4H6Z | pdb_00004h6z

Tubulin acetyltransferase

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Acetyltransf_16	e4h6zB1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_16	ECOD (1.6)
A	Acetyltransf_16	e4h6zA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_16	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	6.20.370.120	Special	Other non-globular	Rhinovirus 14, subunit 4		CATH (4.3.0)
B	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
A	6.20.370.120	Special	Other non-globular	Rhinovirus 14, subunit 4		CATH (4.3.0)
A	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05301	GNAT acetyltransferase, Mec-17 (Acetyltransf_16)	GNAT acetyltransferase, Mec-17	Mec-17 is the protein product of one of the 18 genes required for the development and function of the touch receptor neuron for gentle touch. Mec-17 is specifically required for maintaining the differentiation of the touch receptor [1]. The family sh ...	Mec-17 is the protein product of one of the 18 genes required for the development and function of the touch receptor neuron for gentle touch. Mec-17 is specifically required for maintaining the differentiation of the touch receptor [1]. The family shares all the residue-motifs characteristic of Gcn5-related acetyl-transferases, though the exact unction is still unknown [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Alpha-tubulin N-acetyltransferase	acetyltransferase activity N-acetyltransferase activity acyltransferase activity L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity L-amino-acid N-acetyltransferase activity N-acyltransferase activity protein-lysine-acetyltransferase activity protein N-acetyltransferase activity catalytic activity, acting on a protein tubulin N-acetyltransferase activity protein N-acyltransferase activity	cellular component organization organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization peptidyl-lysine acetylation peptidyl-lysine modification alpha-tubulin acetylation primary metabolic process protein acylation protein acetylation internal peptidyl-lysine acetylation cellular component organization organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization peptidyl-lysine acetylation peptidyl-lysine modification alpha-tubulin acetylation primary metabolic process protein acylation protein acetylation internal peptidyl-lysine acetylation macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process protein modification process internal protein amino acid acetylation developmental process multicellular organismal process cellular developmental process cell development nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development system development regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation regulation of microtubule-based process regulation of organelle organization regulation of microtubule cytoskeleton organization	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction clathrin-coated pit membrane endomembrane system intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction clathrin-coated pit membrane endomembrane system intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton axon cell projection neuron projection plasma membrane bounded cell projection cytoplasm polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR007965	Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type	Domain
A, B	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A, B	IPR038746	Alpha-tubulin N-acetyltransferase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.