4Q5I | pdb_00004q5i

Crystal structure of a T151A mutant of the E. coli FeoB G-domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
F	d4q5if_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Ferrous iron transport protein FeoB	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
E	d4q5ie_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Ferrous iron transport protein FeoB	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d4q5id_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Ferrous iron transport protein FeoB	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d4q5ic_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Ferrous iron transport protein FeoB	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d4q5ib_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Ferrous iron transport protein FeoB	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
A	d4q5ia_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Ferrous iron transport protein FeoB	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F	SCOP2B Superfamily	Ras-like P-loop GTPases	8019390	3002022	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ras-like P-loop GTPases	8019390	3002022	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ras-like P-loop GTPases	8019390	3002022	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ras-like P-loop GTPases	8019390	3002022	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ras-like P-loop GTPases	8019390	3002022	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8019390	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F	feoB	e4q5iF2	A: alpha complex topology	X: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	H: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	T: Cytosolic helical domain in ferrous iron transport protein B	F: feoB	ECOD (1.6)
F	MnmE_helical_2nd	e4q5iF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
E	feoB	e4q5iE1	A: alpha complex topology	X: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	H: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	T: Cytosolic helical domain in ferrous iron transport protein B	F: feoB	ECOD (1.6)
E	MnmE_helical_2nd	e4q5iE2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
D	feoB	e4q5iD1	A: alpha complex topology	X: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	H: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	T: Cytosolic helical domain in ferrous iron transport protein B	F: feoB	ECOD (1.6)
D	MnmE_helical_2nd	e4q5iD2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
C	feoB	e4q5iC2	A: alpha complex topology	X: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	H: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	T: Cytosolic helical domain in ferrous iron transport protein B	F: feoB	ECOD (1.6)
C	MnmE_helical_2nd	e4q5iC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
B	feoB	e4q5iB2	A: alpha complex topology	X: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	H: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	T: Cytosolic helical domain in ferrous iron transport protein B	F: feoB	ECOD (1.6)
B	MnmE_helical_2nd	e4q5iB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
A	feoB	e4q5iA1	A: alpha complex topology	X: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	H: Cytosolic helical domain in ferrous iron transport protein B (From Topology)	T: Cytosolic helical domain in ferrous iron transport protein B	F: feoB	ECOD (1.6)
A	MnmE_helical_2nd	e4q5iA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
F	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
F	1.10.287.1770	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
E	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
E	1.10.287.1770	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
D	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D	1.10.287.1770	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	1.10.287.1770	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	1.10.287.1770	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	1.10.287.1770	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF02421	Ferrous iron transport protein B (FeoB_N)	Ferrous iron transport protein B	Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino a ...	Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent [1].	Domain
A, B, C, D, E A, B, C, D, E, F	PF17910	FeoB cytosolic helical domain (FeoB_Cyto)	FeoB cytosolic helical domain	FeoB is a G-protein coupled membrane protein essential for Fe(II) uptake in prokaryotes. In the structures, a canonical G-protein domain (G domain) is followed by a helical bundle domain (S-domain) which is represented by this entry.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Ferrous iron transport protein B	monoatomic cation transmembrane transporter activity iron ion transmembrane transporter activity monoatomic ion transmembrane transporter activity ferrous iron transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding monoatomic cation transmembrane transporter activity iron ion transmembrane transporter activity monoatomic ion transmembrane transporter activity ferrous iron transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process import into cell cellular localization inorganic ion homeostasis iron import into cell homeostatic process transport monoatomic ion transmembrane transport metal ion transport cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process import into cell cellular localization inorganic ion homeostasis iron import into cell homeostatic process transport monoatomic ion transmembrane transport metal ion transport monoatomic cation transmembrane transport localization intracellular iron ion homeostasis intracellular monoatomic cation homeostasis establishment of localization in cell monoatomic ion homeostasis intracellular chemical homeostasis monoatomic ion transport monoatomic cation homeostasis monoatomic cation transport iron ion import across plasma membrane intracellular monoatomic ion homeostasis import across plasma membrane iron ion transport iron ion transmembrane transport establishment of localization inorganic cation import across plasma membrane transmembrane transport cellular homeostasis chemical homeostasis inorganic ion import across plasma membrane transition metal ion transport	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR003373	Ferrous iron transport protein B	Family
A, B, C, D, E A, B, C, D, E, F	IPR011642	Nucleoside transporter/FeoB GTPase, Gate domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR041069	FeoB, cytosolic helical domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR050860	Fe(2+) Transporter FeoB GTPase	Family
A, B, C, D, E A, B, C, D, E, F	IPR030389	FeoB-type guanine nucleotide-binding (G) domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011640	Ferrous iron transport protein B, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.