Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Bd4i02b2 All alpha proteins DNA/RNA-binding 3-helical bundle 'Winged helix' DNA-binding domain automated matches automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Bd4i02b1 All beta proteins Double-stranded beta-helix cAMP-binding domain-like cAMP-binding domain automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ed4i02e2 All alpha proteins DNA/RNA-binding 3-helical bundle 'Winged helix' DNA-binding domain automated matches automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ed4i02e1 All beta proteins Double-stranded beta-helix cAMP-binding domain-like cAMP-binding domain automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Fd4i02f2 All alpha proteins DNA/RNA-binding 3-helical bundle 'Winged helix' DNA-binding domain automated matches automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Fd4i02f1 All beta proteins Double-stranded beta-helix cAMP-binding domain-like cAMP-binding domain automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ad4i02a2 All alpha proteins DNA/RNA-binding 3-helical bundle 'Winged helix' DNA-binding domain automated matches automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ad4i02a1 All beta proteins Double-stranded beta-helix cAMP-binding domain-like cAMP-binding domain automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Cd4i02c2 All alpha proteins DNA/RNA-binding 3-helical bundle 'Winged helix' DNA-binding domain automated matches automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Cd4i02c1 All beta proteins Double-stranded beta-helix cAMP-binding domain-like cAMP-binding domain automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Dd4i02d2 All alpha proteins DNA/RNA-binding 3-helical bundle 'Winged helix' DNA-binding domain automated matches automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Dd4i02d1 All beta proteins Double-stranded beta-helix cAMP-binding domain-like cAMP-binding domain automated matches (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyWinged helix DNA-binding domain 8002723 3000034 SCOP2B (2022-06-29)
BSCOP2B SuperfamilycAMP-binding domain-like 8002726 3000084 SCOP2B (2022-06-29)
ESCOP2B SuperfamilycAMP-binding domain-like 8002726 3000084 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyWinged helix DNA-binding domain 8002723 3000034 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyWinged helix DNA-binding domain 8002723 3000034 SCOP2B (2022-06-29)
FSCOP2B SuperfamilycAMP-binding domain-like 8002726 3000084 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyWinged helix DNA-binding domain 8002723 3000034 SCOP2B (2022-06-29)
ASCOP2B SuperfamilycAMP-binding domain-like 8002726 3000084 SCOP2B (2022-06-29)
CSCOP2B SuperfamilycAMP-binding domain-like 8002726 3000084 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyWinged helix DNA-binding domain 8002723 3000034 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyWinged helix DNA-binding domain 8002723 3000034 SCOP2B (2022-06-29)
DSCOP2B SuperfamilycAMP-binding domain-like 8002726 3000084 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BcNMP_bindinge4i02B1 A: beta sandwichesX: jelly-rollH: Double-stranded beta-helix (From Topology)T: Double-stranded beta-helixF: cNMP_bindingECOD (1.6)
BCrpe4i02B2 A: alpha arraysX: HTHH: HTHT: wingedF: CrpECOD (1.6)
EcNMP_bindinge4i02E1 A: beta sandwichesX: jelly-rollH: Double-stranded beta-helix (From Topology)T: Double-stranded beta-helixF: cNMP_bindingECOD (1.6)
ECrpe4i02E2 A: alpha arraysX: HTHH: HTHT: wingedF: CrpECOD (1.6)
FcNMP_bindinge4i02F1 A: beta sandwichesX: jelly-rollH: Double-stranded beta-helix (From Topology)T: Double-stranded beta-helixF: cNMP_bindingECOD (1.6)
FCrpe4i02F2 A: alpha arraysX: HTHH: HTHT: wingedF: CrpECOD (1.6)
AcNMP_bindinge4i02A1 A: beta sandwichesX: jelly-rollH: Double-stranded beta-helix (From Topology)T: Double-stranded beta-helixF: cNMP_bindingECOD (1.6)
ACrpe4i02A2 A: alpha arraysX: HTHH: HTHT: wingedF: CrpECOD (1.6)
CcNMP_bindinge4i02C1 A: beta sandwichesX: jelly-rollH: Double-stranded beta-helix (From Topology)T: Double-stranded beta-helixF: cNMP_bindingECOD (1.6)
CCrpe4i02C2 A: alpha arraysX: HTHH: HTHT: wingedF: CrpECOD (1.6)
DcNMP_bindinge4i02D1 A: beta sandwichesX: jelly-rollH: Double-stranded beta-helix (From Topology)T: Double-stranded beta-helixF: cNMP_bindingECOD (1.6)
DCrpe4i02D2 A: alpha arraysX: HTHH: HTHT: wingedF: CrpECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B, C, D, E
ARO:3000518CRPCRP is a global regulator that represses MdtEF multidrug efflux pump expression.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B, C, D, E
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpmacrolide antibiotic, fluoroquinolone antibiotic, penamantibiotic effluxCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF13545Crp-like helix-turn-helix domain (HTH_Crp_2)Crp-like helix-turn-helix domainThis family represents a crp-like helix-turn-helix domain that is likely to bind DNA.Domain
A, B, C, D, E
PF00027Cyclic nucleotide-binding domain (cNMP_binding)Cyclic nucleotide-binding domainThis domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Catabolite gene activator

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR050397Global Transcriptional Regulators in Environmental ResponseFamily
A, B, C, D, E
IPR000595Cyclic nucleotide-binding domainDomain
A, B, C, D, E
IPR036388Winged helix-like DNA-binding domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR036390Winged helix DNA-binding domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR012318Crp-type HTH domainDomain
A, B, C, D, E
IPR014710RmlC-like jelly roll foldHomologous Superfamily
A, B, C, D, E
IPR018488Cyclic nucleotide-binding, conserved siteConserved Site
A, B, C, D, E
IPR018335Transcription regulator HTH, Crp-type, conserved siteConserved Site
A, B, C, D, E
IPR018490Cyclic nucleotide-binding domain superfamilyHomologous Superfamily