4HFZ

Crystal Structure of an MDM2/P53 Peptide Complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SWIB/MDM2 domain-like	8037458	3000287	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SWIB/MDM2 domain-like	8037458	3000287	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	p53 TAD	8093389	3002701	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	p53 TAD	8093389	3002701	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SWIB	e4hfzA1	A: alpha arrays	X: SWIB/MDM2 domain (From Topology)	H: SWIB/MDM2 domain (From Topology)	T: SWIB/MDM2 domain	F: SWIB	ECOD (1.6)
C	SWIB	e4hfzC1	A: alpha arrays	X: SWIB/MDM2 domain (From Topology)	H: SWIB/MDM2 domain (From Topology)	T: SWIB/MDM2 domain	F: SWIB	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.245.10	Mainly Alpha	Orthogonal Bundle	MDM2	SWIB/MDM2 domain	CATH (4.3.0)
C	1.10.245.10	Mainly Alpha	Orthogonal Bundle	MDM2	SWIB/MDM2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF02201	SWIB/MDM2 domain (SWIB)	SWIB/MDM2 domain	This family includes the SWIB domain and the MDM2 domain [1]. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. Thi ...	This family includes the SWIB domain and the MDM2 domain [1]. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2 [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	E3 ubiquitin-protein ligase Mdm2	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity SUMO transferase activity transferase activity catalytic activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding ligase activity protein domain specific binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity SUMO transferase activity transferase activity catalytic activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding ligase activity protein domain specific binding ubiquitin binding ubiquitin-like protein binding NEDD8 transferase activity NEDD8 ligase activity ubiquitin-like protein ligase activity ubiquitin-protein transferase activity signaling receptor binding peroxisome proliferator activated receptor binding ubiquitin protein ligase activity identical protein binding p53 binding RNA binding organic cyclic compound binding rRNA binding 5S rRNA binding nucleic acid binding ribonucleoprotein complex binding protein-containing complex binding receptor serine/threonine kinase binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding disordered domain specific binding	response to stimulus response to chemical response to xenobiotic stimulus response to oxygen-containing compound response to formaldehyde regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process response to stimulus response to chemical response to xenobiotic stimulus response to oxygen-containing compound response to formaldehyde regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process cellular response to nitrogen compound cellular response to stimulus response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone cellular response to hormone stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction negative regulation of apoptotic signaling pathway regulation of signal transduction by p53 class mediator negative regulation of cellular process signal transduction intrinsic apoptotic signaling pathway negative regulation of signal transduction by p53 class mediator regulation of signaling negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process signal transduction by p53 class mediator cell death negative regulation of signal transduction apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of response to stimulus regulation of cell communication intrinsic apoptotic signaling pathway by p53 class mediator apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator programmed cell death regulation of apoptotic signaling pathway response to antibiotic protein autoubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal peptidyl-lysine modification protein sumoylation peptidyl-amino acid modification positive regulation of proteasomal protein catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process positive regulation of cellular process proteasomal protein catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process fibroblast activation multicellular organismal process cell activation response to toxic substance response to metal ion response to iron ion response to immobilization stress response to stress response to water-immersion restraint stress response to estrogen cellular response to estrogen stimulus developmental process multicellular organism development anatomical structure development vasculature development blood vessel development system development circulatory system development RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process response to ether cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis heart development animal organ development ventricular septum development cardiac septum development cardiac chamber development cardiac ventricle development protein localization localization establishment of protein localization cellular localization cellular macromolecule localization macromolecule localization establishment of localization regulation of developmental process cellular developmental process regulation of cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation muscle structure development positive regulation of developmental process regulation of muscle cell differentiation positive regulation of cell differentiation cell differentiation supramolecular fiber organization amyloid fibril formation regulation of cellular response to stress DNA damage response, signal transduction by p53 class mediator cellular response to stress regulation of response to stress negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator DNA damage response signal transduction