4ZZJ

SIRT1/Activator/Substrate Complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8063730	3001728	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SIR2_2nd_1,SIR2_1st	e4zzjA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: SIR2_2nd_1,SIR2_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	TPP-binding domain	CATH (4.3.0)
A	3.30.1600.10	Alpha Beta	2-Layer Sandwich	SIR2/SIRT2 'Small Domain'	SIR2/SIRT2 'Small Domain'	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02146	Sir2 family (SIR2)	Sir2 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Ac-p53	TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone deacetylase binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone deacetylase binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity protein-folding chaperone binding chromatin binding promoter-specific chromatin binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein phosphatase binding phosphatase binding protein phosphatase 2A binding protease binding MDM2/MDM4 family protein binding molecular function activator activity sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding transcription regulatory region nucleic acid binding mRNA 3'-UTR binding RNA binding mRNA binding cation binding transition metal ion binding copper ion binding ion binding metal ion binding small molecule binding core promoter sequence-specific DNA binding 14-3-3 protein binding cis-regulatory region sequence-specific DNA binding protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding protein kinase binding identical protein binding p53 binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein dimerization activity molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity ATP-dependent DNA/DNA annealing activity DNA/DNA annealing activity annealing activity single-stranded DNA binding ATP-dependent activity zinc ion binding disordered domain specific binding protein domain specific binding	catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion biological regulation regulation of mitophagy regulation of catabolic process negative regulation of mitophagy negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy cellular process metabolic process regulation of metabolic process autophagy of mitochondrion regulation of protein stability regulation of biological quality protein stabilization positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process epigenetic regulation of gene expression primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process macromolecule metabolic process membrane organization transport apoptotic mitochondrial changes cell death establishment of localization mitochondrial membrane organization localization organelle organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process regulation of mitochondrial membrane permeability programmed cell death mitochondrion organization mitochondrial transport protein localization cellular localization cellular macromolecule localization macromolecule localization cellular response to stimulus response to stimulus signaling signal transduction by p53 class mediator intracellular signal transduction cell communication apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator signal transduction intrinsic apoptotic signaling pathway multicellular organismal process cellular developmental process regulation of developmental process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis negative regulation of glial cell proliferation regulation of cell development regulation of nervous system development neurogenesis multicellular organism development negative regulation of neurogenesis regulation of glial cell proliferation gliogenesis cell differentiation anatomical structure development regulation of multicellular organismal process negative regulation of nervous system development negative regulation of cell differentiation system development developmental process regulation of multicellular organismal development negative regulation of cell population proliferation cell population proliferation negative regulation of developmental process nervous system development negative regulation of gliogenesis negative regulation of cell development regulation of cell population proliferation glial cell proliferation negative regulation of multicellular organismal process response to stress response to ischemia response to chemical response to antibiotic response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus replicative senescence transcription preinitiation complex assembly regulation of primary metabolic process cellular component biogenesis regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process RNA polymerase II preinitiation complex assembly regulation of DNA-templated transcription regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization positive regulation of DNA-templated transcription protein-DNA complex organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly protein-containing complex assembly regulation of RNA biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly regulation of cellular component biogenesis positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II head development animal organ development brain development cerebellum development central nervous system development metencephalon development hindbrain development tissue remodeling regulation of tissue remodeling positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription regulation of miRNA metabolic process