3NMZ

Crystal structure of APC complexed with Asef

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	ARM repeat-like	8053357	3000116	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8053357	3000116	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	SH3-domain	8065211	3000153	SCOP2B (2022-06-29)
C [auth D]	SCOP2 Family	SH3-domain	8065210	4000369	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Superfamily	SH3-domain	8065211	3000153	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Arm	e3nmzB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Arm	ECOD (1.6)
A	Arm	e3nmzA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Arm	ECOD (1.6)
D [auth C]	SH3_1	e3nmzC1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
C [auth D]	SH3_1	e3nmzD1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
D [auth C]	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
C [auth D]	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat
A, B	PF18797	Adenomatous polyposis coli (APC) repeat (APC_rep)	Adenomatous polyposis coli (APC) repeat	-	Repeat
C [auth D], D [auth C]	PF00018	SH3 domain (SH3_1)	SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	APC variant protein	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding enzyme regulator activity molecular function regulator activity protein kinase regulator activity kinase regulator activity microtubule plus-end binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding gamma-catenin binding cytoskeletal protein binding microtubule binding protein binding binding tubulin binding enzyme regulator activity molecular function regulator activity protein kinase regulator activity kinase regulator activity microtubule plus-end binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding gamma-catenin binding kinase binding protein kinase binding beta-catenin binding protein-containing complex binding dynein complex binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process cellular developmental process cell differentiation cell fate specification cell fate commitment multicellular organism development multicellular organismal process anatomical structure development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process cellular developmental process cell differentiation cell fate specification cell fate commitment multicellular organism development multicellular organismal process anatomical structure development pattern specification process regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization cell projection organization positive regulation of biological process plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization pseudopodium assembly cellular component assembly positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process regulation of biological process plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly biological regulation regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly positive regulation of pseudopodium assembly regulation of pseudopodium assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly pseudopodium organization signaling negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death regulation of microtubule-based process regulation of microtubule-based movement microtubule-based movement microtubule-based process cell migration cell motility bicellular tight junction assembly tight junction organization apical junction assembly cell junction organization cell junction assembly tight junction assembly cell-cell junction assembly cell-cell junction organization nervous system development system development cell adhesion establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore regulation of cell cycle process establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation regulation of attachment of spindle microtubules to kinetochore cell cycle establishment of chromosome localization regulation of cell cycle chromosome segregation cell cycle process protein-containing complex organization protein-containing complex assembly mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cytokinesis cell division mitotic cell cycle regulation of cell cycle phase transition spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling mitotic sister chromatid separation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition regulation of mitotic cell cycle mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition catabolic process positive regulation of protein metabolic process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process protein metabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process regulation of catalytic activity negative regulation of catalytic activity regulation of cyclin-dependent protein kinase activity regulation of transferase activity negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process regulation of cyclin-dependent protein serine/threonine kinase activity phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation negative regulation of metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of protein serine/threonine kinase activity negative regulation of macromolecule metabolic process negative regulation of cyclin-dependent protein kinase activity negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process heart development mesenchyme morphogenesis endocardial cushion morphogenesis animal organ development heart morphogenesis mesenchyme development tissue development circulatory system development tissue morphogenesis anatomical structure morphogenesis endocardial cushion development animal organ morphogenesis heart valve development cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to insulin cellular response to insulin stimulus negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition negative regulation of G1/S transition of mitotic cell cycle negative regulation of cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion protein localization protein localization to microtubule cytoskeleton regulation of localization regulation of protein localization regulation of protein localization to centrosome protein localization to microtubule organizing center regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to cytoskeleton protein localization to organelle positive regulation of protein localization positive regulation of protein localization to centrosome protein localization to centrosome regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization negative regulation of microtubule