in response to DNA damage cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to UV-C response to UV-C cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV cardiac atrium development atrial septum development cellular response to growth factor stimulus response to growth factor regulation of protein maturation negative regulation of proteolysis negative regulation of protein maturation protein maturation negative regulation of protein metabolic process negative regulation of gene expression regulation of protein processing protein processing negative regulation of protein processing positive regulation of cell cycle mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle cell cycle regulation of cell cycle heart process system process regulation of heart contraction regulation of system process circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate protein destabilization regulation of protein stability positive regulation of macromolecule biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to hypoxia response to oxygen levels cellular response to alkaloid response to alkaloid response to nutrient levels response to vitamin B1 response to alcohol response to nutrient cellular response to organic cyclic compound response to vitamin cellular response to vitamin B1 cellular response to nutrient levels cellular response to alcohol cellular response to vitamin cellular response to nutrient response to organic cyclic compound regulation of cell cycle phase transition traversing start control point of mitotic cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition regulation of neuron projection development regulation of cellular component organization cell projection organization cell development neuron projection development neurogenesis neuron differentiation negative regulation of cell projection organization plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization cardiac chamber morphogenesis heart morphogenesis anatomical structure morphogenesis cardiac septum morphogenesis animal organ morphogenesis protein polyubiquitination response to lipid response to steroid hormone import into cell regulation of localization receptor internalization transport postsynaptic neurotransmitter receptor internalization regulation of receptor internalization vesicle-mediated transport vesicle-mediated transport in synapse establishment of localization in cell regulation of postsynaptic neurotransmitter receptor internalization regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis endocytosis receptor-mediated endocytosis response to actinomycin D cellular response to actinomycin D cellular response to antibiotic cellular response to ionizing radiation response to ionizing radiation cellular response to gamma radiation response to gamma radiation regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation regulation of vascular associated smooth muscle cell migration positive regulation of locomotion vascular associated smooth muscle cell migration regulation of cell motility regulation of smooth muscle cell migration positive regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of vascular associated smooth muscle cell migration cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species nitrogen compound transport regulation of protein localization nucleocytoplasmic transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of intracellular transport nuclear export regulation of protein export from nucleus regulation of intracellular transport regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport regulation of protein transport protein export from nucleus positive regulation of protein export from nucleus positive regulation of transport protein transport regulation of cellular localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport modulation of chemical synaptic transmission regulation of protein catabolic process at postsynapse, modulating synaptic transmission synaptic signaling postsynaptic modulation of chemical synaptic transmission trans-synaptic signaling cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling mesenchyme morphogenesis endocardial cushion morphogenesis mesenchyme development tissue development tissue morphogenesis endocardial cushion development blood vessel remodeling tissue remodeling negative regulation of cell cycle negative regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling DNA integrity checkpoint signaling DNA damage checkpoint signaling negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest response to cocaine protein localization to organelle protein localization to nucleus atrioventricular valve development heart valve development heart valve morphogenesis atrioventricular valve morphogenesis response to magnesium ion	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen cell periphery plasma membrane membrane protein-containing complex synapse cell junction glutamatergic synapse intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle organelle membrane endocytic vesicle nucleoplasm postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse transcription regulator complex transcription repressor complex