miRNA metabolic process regulation of miRNA transcription regulation of stem cell proliferation negative regulation of stem cell proliferation stem cell proliferation biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cytokine-mediated signaling pathway cellular response to type II interferon response to biotic stimulus interferon-mediated signaling pathway innate immune response cellular response to cytokine stimulus response to external biotic stimulus cell surface receptor signaling pathway immune response response to other organism defense response type II interferon-mediated signaling pathway defense response to symbiont response to external stimulus response to peptide immune system process defense response to other organism hemopoiesis cell activation mononuclear cell differentiation T cell lineage commitment lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation T cell differentiation cell fate commitment leukocyte differentiation reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process fibroblast proliferation DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response DNA repair cellular response to chemical stimulus cellular response to xenobiotic stimulus response to xenobiotic stimulus cellular response to biotic stimulus ER overload response ER-nucleus signaling pathway response to endoplasmic reticulum stress negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process multicellular organism growth developmental growth growth regulation of amide metabolic process negative regulation of small molecule metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of phosphate metabolic process regulation of nucleotide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process negative regulation of pentose-phosphate shunt regulation of phosphorus metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process glucose 6-phosphate metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process regulation of NADP metabolic process amide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process NADP metabolic process NADPH regeneration organophosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of DNA replication DNA replication negative regulation of DNA metabolic process regulation of DNA metabolic process regulation of DNA replication response to osmotic stress response to salt stress cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator DNA damage response, signal transduction by p53 class mediator DNA damage response, signal transduction resulting in transcription signal transduction in response to DNA damage somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process fibroblast apoptotic process regulation of fibroblast apoptotic process negative regulation of ATP-dependent activity regulation of helicase activity regulation of molecular function regulation of ATP-dependent activity regulation of catalytic activity negative regulation of molecular function negative regulation of helicase activity negative regulation of catalytic activity regulation of signal transduction regulation of intrinsic apoptotic signaling pathway regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator regulation of signaling regulation of response to stimulus regulation of cell communication regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to decreased oxygen levels intrinsic apoptotic signaling pathway in response to hypoxia response to hypoxia response to oxygen levels negative regulation of proteolysis regulation of protein metabolic process regulation of proteolysis proteolysis protein metabolic process negative regulation of protein metabolic process positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process leukocyte apoptotic process positive regulation of thymocyte apoptotic process lymphocyte apoptotic process thymocyte apoptotic process regulation of T cell apoptotic process positive regulation of leukocyte apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process positive regulation of lymphocyte apoptotic process positive regulation of T cell apoptotic process regulation of thymocyte apoptotic process T cell apoptotic process positive regulation of reactive oxygen species metabolic process small GTPase-mediated signal transduction Ras protein signal transduction intracellular signaling cassette immune system development hematopoietic or lymphoid organ development bone marrow development skeletal system development bone development response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to UV-C response to UV-C cellular response to light stimulus cellular response to abiotic stimulus cellular response to UV neuron apoptotic process regulation of cellular senescence cellular senescence positive regulation of cellular senescence response to gamma radiation necroptotic process programmed necrotic cell death cell activation involved in immune response leukocyte proliferation immune effector process T cell proliferation involved in immune response T cell activation involved in immune response mononuclear cell proliferation lymphocyte proliferation leukocyte activation involved in immune response lymphocyte activation involved in immune response T cell proliferation oligodendrocyte apoptotic process glial cell apoptotic process regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation peptidyl-tyrosine phosphorylation neuroblast proliferation generation of neurons neural precursor cell proliferation cell cycle G2/M phase transition regulation of cell cycle phase transition