Annotations: 3KO1

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cpn60_TCP1_1st	e3ko1A1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
A	Cpn60_TCP1_2nd	e3ko1A3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd	ECOD (1.6)
A	Cpn60_TCP1_2nd_1	e3ko1A2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_2nd_1	ECOD (1.6)
D	Cpn60_TCP1_1st	e3ko1D1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
D	Cpn60_TCP1_2nd	e3ko1D3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd	ECOD (1.6)
D	Cpn60_TCP1_2nd_1	e3ko1D2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_2nd_1	ECOD (1.6)
I	Cpn60_TCP1_1st	e3ko1I1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
I	Cpn60_TCP1_2nd	e3ko1I3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd	ECOD (1.6)
I	Cpn60_TCP1_2nd_1	e3ko1I2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_2nd_1	ECOD (1.6)
H	Cpn60_TCP1_1st	e3ko1H1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
H	Cpn60_TCP1_2nd	e3ko1H3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd	ECOD (1.6)
H	Cpn60_TCP1_2nd_1	e3ko1H2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_2nd_1	ECOD (1.6)
G	Cpn60_TCP1_1st	e3ko1G1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
G	Cpn60_TCP1_2nd	e3ko1G3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd	ECOD (1.6)
G	Cpn60_TCP1_2nd_1	e3ko1G2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_2nd_1	ECOD (1.6)
F	Cpn60_TCP1_1st	e3ko1F1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
F	Cpn60_TCP1_2nd	e3ko1F3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd	ECOD (1.6)
F	Cpn60_TCP1_2nd_1	e3ko1F2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_2nd_1	ECOD (1.6)
E	Cpn60_TCP1_1st	e3ko1E1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
E	Cpn60_TCP1_2nd	e3ko1E3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd	ECOD (1.6)
E	Cpn60_TCP1_2nd_1	e3ko1E2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_2nd_1	ECOD (1.6)
C	Cpn60_TCP1_1st	e3ko1C1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
C	Cpn60_TCP1_2nd	e3ko1C3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd	ECOD (1.6)
C	Cpn60_TCP1_2nd_1	e3ko1C2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_2nd_1	ECOD (1.6)
B	Cpn60_TCP1_1st	e3ko1B1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
B	Cpn60_TCP1_2nd	e3ko1B3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd	ECOD (1.6)
B	Cpn60_TCP1_2nd_1	e3ko1B2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_2nd_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
A	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
A	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
D	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
D	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
D	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
I	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
I	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
I	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
H	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
H	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
H	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
G	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
G	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
G	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
F	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
F	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
F	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
E	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
E	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
E	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
C	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
C	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
C	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
B	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
B	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
B	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I	PF00118	TCP-1/cpn60 chaperonin family (Cpn60_TCP1)	TCP-1/cpn60 chaperonin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I	Chaperonin	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding protein binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent protein folding chaperone protein folding chaperone identical protein binding	-	cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR027413	GroEL-like equatorial domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR054827	Thermosome subunit alpha	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR017998	Chaperone tailless complex polypeptide 1 (TCP-1)	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR027410	TCP-1-like chaperonin intermediate domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR012714	Thermosome, archaeal	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR053374	TCP-1 chaperonin-containing T-complex	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR002194	Chaperonin TCP-1, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR027409	GroEL-like apical domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR002423	Chaperonin Cpn60/GroEL/TCP-1 family	Family