3T1R

MglB with tetrameric arrangement

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Roadblock/LC7 domain-like	8101643	3001810	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Roadblock/LC7 domain-like	8101643	3001810	SCOP2B (2022-06-29)
C	SCOP2 Family	Roadblock/LC7 domain-like	8101642	4001551	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Roadblock/LC7 domain-like	8101643	3001810	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Roadblock/LC7 domain-like	8101643	3001810	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Robl_LC7	e3t1rB1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Robl_LC7	ECOD (1.6)
A	Robl_LC7	e3t1rA1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Robl_LC7	ECOD (1.6)
C	Robl_LC7	e3t1rC1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Robl_LC7	ECOD (1.6)
D	Robl_LC7	e3t1rD1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Robl_LC7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)
A	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)
C	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)
D	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03259	Roadblock/LC7 domain (Robl_LC7)	Roadblock/LC7 domain	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is pro ...	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions [2]. This family also includes Swiss:Q9Y2Q5 Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus Swiss:Q50883, a protein involved in gliding motility [4]. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Gliding protein MglB	molecular adaptor activity GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	cellular response to acid chemical cellular response to stimulus cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to stimulus response to chemical cellular process response to amino acid positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process cellular response to acid chemical cellular response to stimulus cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to stimulus response to chemical cellular process response to amino acid positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR037587	Ragulator complex protein LAMTOR2-like	Family
A, B, C, D	IPR004942	Roadblock/LAMTOR2 domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.