5B0O | pdb_00005b0o

Structure of the FliH-FliI complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018280	3001034	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RecA-like P-loop NTPases	8018276	3002019	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018280	3001034	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RecA-like P-loop NTPases	8018276	3002019	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018280	3001034	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RecA-like P-loop NTPases	8018276	3002019	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ATP synthase alpha/beta N-terminal domain-like	8018280	3001034	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	RecA-like P-loop NTPases	8018276	3002019	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	UNK_F_TYPE	e5b0oD3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: UNK_F_TYPE	ECOD (1.6)
D	FliI	e5b0oD1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: FliI	ECOD (1.6)
D	ATP-synt_ab	e5b0oD2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
C	UNK_F_TYPE	e5b0oC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: UNK_F_TYPE	ECOD (1.6)
C	FliI	e5b0oC2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: FliI	ECOD (1.6)
C	ATP-synt_ab	e5b0oC3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
B	UNK_F_TYPE	e5b0oB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: UNK_F_TYPE	ECOD (1.6)
B	FliI	e5b0oB3	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: FliI	ECOD (1.6)
B	ATP-synt_ab	e5b0oB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
A	UNK_F_TYPE	e5b0oA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: UNK_F_TYPE	ECOD (1.6)
A	FliI	e5b0oA2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: FliI	ECOD (1.6)
A	ATP-synt_ab	e5b0oA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
L	FliH	e5b0oL1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: FliH	ECOD (1.6)
L	fliH_like	e5b0oL2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: fliH_like	ECOD (1.6)
K	FliH	e5b0oK2	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: FliH	ECOD (1.6)
K	fliH_like	e5b0oK1	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: fliH_like	ECOD (1.6)
J	FliH	e5b0oJ1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: FliH	ECOD (1.6)
J	fliH_like	e5b0oJ2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: fliH_like	ECOD (1.6)
I	FliH	e5b0oI2	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: FliH	ECOD (1.6)
I	fliH_like	e5b0oI1	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: fliH_like	ECOD (1.6)
H	FliH	e5b0oH1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: FliH	ECOD (1.6)
H	fliH_like	e5b0oH2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: fliH_like	ECOD (1.6)
G	FliH	e5b0oG1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: FliH	ECOD (1.6)
G	fliH_like	e5b0oG2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: fliH_like	ECOD (1.6)
F	FliH	e5b0oF1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: FliH	ECOD (1.6)
E	FliH	e5b0oE1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: FliH	ECOD (1.6)
E	fliH_like	e5b0oE2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: fliH_like	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
A, B, C, D	PF18269	T3SS EscN ATPase C-terminal domain (T3SS_ATPase_C)	T3SS EscN ATPase C-terminal domain	This is the C-terminal domain of the EscN protein family of ATPases that form part of the Type III secretion system (T3SS) present in Escherichia coli. T3SS is a macromolecular complex that creates a syringe-like apparatus extending from the bacteria ...	This is the C-terminal domain of the EscN protein family of ATPases that form part of the Type III secretion system (T3SS) present in Escherichia coli. T3SS is a macromolecular complex that creates a syringe-like apparatus extending from the bacterial cytosol across three membranes to the eukaryotic cytosol. This process is essential for pathogenicity. EscN is a functionally unique ATPase that provides an inner-membrane recognition gate for the T3SS chaperone-virulence effector complexes as well as a potential source of energy for their subsequent secretion.The C-terminal domain of T3SS ATPases mediates binding with multiple contact points along the chaperone [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Flagellum-specific ATP synthase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding	monoatomic cation transmembrane transport transmembrane transport localization transport proton transmembrane transport monoatomic ion transmembrane transport monoatomic ion transport cellular process monoatomic cation transport establishment of localization ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process monoatomic cation transmembrane transport transmembrane transport localization transport proton transmembrane transport monoatomic ion transmembrane transport monoatomic ion transport cellular process monoatomic cation transport establishment of localization ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process organelle assembly cell projection organization bacterial-type flagellum assembly membraneless organelle assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular component organization or biogenesis cell projection assembly bacterial-type flagellum-dependent cell motility cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility establishment of protein localization nitrogen compound transport secretion protein secretion by the type III secretion system establishment of protein localization to extracellular region export from cell protein secretion protein localization to extracellular region secretion by cell protein transmembrane transport protein transport macromolecule localization intracellular protein localization	cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex type III protein secretion system complex
E, F, G, H, I E, F, G, H, I, J, K, L	Flagellar assembly protein FliH	cytoskeletal motor activity	cellular component organization bacterial-type flagellum organization organelle organization cell projection organization cellular process cellular component organization or biogenesis bacterial-type flagellum-dependent cell motility cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility localization establishment of protein localization nitrogen compound transport protein transport cellular component organization bacterial-type flagellum organization organelle organization cell projection organization cellular process cellular component organization or biogenesis bacterial-type flagellum-dependent cell motility cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility localization establishment of protein localization nitrogen compound transport protein transport transport macromolecule localization intracellular protein localization establishment of localization	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell projection organelle membraneless organelle bacterial-type flagellum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR040627	T3SS EscN ATPase, C-terminal	Domain
A, B, C, D	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
A, B, C, D	IPR050053	ATPase alpha/beta chains	Family
A, B, C, D	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
A, B, C, D	IPR003593	AAA+ ATPase domain	Domain
A, B, C, D	IPR005714	ATPase, type III secretion system, FliI/YscN	Family
A, B, C, D	IPR020005	Flagellar export ATPase FliI, clade 1	Family
A, B, C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E, F, G, H, I E, F, G, H, I, J, K, L	IPR051472	Type III Secretion System Stator and Flagellar Assembly	Family
E, F, G, H, I E, F, G, H, I, J, K, L	IPR018035	Flagellar assembly protein FliH/Type III secretion system HrpE	Domain
E, F, G, H, I E, F, G, H, I, J, K, L	IPR000563	Flagellar assembly protein FliH	Family

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Structure of the FliH-FliI complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

5B0O | pdb_00005b0o