regulation of cell cycle process regulation of cell cycle G2/M phase transition cell cycle phase transition cell cycle regulation of cell cycle cell cycle process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability B cell activation B cell lineage commitment B cell differentiation positive regulation of organelle organization regulation of release of cytochrome c from mitochondria positive regulation of release of cytochrome c from mitochondria regulation of organelle organization release of cytochrome c from mitochondria regulation of mitochondrion organization protein complex oligomerization protein tetramerization viral process cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation negative regulation of neural precursor cell proliferation regulation of neuroblast proliferation negative regulation of neuroblast proliferation regulation of neural precursor cell proliferation positive regulation of neuron apoptotic process regulation of neuron apoptotic process cellular response to ionizing radiation regulation of growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport intracellular transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport DNA damage checkpoint signaling negative regulation of cell cycle regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle G1/S phase transition DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis execution phase of apoptosis in utero embryonic development T cell differentiation in thymus heart development cardiac chamber morphogenesis heart morphogenesis circulatory system development cardiac septum development cardiac septum morphogenesis cardiac chamber development animal organ morphogenesis embryonic organ development mRNA transcription mRNA metabolic process negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway rhythmic process entrainment of circadian clock circadian rhythm regulation of circadian rhythm photoperiodism entrainment of circadian clock by photoperiod behavior circadian behavior rhythmic behavior rRNA transcription rRNA metabolic process regulation of fibroblast proliferation negative regulation of fibroblast proliferation positive regulation of cell communication positive regulation of signal transduction positive regulation of apoptotic signaling pathway positive regulation of response to stimulus positive regulation of intracellular signal transduction positive regulation of intrinsic apoptotic signaling pathway positive regulation of signaling cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor regulation of programmed necrotic cell death positive regulation of programmed necrotic cell death post-transcriptional regulation of gene expression RNA processing regulation of miRNA processing miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression negative regulation of miRNA-mediated gene silencing post-transcriptional gene silencing miRNA processing negative regulation of post-transcriptional gene silencing regulation of miRNA-mediated gene silencing negative regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of miRNA processing negative regulation of gene silencing by regulatory ncRNA regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of post-transcriptional gene silencing negative regulation of G1 to G0 transition regulation of G1 to G0 transition G1 to G0 transition cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound response to actinomycin D cellular response to oxygen-containing compound cellular response to actinomycin D cellular response to antibiotic cellular response to oxidative stress cellular response to chemical stress oxidative stress-induced premature senescence response to oxidative stress stress-induced premature senescence cellular response to gamma radiation chromosome organization embryonic morphogenesis gastrulation regulation of cellular response to stress regulation of response to stress regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of telomere maintenance telomere organization negative regulation of telomere maintenance via telomerase regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening negative regulation of chromosome organization negative regulation of cellular component organization regulation of chromosome organization regulation of telomere maintenance via telomere lengthening telomere maintenance DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening telomere maintenance via telomerase regulation of telomere maintenance via telomerase negative regulation of organelle organization glucose catabolic process to lactate via pyruvate oxoacid metabolic process organic acid metabolic process lactate metabolic process glycolytic fermentation negative regulation of carbohydrate metabolic process hexose catabolic process hexose metabolic process glucose catabolic process monocarboxylic acid metabolic process glucose catabolic process to lactate monosaccharide catabolic process small molecule catabolic process monosaccharide metabolic process energy derivation by oxidation of organic compounds negative regulation of fermentation organic hydroxy compound metabolic process fermentation regulation of glucose catabolic process to lactate via pyruvate regulation of glucose metabolic process carboxylic acid metabolic process negative regulation of glucose catabolic process to lactate via pyruvate regulation of fermentation glucose metabolic process determination of adult lifespan stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress mitochondrial genome maintenance mitochondrial DNA metabolic process mitochondrial DNA repair intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage double-strand break repair	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen germ cell nucleus protein-containing complex replication fork chromosome site of double-strand break site of DNA damage mitochondrion mitochondrial matrix transcription regulator complex chromatin nuclear periphery nuclear matrix centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton nucleoplasm transcription repressor complex endoplasmic reticulum endomembrane system nuclear body PML body