depolymerization microtubule cytoskeleton organization protein-containing complex disassembly regulation of protein-containing complex disassembly microtubule polymerization or depolymerization regulation of microtubule depolymerization negative regulation of protein-containing complex disassembly negative regulation of supramolecular fiber organization cellular component disassembly negative regulation of microtubule polymerization or depolymerization regulation of protein depolymerization negative regulation of cytoskeleton organization negative regulation of protein depolymerization microtubule depolymerization regulation of supramolecular fiber organization supramolecular fiber organization protein depolymerization cytoskeleton organization regulation of microtubule cytoskeleton organization	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane plasma membrane membrane protein complex extrinsic component of membrane cell-cell junction adherens junction anchoring junction cell junction membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system perinuclear region of cytoplasm polymeric cytoskeletal fiber intracellular membraneless organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton ruffle leading edge membrane ruffle membrane plasma membrane region cell projection membrane centrosome microtubule organizing center catalytic complex beta-catenin destruction complex intracellular protein-containing complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Wnt signalosome chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome apical junction complex bicellular tight junction tight junction lateral plasma membrane
C [auth D], D [auth C]	Rho guanine nucleotide exchange factor 4	protein binding binding protein domain specific binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly filopodium assembly cellular response to stimulus regulation of biological process lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly filopodium assembly cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction	ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR009240	Adenomatous polyposis coli protein, 15 residue repeat	Repeat
A, B	IPR009232	EB-1 binding	Domain
A, B	IPR000225	Armadillo	Repeat
A, B	IPR009223	Adenomatous polyposis coli protein repeat	Repeat
A, B	IPR026818	Adenomatous polyposis coli (APC) family	Family
A, B	IPR036149	APC, N-terminal coiled-coil domain superfamily	Homologous Superfamily
A, B	IPR009224	SAMP	Repeat
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR041257	Adenomatous polyposis coli (APC) repeat	Repeat
A, B	IPR026831	Adenomatous polyposis coli protein	Homologous Superfamily
A, B	IPR009234	Adenomatous polyposis coli protein basic domain	Domain
A, B	IPR032038	Adenomatous polyposis coli, N-terminal dimerisation domain	Domain
C [auth D], D [auth C]	IPR001849	Pleckstrin homology domain	Domain
C [auth D], D [auth C]	IPR000219	Dbl homology (DH) domain	Domain
C [auth D], D [auth C]	IPR001452	SH3 domain	Domain
C [auth D], D [auth C]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
C [auth D], D [auth C]	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
C [auth D], D [auth C]	IPR011993	PH-like domain superfamily	Homologous Superfamily
C [auth D], D [auth C]	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site
C [auth D], D [auth C]	IPR055251	SOS1/NGEF-like, PH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P25054	medulloblastoma classic familial adenomatous polyposis glioblastoma colorectal cancer desmoid tumor hepatocellular carcinoma intellectual disability Adenomatous Polyps malignant colon neoplasm mismatch repair cancer syndrome 1 non-small cell lung carcinoma gastric cancer adenoma papillary adenoma follicular thyroid adenoma medulloblastoma classic familial adenomatous polyposis glioblastoma colorectal cancer desmoid tumor hepatocellular carcinoma intellectual disability Adenomatous Polyps malignant colon neoplasm mismatch repair cancer syndrome 1 non-small cell lung carcinoma gastric cancer adenoma papillary adenoma follicular thyroid adenoma Cenani-Lenz syndactyly syndrome giant cell glioblastoma granular cell carcinoma rectal neoplasm adult medulloblastoma microcystic adenoma liver cancer Gardner syndrome Lynch syndrome cancer prostate cancer colorectal adenoma tubular adenocarcinoma medullomyoblastoma with myogenic differentiation intestinal cancer familial adenomatous polyposis 1 benign colon neoplasm macrocytic anemia childhood medulloblastoma hepatoblastoma adenocarcinoma inflammatory bowel disease melanotic medulloblastoma adult acute respiratory distress syndrome liver neoplasm benign mesothelioma malignant glioma psoriasis colorectal adenocarcinoma stomach carcinoma in situ colorectal carcinoma medulloblastoma with extensive nodularity cribriform carcinoma of breast digestive system cancer large cell medulloblastoma attenuated familial adenomatous polyposis ovarian cancer lung adenocarcinoma benign neoplasm of pancreas Pick disease gastric carcinoma colon carcinoma rectal cancer schizophrenia hereditary diffuse gastric adenocarcinoma mammary neoplasms, animal hyperlipidemia adrenal cortex carcinoma desmoplastic/nodular medulloblastoma intestinal polyp digestive system disease atypical teratoid rhabdoid tumor pancreatic neoplasm lung benign neoplasm benign neoplasm of stomach pilocytic astrocytoma gastric neoplasm primitive neuroectodermal tumor genetic intestinal polyposis malignant ependymoma glioma colonic neoplasm rectal carcinoma cribriform carcinoma intestinal neoplasm mesothelioma diabetes mellitus astrocytic tumor exocrine pancreatic carcinoma autism oligodendroglioma familial hyperlipidemia
C [auth D], D [auth C]	Pharos: Q9NR80	atypical teratoid rhabdoid tumor ductal breast carcinoma in situ intellectual disability lung adenocarcinoma Malignant neoplasm of breast pilocytic astrocytoma subependymal giant cell astrocytoma breast cancer esophageal adenocarcinoma invasive ductal breast carcinoma malignant ependymoma medulloblastoma primitive neuroectodermal tumor breast carcinoma glioblastoma atypical teratoid rhabdoid tumor ductal breast carcinoma in situ intellectual disability lung adenocarcinoma Malignant neoplasm of breast pilocytic astrocytoma subependymal giant cell astrocytoma breast cancer esophageal adenocarcinoma invasive ductal breast carcinoma malignant ependymoma medulloblastoma primitive neuroectodermal tumor breast carcinoma glioblastoma large cell medulloblastoma malignant glioma ovarian cancer spina bifida