4TVS

LAP1(aa356-583), H.sapiens, bound to VHH-BS1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
SAbDab Antibody Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth a]	d4tvsa1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Vicugna pacos ) [TaxId: 30538 ],	SCOPe (2.08)
C [auth a]	d4tvsa2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Vicugna pacos ) [TaxId: 30538 ],	SCOPe (2.08)
D [auth b]	d4tvsb1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Vicugna pacos ) [TaxId: 30538 ],	SCOPe (2.08)
D [auth b]	d4tvsb2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Vicugna pacos ) [TaxId: 30538 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LAP1C	e4tvsA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: LAP1C	ECOD (1.6)
B	LAP1C	e4tvsB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: LAP1C	ECOD (1.6)
C [auth a]	V-set_12	e4tvsa1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
D [auth b]	V-set_12	e4tvsb1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.12190	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.40.50.12190	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C [auth a]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth b]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
C [auth a], D [auth b]	Heavy Chain	IGHV1	-	vhh domain bs-1	SAbDab (2024-12-20)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Torsin-1A-interacting protein 1	ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity cytoskeletal protein binding protein binding binding lamin binding ATPase binding enzyme binding	membrane organization cellular component organization nucleus organization organelle organization nuclear envelope organization cellular process cellular component organization or biogenesis endomembrane system organization nuclear membrane organization protein localization localization cellular localization protein localization to organelle cellular macromolecule localization membrane organization cellular component organization nucleus organization organelle organization nuclear envelope organization cellular process cellular component organization or biogenesis endomembrane system organization nuclear membrane organization protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to nucleus protein localization to nuclear envelope positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of ATP-dependent activity biological regulation	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane organelle inner membrane membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane organelle inner membrane nuclear inner membrane
C [auth a], D [auth b]	VHH Domain BS-1	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008662	Torsin-1A-interacting protein 1/2	Family
A, B	IPR046753	Torsin-1A-interacting protein 1/2, AAA+ activator domain	Domain
A, B	IPR038599	LAP1C-like, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR046754	Torsin-1A-interacting protein 1/2, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q5JTV8	autosomal recessive limb-girdle muscular dystrophy type 2Y limb-girdle muscular dystrophy adenoma invasive ductal breast carcinoma lung cancer Malignant neoplasm of breast muscular dystrophy osteosarcoma large cell medulloblastoma lymphoplasmacytic lymphoma muscle tissue disease myopathy ovarian cancer breast cancer malignant ependymoma autosomal recessive limb-girdle muscular dystrophy type 2Y limb-girdle muscular dystrophy adenoma invasive ductal breast carcinoma lung cancer Malignant neoplasm of breast muscular dystrophy osteosarcoma large cell medulloblastoma lymphoplasmacytic lymphoma muscle tissue disease myopathy ovarian cancer breast cancer malignant ependymoma muscular disease oligodendroglioma plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.