A	NAD-dependent protein deacetylase sirtuin-1	protein binding binding histone binding deacetylase activity protein lysine deacetylase activity catalytic activity, acting on a protein acyltransferase activity deacylase activity histone deacetylase activity, NAD-dependent transferase activity histone H3K14 deacetylase activity, NAD-dependent NAD-dependent protein lysine deacylase activity histone deacetylase activity histone H3K deacetylase activity protein binding binding histone binding deacetylase activity protein lysine deacetylase activity catalytic activity, acting on a protein acyltransferase activity deacylase activity histone deacetylase activity, NAD-dependent transferase activity histone H3K14 deacetylase activity, NAD-dependent NAD-dependent protein lysine deacylase activity histone deacetylase activity histone H3K deacetylase activity NAD-dependent protein lysine deacetylase activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity protein decrotonylase activity histone decrotonylase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds NAD-dependent protein decrotonylase activity histone modifying activity NAD-dependent histone decrotonylase activity chromatin binding promoter-specific chromatin binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase binding cation binding ion binding metal ion binding small molecule binding histone H3K9 deacetylase activity, NAD-dependent keratin filament binding intermediate filament binding histone H4K deacetylase activity histone H4K12 deacetylase activity, hydrolytic mechanism transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity transcription factor binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding histone H4K16 deacetylase activity, NAD-dependent NAD+ binding NAD binding nucleotide binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding HLH domain binding protein domain specific binding bHLH transcription factor binding identical protein binding p53 binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription coactivator activity NAD-dependent protein-lysine depropionylase activity NAD-dependent protein lysine delactylase activity	positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process regulation of transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization cholesterol transport cholesterol efflux developmental process fat cell differentiation regulation of cellular process cellular developmental process regulation of developmental process regulation of cell differentiation regulation of brown fat cell differentiation brown fat cell differentiation cell differentiation cellular process regulation of fat cell differentiation muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process apoptotic process programmed cell death neutral lipid metabolic process triglyceride metabolic process primary metabolic process metabolic process glycerolipid metabolic process triglyceride mobilization acylglycerol metabolic process lipid metabolic process response to stimulus immune response regulation of adaptive immune response adaptive immune response positive regulation of response to stimulus regulation of response to stimulus positive regulation of immune response immune system process regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process cellular response to stimulus DNA repair-dependent chromatin remodeling cellular component organization cellular response to stress DNA damage response chromatin organization response to stress chromatin remodeling cellular component organization or biogenesis response to nutrient levels behavioral response to starvation response to starvation peptidyl-lysine acetylation peptidyl-lysine modification protein acylation protein acetylation macromolecule modification peptidyl-amino acid modification protein metabolic process macromolecule metabolic process protein modification process muscle structure development animal organ development anatomical structure development muscle organ development leukocyte apoptotic process macrophage apoptotic process positive regulation of myeloid cell apoptotic process positive regulation of macrophage apoptotic process positive regulation of leukocyte apoptotic process positive regulation of cellular process myeloid cell apoptotic process regulation of leukocyte apoptotic process positive regulation of programmed cell death positive regulation of apoptotic process regulation of macrophage apoptotic process inflammatory cell apoptotic process regulation of myeloid cell apoptotic process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process regulation of cellular response to stress nucleobase-containing compound metabolic process positive regulation of DNA repair regulation of response to stress regulation of nucleobase-containing compound metabolic process DNA repair positive regulation of nucleobase-containing compound metabolic process DNA metabolic