B, D	Cellular tumor antigen p53	TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone deacetylase binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone deacetylase binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity protein-folding chaperone binding chromatin binding promoter-specific chromatin binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein phosphatase binding phosphatase binding protein phosphatase 2A binding protease binding MDM2/MDM4 family protein binding molecular function activator activity sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding transcription regulatory region nucleic acid binding mRNA 3'-UTR binding RNA binding mRNA binding cation binding transition metal ion binding copper ion binding ion binding metal ion binding small molecule binding core promoter sequence-specific DNA binding 14-3-3 protein binding cis-regulatory region sequence-specific DNA binding protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding protein kinase binding identical protein binding p53 binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein dimerization activity molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity ATP-dependent DNA/DNA annealing activity DNA/DNA annealing activity annealing activity single-stranded DNA binding ATP-dependent activity zinc ion binding disordered domain specific binding protein domain specific binding	catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion biological regulation regulation of mitophagy regulation of catabolic process negative regulation of mitophagy negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy cellular process metabolic process regulation of metabolic process autophagy of mitochondrion regulation of protein stability regulation of biological quality protein stabilization positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process epigenetic regulation of gene expression primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process macromolecule metabolic process membrane organization transport apoptotic mitochondrial changes cell death establishment of localization mitochondrial membrane organization localization organelle organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process regulation of mitochondrial membrane permeability programmed cell death mitochondrion organization mitochondrial transport protein localization cellular localization cellular macromolecule localization macromolecule localization cellular response to stimulus response to stimulus signaling signal transduction by p53 class mediator intracellular signal transduction cell communication apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator signal transduction intrinsic apoptotic signaling pathway multicellular organismal process cellular developmental process regulation of developmental process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis negative regulation of glial cell proliferation regulation of cell development regulation of nervous system development neurogenesis multicellular organism development negative regulation of neurogenesis regulation of glial cell proliferation gliogenesis cell differentiation anatomical structure development regulation of multicellular organismal process negative regulation of nervous system development negative regulation of cell differentiation system development developmental process regulation of multicellular organismal development negative regulation of cell population proliferation cell population proliferation negative regulation of developmental process nervous system development negative regulation of gliogenesis negative regulation of cell development regulation of cell population proliferation glial cell proliferation negative regulation of multicellular organismal process response to stress response to ischemia response to chemical response to antibiotic response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus replicative senescence transcription preinitiation complex assembly regulation of primary metabolic process cellular component biogenesis regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process RNA polymerase II preinitiation complex assembly regulation of DNA-templated transcription regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization positive regulation of DNA-templated transcription protein-DNA complex organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly protein-containing complex assembly regulation of RNA biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly regulation of cellular component biogenesis positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II head development animal organ development brain development cerebellum development central nervous system development metencephalon development hindbrain development tissue remodeling regulation of tissue remodeling positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription regulation of miRNA metabolic process miRNA metabolic process regulation of miRNA transcription regulation of stem cell proliferation negative regulation of stem cell proliferation stem cell proliferation biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cytokine-mediated signaling pathway cellular response to type II interferon response to biotic stimulus interferon-mediated signaling pathway innate immune response cellular response to cytokine stimulus response to external biotic stimulus cell surface receptor signaling pathway immune response response to other organism defense response type II interferon-mediated signaling pathway defense response to symbiont response to external stimulus response to peptide immune system process defense response to other organism hemopoiesis cell activation mononuclear cell differentiation T cell lineage commitment lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation T cell differentiation cell fate commitment leukocyte differentiation reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process fibroblast proliferation DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response DNA repair cellular response to chemical stimulus cellular response to xenobiotic stimulus response to xenobiotic stimulus cellular response to biotic stimulus ER overload response ER-nucleus signaling pathway response to endoplasmic reticulum stress negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process