-mediated actin nucleation actin nucleation	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery cell cortex intracellular anatomical structure cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery cell cortex intracellular anatomical structure cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton cell surface cytosol plasma membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle organelle membrane secretory granule membrane actin-based cell projection microvillus filopodium polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001715	Calponin homology domain	Domain
A, B	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A, B	IPR000048	IQ motif, EF-hand binding site	Binding Site
A, B	IPR001936	Ras GTPase-activating domain	Domain
A, B	IPR023152	Ras GTPase-activating protein, conserved site	Conserved Site
A, B	IPR000593	RasGAP protein, C-terminal	Domain
A, B	IPR036872	CH domain superfamily	Homologous Superfamily
A, B	IPR001202	WW domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q13576	Malignant neoplasm of brain non-small cell lung carcinoma pilocytic astrocytoma astrocytic tumor esophageal adenocarcinoma interstitial cystitis lung cancer malignant ependymoma medulloblastoma osteosarcoma ulcerative colitis atypical teratoid rhabdoid tumor brain cancer breast cancer glioblastoma Malignant neoplasm of brain non-small cell lung carcinoma pilocytic astrocytoma astrocytic tumor esophageal adenocarcinoma interstitial cystitis lung cancer malignant ependymoma medulloblastoma osteosarcoma ulcerative colitis atypical teratoid rhabdoid tumor brain cancer breast cancer glioblastoma large cell medulloblastoma lung carcinoma malignant glioma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor B-cell chronic lymphocytic leukemia diabetes mellitus hepatocellular carcinoma malignant colon neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.