process nucleic acid metabolic process regulation of DNA repair positive regulation of DNA metabolic process regulation of DNA metabolic process regulation of biosynthetic process rhythmic process circadian regulation of gene expression circadian rhythm gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process cellular response to nutrient levels cellular response to starvation ovulation cycle process multicellular organismal process ovulation sexual reproduction reproductive process sex differentiation development of primary female sexual characteristics female gamete generation developmental process involved in reproduction gamete generation ovulation from ovarian follicle ovulation cycle multicellular organism development development of primary sexual characteristics reproductive structure development system development gonad development reproductive system development female gonad development multicellular organismal reproductive process female sex differentiation regulation of immune effector process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of myeloid leukocyte cytokine production involved in immune response cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of gene expression positive regulation of cytokine production involved in immune response positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of production of molecular mediator of immune response positive regulation of cytokine production positive regulation of macrophage cytokine production macrophage cytokine production signaling response to cytokine cytokine-mediated signaling pathway cellular response to leptin stimulus cell communication cellular response to endogenous stimulus response to hormone cellular response to cytokine stimulus response to leptin signal transduction cellular response to hormone stimulus leptin-mediated signaling pathway cell surface receptor signaling pathway response to endogenous stimulus response to peptide cellular response to chemical stimulus response to chemical response to light stimulus cellular response to environmental stimulus cellular response to light stimulus cellular response to radiation response to UV UV-damage excision repair response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of molecular function positive regulation of protein modification process regulation of cAMP-dependent protein kinase activity positive regulation of protein kinase activity positive regulation of cAMP-dependent protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation regulation of lipid storage lipid storage maintenance of location negative regulation of biological process RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process nucleobase-containing compound biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process smooth muscle cell differentiation positive regulation of smooth muscle cell differentiation regulation of smooth muscle cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation positive regulation of developmental process regulation of muscle cell differentiation positive regulation of cell differentiation response to hydrogen peroxide response to oxidative stress response to oxygen-containing compound response to reactive oxygen species cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway regulation of double-strand break repair double-strand break repair positive regulation of double-strand break repair negative regulation of developmental process negative regulation of fat cell differentiation negative regulation of cell differentiation monosaccharide metabolic process gluconeogenesis regulation of small molecule metabolic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process positive regulation of gluconeogenesis carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process hexose biosynthetic process positive regulation of glucose metabolic process regulation of gluconeogenesis positive regulation of carbohydrate metabolic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process glucose metabolic process negative regulation of DNA-binding transcription factor activity negative regulation of molecular function regulation of DNA-binding transcription factor activity negative regulation of programmed cell death negative regulation of apoptotic process regulation of endodeoxyribonuclease activity regulation of hydrolase activity regulation of deoxyribonuclease activity regulation of nuclease activity negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction DNA damage response, signal transduction by p53 class mediator intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator regulation of signaling negative regulation of response to stimulus signal transduction by p53 class mediator negative regulation of signal transduction regulation of cell communication signal transduction in response to DNA damage negative regulation of ATP-dependent activity regulation of helicase activity regulation of ATP-dependent activity negative regulation of helicase activity negative regulation of catalytic activity multicellular organismal-level homeostasis homeostatic process energy homeostasis sterol homeostasis chemical homeostasis cholesterol homeostasis lipid homeostasis regulation of transcription by glucose negative regulation of NF-kappaB transcription factor activity negative regulation of phosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of phosphorylation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation cellular response to tumor necrosis factor