multicellular organism growth developmental growth growth regulation of amide metabolic process negative regulation of small molecule metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of phosphate metabolic process regulation of nucleotide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process negative regulation of pentose-phosphate shunt regulation of phosphorus metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process glucose 6-phosphate metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process regulation of NADP metabolic process amide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process NADP metabolic process NADPH regeneration organophosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of DNA replication DNA replication negative regulation of DNA metabolic process regulation of DNA metabolic process regulation of DNA replication response to osmotic stress response to salt stress cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator DNA damage response, signal transduction by p53 class mediator DNA damage response, signal transduction resulting in transcription signal transduction in response to DNA damage somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process fibroblast apoptotic process regulation of fibroblast apoptotic process negative regulation of ATP-dependent activity regulation of helicase activity regulation of molecular function regulation of ATP-dependent activity regulation of catalytic activity negative regulation of molecular function negative regulation of helicase activity negative regulation of catalytic activity regulation of signal transduction regulation of intrinsic apoptotic signaling pathway regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator regulation of signaling regulation of response to stimulus regulation of cell communication regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to decreased oxygen levels intrinsic apoptotic signaling pathway in response to hypoxia response to hypoxia response to oxygen levels negative regulation of proteolysis regulation of protein metabolic process regulation of proteolysis proteolysis protein metabolic process negative regulation of protein metabolic process positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process leukocyte apoptotic process positive regulation of thymocyte apoptotic process lymphocyte apoptotic process thymocyte apoptotic process regulation of T cell apoptotic process positive regulation of leukocyte apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process positive regulation of lymphocyte apoptotic process positive regulation of T cell apoptotic process regulation of thymocyte apoptotic process T cell apoptotic process positive regulation of reactive oxygen species metabolic process small GTPase-mediated signal transduction Ras protein signal transduction intracellular signaling cassette immune system development hematopoietic or lymphoid organ development bone marrow development skeletal system development bone development response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to UV-C response to UV-C cellular response to light stimulus cellular response to abiotic stimulus cellular response to UV neuron apoptotic process regulation of cellular senescence cellular senescence positive regulation of cellular senescence response to gamma radiation necroptotic process programmed necrotic cell death cell activation involved in immune response leukocyte proliferation immune effector process T cell proliferation involved in immune response T cell activation involved in immune response mononuclear cell proliferation lymphocyte proliferation leukocyte activation involved in immune response lymphocyte activation involved in immune response T cell proliferation oligodendrocyte apoptotic process glial cell apoptotic process regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation peptidyl-tyrosine phosphorylation neuroblast proliferation generation of neurons neural precursor cell proliferation cell cycle G2/M phase transition regulation of cell cycle phase transition regulation of cell cycle process regulation of cell cycle G2/M phase transition cell cycle phase transition cell cycle regulation of cell cycle cell cycle process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability B cell activation B cell lineage commitment B cell differentiation positive regulation of organelle organization regulation of release of cytochrome c from mitochondria positive regulation of release of cytochrome c from mitochondria regulation of organelle organization release of cytochrome c from mitochondria regulation of mitochondrion organization protein complex oligomerization protein tetramerization viral process cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation negative regulation of neural precursor cell proliferation regulation of neuroblast proliferation negative regulation of neuroblast proliferation regulation of neural precursor cell proliferation positive regulation of neuron apoptotic process regulation of neuron apoptotic process cellular response to ionizing radiation regulation of growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport intracellular transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport DNA damage checkpoint signaling negative regulation of cell cycle regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle G1/S phase transition DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis execution phase of apoptosis in utero embryonic development T cell differentiation in thymus heart development cardiac chamber morphogenesis heart morphogenesis circulatory system development cardiac septum development cardiac septum morphogenesis cardiac chamber development animal organ morphogenesis