4PSR

Crystal Structure of alpha-L-fucosidase from Fusarium graminearum in the open form in complex with L-fucose

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	FCO1 C-terminal domain like	8046105	4004879	SCOP2 (2022-06-29)
B	SCOP2 Family	Putative alpha-L-fucosidase, catalytic domain	8092879	4000966	SCOP2 (2022-06-29)
B	SCOP2 Family	Putative alpha-L-fucosidase C-terminal domain	8092881	4000939	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	gamma-Crystallin-like	8092878	3001138	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	(Trans)glycosidases	8092880	3000313	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Glycosyl hydrolase domain-like	8092882	3001528	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	gamma-Crystallin-like	8092878	3001138	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Glycosyl hydrolase domain-like	8092882	3001528	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	(Trans)glycosidases	8092880	3000313	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Fucosidase_C	e4psrB2	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: Fucosidase_C	ECOD (1.6)
B	Crystall_3	e4psrB3	A: beta sandwiches	X: gamma-Crystallin-like (From Topology)	H: gamma-Crystallin-like (From Topology)	T: gamma-Crystallin-like	F: Crystall_3	ECOD (1.6)
B	Alpha_L_fucos	e4psrB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Alpha_L_fucos	ECOD (1.6)
A	Fucosidase_C	e4psrA3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: Fucosidase_C	ECOD (1.6)
A	Crystall_3	e4psrA2	A: beta sandwiches	X: gamma-Crystallin-like (From Topology)	H: gamma-Crystallin-like (From Topology)	T: gamma-Crystallin-like	F: Crystall_3	ECOD (1.6)
A	Alpha_L_fucos	e4psrA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Alpha_L_fucos	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
B	2.60.40.1180	Mainly Beta	Sandwich	Immunoglobulin-like	Golgi alpha-mannosidase II	CATH (4.3.0)
B	2.60.20.10	Mainly Beta	Sandwich	Gamma-B Crystallin	domain 1	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	2.60.40.1180	Mainly Beta	Sandwich	Immunoglobulin-like	Golgi alpha-mannosidase II	CATH (4.3.0)
A	2.60.20.10	Mainly Beta	Sandwich	Gamma-B Crystallin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16757	Alpha-L-fucosidase C-terminal domain (Fucosidase_C)	Alpha-L-fucosidase C-terminal domain	The C-terminal domain of PDB:1hl8 is constructed of eight anti-parallel-strands packed into two-sheets of five and three strands, respectively, forming a two-layer-sandwich containing a Greek key motif [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Alpha-fucosidase GH29	fucosidase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds alpha-L-fucosidase activity hydrolase activity catalytic activity	monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process metabolic process cellular process primary metabolic process fucose metabolic process glycoside catabolic process carbohydrate derivative catabolic process glycosyl compound metabolic process catabolic process glycoside metabolic process carbohydrate derivative metabolic process monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process metabolic process cellular process primary metabolic process fucose metabolic process glycoside catabolic process carbohydrate derivative catabolic process glycosyl compound metabolic process catabolic process glycoside metabolic process carbohydrate derivative metabolic process glycosyl compound catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR031919	Alpha-L-fucosidase, C-terminal	Domain
A, B	IPR011024	Gamma-crystallin-like	Homologous Superfamily
A, B	IPR016286	Alpha-L-fucosidase, metazoa-type	Family
A, B	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily
A, B	IPR000933	Glycoside hydrolase, family 29	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.