response to tumor necrosis factor regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion fatty acid homeostasis myeloid leukocyte differentiation hemopoiesis macrophage differentiation cell development mononuclear cell differentiation myeloid cell differentiation leukocyte differentiation positive regulation of autophagy macroautophagy autophagy regulation of autophagy regulation of macroautophagy positive regulation of macroautophagy process utilizing autophagic mechanism regulation of cellular senescence cellular senescence positive regulation of cellular senescence response to peptide hormone response to insulin response to nitrogen compound heterochromatin formation epigenetic regulation of gene expression negative regulation of gene expression negative regulation of gene expression, epigenetic regulation of MHC class II biosynthetic process MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process negative regulation of triglyceride metabolic process neutral lipid biosynthetic process regulation of triglyceride metabolic process regulation of lipid metabolic process lipid biosynthetic process negative regulation of lipid biosynthetic process acylglycerol biosynthetic process negative regulation of triglyceride biosynthetic process triglyceride biosynthetic process regulation of triglyceride biosynthetic process glycerolipid biosynthetic process regulation of lipid biosynthetic process negative regulation of lipid metabolic process regulation of steroid biosynthetic process oxoacid metabolic process ketone metabolic process steroid metabolic process organic hydroxy compound metabolic process organic acid metabolic process organic acid biosynthetic process regulation of bile acid metabolic process carboxylic acid biosynthetic process steroid biosynthetic process bile acid biosynthetic process monocarboxylic acid biosynthetic process regulation of steroid metabolic process regulation of bile acid biosynthetic process carboxylic acid metabolic process regulation of ketone metabolic process bile acid metabolic process organic hydroxy compound biosynthetic process monocarboxylic acid metabolic process endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation DNA synthesis involved in DNA repair DNA biosynthetic process negative regulation of protein modification process negative regulation of protein metabolic process negative regulation of protein acetylation regulation of protein acetylation spermatogenesis male gamete generation stress-induced premature senescence cellular homeostasis glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis establishment of organelle localization mitotic metaphase chromosome alignment negative regulation of cell cycle regulation of attachment of mitotic spindle microtubules to kinetochore establishment of localization in cell cell cycle chromosome segregation regulation of cell cycle process attachment of mitotic spindle microtubules to kinetochore sister chromatid segregation regulation of chromosome organization negative regulation of attachment of mitotic spindle microtubules to kinetochore regulation of organelle organization regulation of mitotic sister chromatid segregation mitotic cell cycle process establishment of chromosome localization negative regulation of attachment of spindle microtubules to kinetochore regulation of chromosome segregation cellular localization regulation of cellular component organization mitotic cell cycle metaphase chromosome alignment chromosome localization organelle localization mitotic sister chromatid segregation regulation of attachment of spindle microtubules to kinetochore regulation of cell cycle cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission chromosome organization negative regulation of cell cycle process organelle organization nuclear division negative regulation of chromosome segregation regulation of sister chromatid segregation nuclear chromosome segregation regulation of metaphase plate congression protein destabilization regulation of protein stability regulation of biological quality cellular response to glucose starvation response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to hypoxia response to oxygen levels microtubule organizing center organization regulation of centrosome cycle microtubule cytoskeleton organization regulation of microtubule-based process centrosome duplication centrosome cycle regulation of centrosome duplication microtubule-based process cytoskeleton organization response to ionizing radiation cellular response to ionizing radiation protein ubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal nucleus localization maintenance of organelle location maintenance of nucleus location maintenance of location in cell triglyceride homeostasis acylglycerol homeostasis intracellular triglyceride homeostasis cellular response to nitrogen compound positive regulation of cell communication positive regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway positive regulation of cellular response to insulin stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway cellular response to peptide hormone stimulus cellular response to oxygen-containing compound cellular response to insulin stimulus positive regulation of signaling negative regulation of transforming growth factor beta receptor signaling pathway regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of TOR signaling TOR signaling regulation of TOR signaling protein deacylation macromolecule deacylation protein