embryonic organ development mRNA transcription mRNA metabolic process negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway rhythmic process entrainment of circadian clock circadian rhythm regulation of circadian rhythm photoperiodism entrainment of circadian clock by photoperiod behavior circadian behavior rhythmic behavior rRNA transcription rRNA metabolic process regulation of fibroblast proliferation negative regulation of fibroblast proliferation positive regulation of cell communication positive regulation of signal transduction positive regulation of apoptotic signaling pathway positive regulation of response to stimulus positive regulation of intracellular signal transduction positive regulation of intrinsic apoptotic signaling pathway positive regulation of signaling cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor regulation of programmed necrotic cell death positive regulation of programmed necrotic cell death post-transcriptional regulation of gene expression RNA processing regulation of miRNA processing miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression negative regulation of miRNA-mediated gene silencing post-transcriptional gene silencing miRNA processing negative regulation of post-transcriptional gene silencing regulation of miRNA-mediated gene silencing negative regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of miRNA processing negative regulation of gene silencing by regulatory ncRNA regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of post-transcriptional gene silencing negative regulation of G1 to G0 transition regulation of G1 to G0 transition G1 to G0 transition cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound response to actinomycin D cellular response to oxygen-containing compound cellular response to actinomycin D cellular response to antibiotic cellular response to oxidative stress cellular response to chemical stress oxidative stress-induced premature senescence response to oxidative stress stress-induced premature senescence cellular response to gamma radiation chromosome organization embryonic morphogenesis gastrulation regulation of cellular response to stress regulation of response to stress regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of telomere maintenance telomere organization negative regulation of telomere maintenance via telomerase regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening negative regulation of chromosome organization negative regulation of cellular component organization regulation of chromosome organization regulation of telomere maintenance via telomere lengthening telomere maintenance DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening telomere maintenance via telomerase regulation of telomere maintenance via telomerase negative regulation of organelle organization glucose catabolic process to lactate via pyruvate oxoacid metabolic process organic acid metabolic process lactate metabolic process glycolytic fermentation negative regulation of carbohydrate metabolic process hexose catabolic process hexose metabolic process glucose catabolic process monocarboxylic acid metabolic process glucose catabolic process to lactate monosaccharide catabolic process small molecule catabolic process monosaccharide metabolic process energy derivation by oxidation of organic compounds negative regulation of fermentation organic hydroxy compound metabolic process fermentation regulation of glucose catabolic process to lactate via pyruvate regulation of glucose metabolic process carboxylic acid metabolic process negative regulation of glucose catabolic process to lactate via pyruvate regulation of fermentation glucose metabolic process determination of adult lifespan stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress mitochondrial genome maintenance mitochondrial DNA metabolic process mitochondrial DNA repair intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage double-strand break repair	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen germ cell nucleus protein-containing complex replication fork chromosome site of double-strand break site of DNA damage mitochondrion mitochondrial matrix transcription regulator complex chromatin nuclear periphery nuclear matrix centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton nucleoplasm transcription repressor complex endoplasmic reticulum endomembrane system nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR003121	SWIB/MDM2 domain	Domain
A, C	IPR016495	p53 negative regulator Mdm2/Mdm4	Family
A, C	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, C	IPR001876	Zinc finger, RanBP2-type	Domain
A, C	IPR036443	Zinc finger, RanBP2-type superfamily	Homologous Superfamily
A, C	IPR036885	SWIB/MDM2 domain superfamily	Homologous Superfamily
A, C	IPR044080	MDM2, modified RING finger, HC subclass	Domain
A, C	IPR001841	Zinc finger, RING-type	Domain
A, C	IPR028340	E3 ubiquitin-protein ligase Mdm2	Family
B, D	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B, D	IPR002117	p53 tumour suppressor family	Family
B, D	IPR013872	p53 transactivation domain	Domain
B, D	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
B, D	IPR011615	p53, DNA-binding domain	Domain
B, D	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B, D	IPR010991	p53, tetramerisation domain	Domain
