4I2Z | pdb_00004i2z

Crystal structure of the myosin chaperone UNC-45 from C.elegans in complex with a Hsp90 peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	UCS-like	8046878	4005344	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ARM repeat-like	8103708	3000116	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNC45-central	e4i2zA3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: UNC45-central	ECOD (1.6)
A	TPR_11_5	e4i2zA4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF11701	Myosin-binding striated muscle assembly central (UNC45-central)	Myosin-binding striated muscle assembly central	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Heat shock protein 90	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding nuclear glucocorticoid receptor binding DNA-binding transcription factor binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding nuclear glucocorticoid receptor binding DNA-binding transcription factor binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity protein phosphatase binding phosphatase binding protein phosphatase 5 binding enzyme binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding	developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development regulation of protein stability biological regulation regulation of biological quality protein stabilization chemotaxis regulation of biological process response to stimulus developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development regulation of protein stability biological regulation regulation of biological quality protein stabilization chemotaxis regulation of biological process response to stimulus regulation of response to external stimulus response to external stimulus regulation of chemotaxis taxis regulation of response to stimulus response to chemical regulation of locomotion locomotion cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell macromolecule localization cellular process intracellular protein localization nuclear export intracellular protein transport protein folding biosynthetic process metabolic process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation cellular response to stimulus cellular response to heat cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus dauer larval development determination of adult lifespan biological process involved in interspecies interaction between organisms response to other organism defense response defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium response to bacterium response to external biotic stimulus	phosphatase complex protein-containing complex catalytic complex protein serine/threonine phosphatase complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane microdomain membrane raft HSP90-CDC37 chaperone complex phosphatase complex protein-containing complex catalytic complex protein serine/threonine phosphatase complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane microdomain membrane raft HSP90-CDC37 chaperone complex protein folding chaperone complex intracellular protein-containing complex perinuclear region of cytoplasm
A	Protein UNC-45	Hsp90 protein binding protein binding binding heat shock protein binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding protein folding chaperone identical protein binding	locomotion protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation behavior egg-laying behavior multicellular organismal process locomotion protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation behavior egg-laying behavior multicellular organismal process reproductive process multicellular organismal reproductive process reproductive behavior developmental process muscle structure development animal organ development anatomical structure development muscle organ development multicellular organism development embryo development ending in birth or egg hatching embryo development cellular developmental process cellular component assembly involved in morphogenesis cell development membraneless organelle assembly muscle cell differentiation cellular component organization cellular component biogenesis striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation sarcomere organization actin filament-based process cellular component organization or biogenesis actomyosin structure organization actin cytoskeleton organization organelle assembly anatomical structure morphogenesis myofibril assembly organelle organization anatomical structure formation involved in morphogenesis striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm perinuclear region of cytoplasm plasma membrane membrane cell division site cleavage furrow plasma membrane region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
B	IPR037196	HSP90, C-terminal domain	Homologous Superfamily
B	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
B	IPR001404	Heat shock protein Hsp90 family	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR024660	UNC-45/Cro1/She4, central domain	Domain
A	IPR019734	Tetratricopeptide repeat	Repeat

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.