deacetylation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction response to ketone response to lipid negative regulation of cellular response to testosterone stimulus response to testosterone cellular response to ketone response to organic cyclic compound cellular response to testosterone stimulus cellular response to organic cyclic compound regulation of cellular response to testosterone stimulus cellular response to lipid positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cellular response to heat regulation of cellular response to heat response to heat response to temperature stimulus white fat cell differentiation regulation of mitotic cell cycle blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development connective tissue development adipose tissue development positive regulation of adipose tissue development tissue development regulation of adipose tissue development negative regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction intracellular receptor signaling pathway peroxisome proliferator activated receptor signaling pathway regulation of peroxisome proliferator activated receptor signaling pathway nuclear receptor-mediated signaling pathway positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process constitutive heterochromatin formation DNA methylation-dependent constitutive heterochromatin formation regulation of response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of apoptotic signaling pathway regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of response to endoplasmic reticulum stress response to endoplasmic reticulum stress positive regulation of intrinsic apoptotic signaling pathway positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide cellular response to reactive oxygen species intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway single strand break repair regulation of vasculature development regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis negative regulation of cellular senescence negative regulation of peptidyl-lysine acetylation regulation of peptidyl-lysine acetylation prostaglandin metabolic process negative regulation of small molecule metabolic process unsaturated fatty acid metabolic process prostaglandin biosynthetic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process regulation of prostaglandin biosynthetic process icosanoid metabolic process regulation of unsaturated fatty acid biosynthetic process negative regulation of prostaglandin biosynthetic process prostanoid metabolic process icosanoid biosynthetic process negative regulation of fatty acid biosynthetic process prostanoid biosynthetic process fatty acid metabolic process negative regulation of fatty acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process hormone-mediated signaling pathway negative regulation of intracellular steroid hormone receptor signaling pathway response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway regulation of androgen receptor signaling pathway negative regulation of androgen receptor signaling pathway nucleotide-excision repair pyrimidine dimer repair pyrimidine dimer repair by nucleotide-excision repair nucleolar chromatin organization rDNA heterochromatin formation nucleus organization nucleolus organization facultative heterochromatin formation protein depropionylation response to leukemia inhibitory factor cellular response to leukemia inhibitory factor	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol membrane-enclosed lumen intracellular membraneless organelle membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol membrane-enclosed lumen intracellular membraneless organelle nucleolus intracellular organelle lumen organelle lumen membraneless organelle nuclear lumen protein-containing complex chromatin silencing complex nuclear protein-containing complex rDNA heterochromatin chromatin chromosome heterochromatin fibrillar center euchromatin eNoSc complex organelle inner membrane nuclear membrane membrane nuclear inner membrane organelle membrane mitochondrion nucleoplasm nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B	IPR002117	p53 tumour suppressor family	Family
B	IPR013872	p53 transactivation domain	Domain
B	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
B	IPR011615	p53, DNA-binding domain	Domain
B	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B	IPR010991	p53, tetramerisation domain	Domain
B	IPR040926	Cellular tumor antigen p53, transactivation domain 2	Domain
A	IPR003000	Sirtuin family	Family
A	IPR026590	Sirtuin family, catalytic core domain	Domain
A	IPR026591	Sirtuin, catalytic core small domain superfamily	Homologous Superfamily
A	IPR029035	DHS-like NAD/FAD-binding domain superfamily	Homologous Superfamily
