Annotations: 3ZV0

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	SHQ1 C-terminal domain-like	8046678	4005235	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	SHQ1 C-terminal domain-like	8103589	3002783	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	SHQ1 C-terminal domain-like	8103589	3002783	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PUA	e3zv0D1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PUA domain	F: PUA	ECOD (1.6)
C	PUA	e3zv0C1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PUA domain	F: PUA	ECOD (1.6)
B	SHQ1	e3zv0B1	A: alpha arrays	X: SHQ1 C-terminal domain-like	H: SHQ1 C-terminal domain (From Topology)	T: SHQ1 C-terminal domain	F: SHQ1	ECOD (1.6)
A	SHQ1	e3zv0A1	A: alpha arrays	X: SHQ1 C-terminal domain-like	H: SHQ1 C-terminal domain (From Topology)	T: SHQ1 C-terminal domain	F: SHQ1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	2.30.130.10	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase	Chain: A, domain 4	CATH (4.3.0)
C	2.30.130.10	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase	Chain: A, domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, D	PF08068	DKCLD (NUC011) domain (DKCLD)	DKCLD (NUC011) domain	This is a TruB_N/PUA domain associated N-terminal domain of Dyskerin-like proteins [1].	Domain
C, D	PF01472	PUA domain (PUA)	PUA domain	The PUA domain named after Pseudouridine synthase and Archaeosine transglycosylase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases, a family of predicted ATPases that may be involved in RNA modificatio ...	The PUA domain named after Pseudouridine synthase and Archaeosine transglycosylase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases, a family of predicted ATPases that may be involved in RNA modification, a family of predicted archaeal and bacterial rRNA methylases. Additionally, the PUA domain was detected in a family of eukaryotic proteins that also contain a domain homologous to the translation initiation factor eIF1/SUI1; these proteins may comprise a novel type of translation factors. Unexpectedly, the PUA domain was detected also in bacterial and yeast glutamate kinases; this is compatible with the demonstrated role of these enzymes in the regulation of the expression of other genes [1]. It is predicted that the PUA domain is an RNA binding domain.	Domain
A, B	PF04925	SHQ1 protein, Shq1 domain (SHQ1)	SHQ1 protein, Shq1 domain	This domain is found at the C-terminal end of Protein SHQ1 homolog from humans and similar eukaryotic proteins. SHQ1 is a factor required for the biogenesis and assembly of H/ACA small nucleolar ribonucleoparticle (snoRNP), which are essential for ri ...	This domain is found at the C-terminal end of Protein SHQ1 homolog from humans and similar eukaryotic proteins. SHQ1 is a factor required for the biogenesis and assembly of H/ACA small nucleolar ribonucleoparticle (snoRNP), which are essential for ribosomal RNA and telomerase RNA processing and metabolism. This protein contains two domains: an N-terminal CS or HSP20-like domain (Pfam:PF21413) and a C-terminal region called the Shq1 domain (this entry). This domain adopts a mostly helical structure that consists of 17 alpha-helices and two short beta-strands [1,2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 4	isomerase activity snRNA pseudouridine synthase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid pseudouridine synthase activity catalytic activity intramolecular transferase activity DNA binding binding nucleic acid binding RNA binding mRNA binding	ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing rRNA modification nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process primary metabolic process gene expression ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing rRNA modification nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA modification biosynthetic process macromolecule modification metabolic process cellular process macromolecule metabolic process cell division pseudouridine synthesis rRNA pseudouridine synthesis snoRNA guided rRNA pseudouridine synthesis box H/ACA sno(s)RNA 3'-end processing sno(s)RNA processing sno(s)RNA 3'-end processing box H/ACA sno(s)RNA processing box H/ACA sno(s)RNA metabolic process sno(s)RNA metabolic process RNA 3'-end processing snRNA modification snRNA pseudouridine synthesis snRNA metabolic process snRNA processing mRNA modification mRNA metabolic process mRNA pseudouridine synthesis	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle chromosome, centromeric region intracellular membraneless organelle chromosome chromosomal region cytoplasm 90S preribosome preribosome protein-containing complex ribonucleoprotein complex intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle chromosome, centromeric region intracellular membraneless organelle chromosome chromosomal region cytoplasm 90S preribosome preribosome protein-containing complex ribonucleoprotein complex membrane-bounded organelle catalytic complex sno(s)RNA-containing ribonucleoprotein complex nucleus membrane-enclosed lumen nuclear protein-containing complex box H/ACA snoRNP complex intracellular membrane-bounded organelle nucleolus intracellular organelle lumen box H/ACA RNP complex organelle lumen nuclear lumen polymeric cytoskeletal fiber cytoskeleton supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
A, B	PROTEIN SHQ1	unfolded protein binding protein binding binding	ribonucleoprotein complex biogenesis box H/ACA snoRNP assembly protein-containing complex organization small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular process cellular component organization or biogenesis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D	IPR015947	PUA-like superfamily	Homologous Superfamily
C, D	IPR020103	Pseudouridine synthase, catalytic domain superfamily	Homologous Superfamily
C, D	IPR004521	Uncharacterised domain CHP00451	Domain
C, D	IPR002501	Pseudouridine synthase II, N-terminal	Domain
C, D	IPR036974	PUA domain superfamily	Homologous Superfamily
C, D	IPR004802	tRNA pseudouridine synthase B family	Family
C, D	IPR032819	tRNA pseudouridylate synthase B, C-terminal	Domain
C, D	IPR012960	Dyskerin-like	Domain
C, D	IPR002478	PUA domain	Domain
A, B	IPR007052	CS domain	Domain
A, B	IPR007009	Shq1, C-terminal domain	Domain
A, B	IPR048696	SHQ1-like, CS domain	Domain
A, B	IPR008978	HSP20-like chaperone	Homologous Superfamily
A, B	IPR039742	Protein Shq1	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.