3C9F | pdb_00003c9f

Crystal structure of 5'-nucleotidase from Candida albicans SC5314

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3c9fa1	Alpha and beta proteins (a+b)	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	(Candida albicans SC5314 ) [TaxId: 237561 ],	SCOPe (2.08)
A	d3c9fa2	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	(Candida albicans SC5314 ) [TaxId: 237561 ],	SCOPe (2.08)
A	d3c9fa3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Candida albicans SC5314 ) [TaxId: 237561 ],	SCOPe (2.08)
B	d3c9fb1	Alpha and beta proteins (a+b)	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	(Candida albicans SC5314 ) [TaxId: 237561 ],	SCOPe (2.08)
B	d3c9fb2	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	(Candida albicans SC5314 ) [TaxId: 237561 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	8027465	4001892	SCOP2 (2022-06-29)
A	SCOP2 Family	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	8027466	4002300	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	8039844	3000515	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Metallo-dependent phosphatases	8039845	3001067	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	8039844	3000515	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Metallo-dependent phosphatases	8039845	3001067	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Metallophos_2_1	e3c9fA2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
A	KOG4419	e3c9fA1	A: a+b complex topology	X: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	H: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	T: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	F: KOG4419	ECOD (1.6)
B	Metallophos_2_1	e3c9fB2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
B	KOG4419	e3c9fB1	A: a+b complex topology	X: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	H: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	T: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	F: KOG4419	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)
A	3.90.780.10	Alpha Beta	Alpha-Beta Complex	5'-nucleotidase	domain 2	CATH (4.3.0)
B	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)
B	3.90.780.10	Alpha Beta	Alpha-Beta Complex	5'-nucleotidase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
A, B	PF21953	NAD nucleotidase, C-terminal domain (NadN_nucleosid_C)	NAD nucleotidase, C-terminal domain	This is the C-terminal domain of a family of Zn2+-dependent 5'-nucleotidases. This domain has a four-layered structure with a five-stranded beta-sheet forming the core [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	5'-nucleotidase	hydrolase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	pyridine nucleotide catabolic process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process NAD metabolic process nucleobase-containing compound metabolic process NAD catabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process pyridine nucleotide catabolic process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process NAD metabolic process nucleobase-containing compound metabolic process NAD catabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleotide catabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process purine nucleotide catabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process purine-containing compound metabolic process organophosphate metabolic process metabolic process cellular process pyridine-containing compound catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
A, B	IPR041823	YHR202W-like, N-terminal metallophosphatase domain	Domain
A, B	IPR053828	Putative 5'-nucleotidase, C-terminal domain	Domain
A, B	IPR014485	Predicted phosphoesterase, C1039.02 type	Family
A, B	IPR036907	5'-Nucleotidase, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR006179	5'-Nucleotidase/apyrase	Family
A, B	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.