3JQE

Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (DX8)


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilySDR-like 8099562 3000038 SCOP2B (2022-06-29)
ASCOP2B SuperfamilySDR-like 8099562 3000038 SCOP2B (2022-06-29)
CSCOP2B SuperfamilySDR-like 8099562 3000038 SCOP2B (2022-06-29)
DSCOP2B SuperfamilySDR-like 8099562 3000038 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
Badh_short_C2e3jqeB1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Aadh_short_C2e3jqeA1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Cadh_short_C2e3jqeC1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Dadh_short_C2e3jqeD1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF13561Enoyl-(Acyl carrier protein) reductase (adh_short_C2)Enoyl-(Acyl carrier protein) reductaseThis domain is found in Enoyl-(Acyl carrier protein) reductases.Domain