B, D	IPR040926	Cellular tumor antigen p53, transactivation domain 2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q00987	melanoma cancer Li-Fraumeni syndrome prostate cancer HIV infectious disease non-small cell lung carcinoma breast carcinoma well-differentiated liposarcoma male infertility gastric carcinoma precancerous condition hematologic disease SAPHO syndrome Subfertility, Male lipoma melanoma cancer Li-Fraumeni syndrome prostate cancer HIV infectious disease non-small cell lung carcinoma breast carcinoma well-differentiated liposarcoma male infertility gastric carcinoma precancerous condition hematologic disease SAPHO syndrome Subfertility, Male lipoma acute lymphoblastic leukemia lymphatic system disease amyotrophic lateral sclerosis breast cancer cutaneous melanoma exocrine pancreatic carcinoma peripheral nervous system disease glioblastoma hepatocellular carcinoma sarcoma juvenile dermatomyositis urinary bladder cancer lung cancer acute myeloid leukemia atypical lipomatous tumor malignant colon neoplasm malignant pancreatic neoplasm connective tissue disease myopathy Dedifferentiated liposarcoma osteosarcoma gastric cancer peripheral neuropathy primitive neuroectodermal tumor glioma psoriasis subependymal giant cell astrocytoma lung disease acute promyelocytic leukemia atypical teratoid rhabdoid tumor malignant mesothelioma breast disease colorectal adenocarcinoma Crohn disease Emery-Dreifuss muscular dystrophy ovarian cancer
B, D	Pharos: P04637	Li-Fraumeni syndrome melanoma cholangiocarcinoma choroid plexus papilloma angiosarcoma B-cell chronic lymphocytic leukemia adrenal cortex carcinoma esophageal cancer adrenocortical carcinoma, hereditary malignant glioma renal cell carcinoma urinary bladder cancer skin basal cell carcinoma squamous cell carcinoma psoriasis Li-Fraumeni syndrome melanoma cholangiocarcinoma choroid plexus papilloma angiosarcoma B-cell chronic lymphocytic leukemia adrenal cortex carcinoma esophageal cancer adrenocortical carcinoma, hereditary malignant glioma renal cell carcinoma urinary bladder cancer skin basal cell carcinoma squamous cell carcinoma psoriasis osteosarcoma head and neck squamous cell carcinoma esophageal squamous cell carcinoma small cell lung carcinoma amyotrophic lateral sclerosis nasopharyngeal carcinoma hypertensive disorder T-cell non-Hodgkin lymphoma Balkan nephropathy adenoma choroid plexus carcinoma hypertrophic cardiomyopathy colorectal cancer kidney Wilms tumor glioblastoma skin neoplasm gallbladder cancer thymoma cancer malignant mesothelioma transitional cell carcinoma non-small cell lung carcinoma cutaneous melanoma esophageal adenocarcinoma primary cutaneous T-cell non-Hodgkin lymphoma breast adenocarcinoma male infertility Neoplasm Metastasis thyroid gland carcinoma keratosis salivary gland adenoid cystic carcinoma astrocytic tumor giant cell glioblastoma carotid artery disease sarcomatoid carcinoma central nervous system cancer ovarian cancer Li-Fraumeni syndrome 1 Sezary syndrome liver cancer papillary renal cell carcinoma small cell carcinoma essential thrombocythemia spindle cell sarcoma microcystic adenoma hepatocellular carcinoma brain ischemia clear cell adenocarcinoma familial pancreatic carcinoma breast cancer collecting duct carcinoma follicular thyroid adenoma thymic carcinoma gastric cancer thyroid adenoma carcinoma tubular adenocarcinoma demyelinating disease sarcomatoid renal cell carcinoma gliosarcoma penile neoplasm adrenal gland cancer polyploidy lung cancer exocrine pancreatic carcinoma mixed glioma myelodysplastic syndrome prostate cancer female infertility breast carcinoma malignant colon neoplasm intrahepatic cholangiocarcinoma vulvar lichen sclerosus sarcoma adenocarcinoma schizophrenia granular cell carcinoma adenoid cystic carcinoma skin cancer papillary adenoma chromophobe renal cell carcinoma lung carcinoma brain glioma mouth disease chronic obstructive pulmonary disease eye disease prostate disease breast disease colorectal adenocarcinoma pulmonary emphysema malignant ependymoma gallbladder neoplasm thymus neoplasm uterine corpus leiomyoma renal carcinoma neuroblastoma acute kidney failure cribriform carcinoma triple-negative breast carcinoma oligodendroglioma acute megakaryoblastic leukemia glioma susceptibility 1 undifferentiated carcinoma granulomatous slack skin disease urinary bladder neoplasm ovarian neoplasm skin disease benign neoplasm of pancreas head and neck carcinoma childhood acute lymphoblastic leukemia bile duct cancer medulloblastoma penile cancer polycystic ovary syndrome lung benign neoplasm bone osteosarcoma lung disease hereditary breast ovarian cancer syndrome primitive neuroectodermal tumor lymphatic system disease subependymal giant cell astrocytoma nasopharyngeal carcinoma, susceptibility to, 1 Burkitt lymphoma neoplasm of esophagus intestinal disease ischemic disease uterine disease congenital anemia neurodegenerative disease cribriform carcinoma of breast SAPHO syndrome atypical teratoid rhabdoid tumor oral cavity neoplasm acute myeloid leukemia ovarian carcinoma Li-Fraumeni syndrome 2 basal cell carcinoma, susceptibility to, 7 malignant pancreatic neoplasm Hantavirus hemorrhagic fever with renal syndrome, Puumala virus type urogenital neoplasm cervical cancer pancreatic neoplasm epithelioid sarcoma benign urinary system neoplasm head and neck neoplasm uterine cervix carcinoma in situ papilloma liver neoplasm esophageal disease bone disease hematopoietic and lymphoid system neoplasm adult hepatocellular carcinoma brain disease chromosome 17p deletion stomach disease hereditary diffuse gastric adenocarcinoma clear cell renal carcinoma nasopharyngeal neoplasm IgA glomerulonephritis colonic neoplasm anemia colorectal carcinoma pustulosis palmaris et plantaris gastric neoplasm thyroid cancer rheumatoid arthritis kidney disease large cell medulloblastoma autoimmune disease glioma urinary bladder disease ovarian disease endometriosis benign colon neoplasm head and neck cancer cervical carcinoma adrenal carcinoma liver disease skin pigmented basal cell carcinoma choroid plexus cancer pilocytic astrocytoma bone marrow disease metabolic syndrome X hepatoblastoma

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