5DSE | pdb_00005dse

Crystal Structure of the TTC7B/Hyccin Complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2 Family	Hyccin-like	8045610	4004564	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Hyccin repeat-like	8091062	3002479	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Hyccin repeat-like	8091061	3002479	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Hyccin repeat-like	8091062	3002479	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Hyccin	e5dseD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Hyccin	ECOD (1.6)
B	Hyccin	e5dseB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Hyccin	ECOD (1.6)
C	TPR_15	e5dseC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_15	ECOD (1.6)
A	TPR_15	e5dseA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_15	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
A, C	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat
A, C	PF13424	Tetratricopeptide repeat (TPR_12)	Tetratricopeptide repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D	Hyccin	-	myelination developmental process multicellular organism development multicellular organismal process axon ensheathment ensheathment of neurons anatomical structure development cellular process nervous system development system development localization protein localization to cell periphery cellular localization protein localization to plasma membrane myelination developmental process multicellular organism development multicellular organismal process axon ensheathment ensheathment of neurons anatomical structure development cellular process nervous system development system development localization protein localization to cell periphery cellular localization protein localization to plasma membrane macromolecule localization intracellular protein localization localization within membrane protein localization to membrane phosphatidylinositol metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane cell projection neuron projection plasma membrane bounded cell projection
A, C	Tetratricopeptide repeat protein 7B	-	localization protein localization to cell periphery cellular localization protein localization to plasma membrane macromolecule localization cellular process intracellular protein localization localization within membrane protein localization to membrane phosphatidylinositol metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process localization protein localization to cell periphery cellular localization protein localization to plasma membrane macromolecule localization cellular process intracellular protein localization localization within membrane protein localization to membrane phosphatidylinositol metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR018619	Hyccin	Family
A, C	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, C	IPR045819	Tetratricopeptide repeat protein 7, N-terminal	Domain
A, C	IPR019734	Tetratricopeptide repeat	Repeat
A, C	IPR051722	Endocytosis and PI4K-regulating protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D	Pharos: Q9BYI3	hypomyelinating leukodystrophy 5 leukodystrophy intellectual disability cataract Mental deficiency pancreatic intraductal papillary-mucinous carcinoma peripheral neuropathy Sjogren syndrome amyotrophic lateral sclerosis breast carcinoma substance-related disorder drug dependence ductal breast carcinoma in situ hereditary spastic paraplegia invasive ductal breast carcinoma hypomyelinating leukodystrophy 5 leukodystrophy intellectual disability cataract Mental deficiency pancreatic intraductal papillary-mucinous carcinoma peripheral neuropathy Sjogren syndrome amyotrophic lateral sclerosis breast carcinoma substance-related disorder drug dependence ductal breast carcinoma in situ hereditary spastic paraplegia invasive ductal breast carcinoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor substance dependence facioscapulohumeral muscular dystrophy medulloblastoma myopathy ovarian cancer peripheral nervous system disease substance abuse breast cancer ulcerative colitis glioblastoma lung carcinoma
A, C	Pharos: Q86TV6	astrocytic tumor exocrine pancreatic carcinoma lung adenocarcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma ductal breast carcinoma in situ astrocytic tumor exocrine pancreatic carcinoma lung adenocarcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma ductal breast carcinoma in situ invasive ductal breast carcinoma malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.