A	IPR050134	NAD-dependent sirtuin protein deacylases	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P04637	Li-Fraumeni syndrome melanoma cholangiocarcinoma choroid plexus papilloma angiosarcoma B-cell chronic lymphocytic leukemia adrenal cortex carcinoma esophageal cancer adrenocortical carcinoma, hereditary malignant glioma renal cell carcinoma urinary bladder cancer skin basal cell carcinoma squamous cell carcinoma psoriasis Li-Fraumeni syndrome melanoma cholangiocarcinoma choroid plexus papilloma angiosarcoma B-cell chronic lymphocytic leukemia adrenal cortex carcinoma esophageal cancer adrenocortical carcinoma, hereditary malignant glioma renal cell carcinoma urinary bladder cancer skin basal cell carcinoma squamous cell carcinoma psoriasis osteosarcoma head and neck squamous cell carcinoma esophageal squamous cell carcinoma small cell lung carcinoma amyotrophic lateral sclerosis nasopharyngeal carcinoma hypertensive disorder T-cell non-Hodgkin lymphoma Balkan nephropathy adenoma choroid plexus carcinoma hypertrophic cardiomyopathy colorectal cancer kidney Wilms tumor glioblastoma skin neoplasm gallbladder cancer thymoma cancer malignant mesothelioma transitional cell carcinoma non-small cell lung carcinoma cutaneous melanoma esophageal adenocarcinoma primary cutaneous T-cell non-Hodgkin lymphoma breast adenocarcinoma male infertility Neoplasm Metastasis thyroid gland carcinoma keratosis salivary gland adenoid cystic carcinoma astrocytic tumor giant cell glioblastoma carotid artery disease sarcomatoid carcinoma central nervous system cancer ovarian cancer Li-Fraumeni syndrome 1 Sezary syndrome liver cancer papillary renal cell carcinoma small cell carcinoma essential thrombocythemia spindle cell sarcoma microcystic adenoma hepatocellular carcinoma brain ischemia clear cell adenocarcinoma familial pancreatic carcinoma breast cancer collecting duct carcinoma follicular thyroid adenoma thymic carcinoma gastric cancer thyroid adenoma carcinoma tubular adenocarcinoma demyelinating disease sarcomatoid renal cell carcinoma gliosarcoma penile neoplasm adrenal gland cancer polyploidy lung cancer exocrine pancreatic carcinoma mixed glioma myelodysplastic syndrome prostate cancer female infertility breast carcinoma malignant colon neoplasm intrahepatic cholangiocarcinoma vulvar lichen sclerosus sarcoma adenocarcinoma schizophrenia granular cell carcinoma adenoid cystic carcinoma skin cancer papillary adenoma chromophobe renal cell carcinoma lung carcinoma brain glioma mouth disease chronic obstructive pulmonary disease eye disease prostate disease breast disease colorectal adenocarcinoma pulmonary emphysema malignant ependymoma gallbladder neoplasm thymus neoplasm uterine corpus leiomyoma renal carcinoma neuroblastoma acute kidney failure cribriform carcinoma triple-negative breast carcinoma oligodendroglioma acute megakaryoblastic leukemia glioma susceptibility 1 undifferentiated carcinoma granulomatous slack skin disease urinary bladder neoplasm ovarian neoplasm skin disease benign neoplasm of pancreas head and neck carcinoma childhood acute lymphoblastic leukemia bile duct cancer medulloblastoma penile cancer polycystic ovary syndrome lung benign neoplasm bone osteosarcoma lung disease hereditary breast ovarian cancer syndrome primitive neuroectodermal tumor lymphatic system disease subependymal giant cell astrocytoma nasopharyngeal carcinoma, susceptibility to, 1 Burkitt lymphoma neoplasm of esophagus intestinal disease ischemic disease uterine disease congenital anemia neurodegenerative disease cribriform carcinoma of breast SAPHO syndrome atypical teratoid rhabdoid tumor oral cavity neoplasm acute myeloid leukemia ovarian carcinoma Li-Fraumeni syndrome 2 basal cell carcinoma, susceptibility to, 7 malignant pancreatic neoplasm Hantavirus hemorrhagic fever with renal syndrome, Puumala virus type urogenital neoplasm cervical cancer pancreatic neoplasm epithelioid sarcoma benign urinary system neoplasm head and neck neoplasm uterine cervix carcinoma in situ papilloma liver neoplasm esophageal disease bone disease hematopoietic and lymphoid system neoplasm adult hepatocellular carcinoma brain disease chromosome 17p deletion stomach disease hereditary diffuse gastric adenocarcinoma clear cell renal carcinoma nasopharyngeal neoplasm IgA glomerulonephritis colonic neoplasm anemia colorectal carcinoma pustulosis palmaris et plantaris gastric neoplasm thyroid cancer rheumatoid arthritis kidney disease large cell medulloblastoma autoimmune disease glioma urinary bladder disease ovarian disease endometriosis benign colon neoplasm head and neck cancer cervical carcinoma adrenal carcinoma liver disease skin pigmented basal cell carcinoma choroid plexus cancer pilocytic astrocytoma bone marrow disease metabolic syndrome X hepatoblastoma
A	Pharos: Q96EB6	metabolic syndrome X diabetic retinopathy atherosclerosis type 2 diabetes mellitus obesity disorder Ceroid lipofuscinosis, neuronal 1, infantile streptococcal pneumonia experimental autoimmune encephalomyelitis non-alcoholic fatty liver disease autoimmune disease glucose intolerance osteosarcoma HIV infectious disease breast carcinoma colitis metabolic syndrome X diabetic retinopathy atherosclerosis type 2 diabetes mellitus obesity disorder Ceroid lipofuscinosis, neuronal 1, infantile streptococcal pneumonia experimental autoimmune encephalomyelitis non-alcoholic fatty liver disease autoimmune disease glucose intolerance osteosarcoma HIV infectious disease breast carcinoma colitis diabetes mellitus Wallerian degeneration neurodegenerative disease brain infarction pneumonia prostate cancer retinal disease congestive heart failure demyelinating disease atrial fibrillation heart disease pneumonitis breast cancer hyperglycemia schizophrenia acute kidney failure systemic sclerosis adrenal cortex carcinoma fatty liver disease brain cancer heart failure liver disease alcohol abuse ovarian cancer human African trypanosomiasis cancer maturity-onset diabetes of the young thrombotic disease arteriosclerosis disorder bipolar disorder palsy

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	ALY	Parent Component: LYS RESID: AA0055 PSI-MOD : N6-acetyl-L-lysine MOD:00064
B	NLE	Parent Component: LEU RESID: AA0055

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.