5GGP

Crystal structure of N-terminal domain of human protein O-mannose beta-1,2-N-acetylglucosaminyltransferase in complex with GlcNAc-beta1,2-Man-peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	FAM3B/PANDER-like	8055726	3002300	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	FAM3B/PANDER-like	8055726	3002300	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ILEI	e5ggpA1	A: a+b two layers	X: FAM3 superfamily (From Topology)	H: FAM3 superfamily (From Topology)	T: FAM3 superfamily	F: ILEI	ECOD (1.6)
B	ILEI	e5ggpB1	A: a+b two layers	X: FAM3 superfamily (From Topology)	H: FAM3 superfamily (From Topology)	T: FAM3 superfamily	F: ILEI	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF15711	Interleukin-like EMT inducer (ILEI)	Interleukin-like EMT inducer	ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fib ...	ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localisation, is associated with EMT in human cancerous tissue [1]. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	binding carbohydrate binding UDP-glycosyltransferase activity beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity glycosyltransferase activity catalytic activity, acting on a protein catalytic activity, acting on a glycoprotein acetylglucosaminyltransferase activity transferase activity hexosyltransferase activity catalytic activity cation binding manganese ion binding transition metal ion binding binding carbohydrate binding UDP-glycosyltransferase activity beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity glycosyltransferase activity catalytic activity, acting on a protein catalytic activity, acting on a glycoprotein acetylglucosaminyltransferase activity transferase activity hexosyltransferase activity catalytic activity cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding	biosynthetic process metabolic process cellular process macromolecule metabolic process gene expression macromolecule biosynthetic process localization localization of cell multicellular organismal process system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus biosynthetic process metabolic process cellular process macromolecule metabolic process gene expression macromolecule biosynthetic process localization localization of cell multicellular organismal process system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus developmental process head development forebrain development animal organ development brain development nervous system development dentate gyrus development pallium development multicellular organism development central nervous system development anatomical structure development telencephalon development hippocampus development limbic system development system development myelination axon ensheathment ensheathment of neurons carbohydrate derivative biosynthetic process protein mannosylation glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation protein O-linked mannosylation glycosylation mannosylation macromolecule modification macromolecule glycosylation protein O-linked glycosylation protein metabolic process protein modification process O-glycan processing response to stimulus defense response response to stress reactive gliosis inflammatory response neuroinflammatory response cellular component organization extracellular matrix organization cellular component organization or biogenesis basement membrane organization extracellular structure organization external encapsulating structure organization	cellular anatomical structure membrane membrane-bounded organelle Golgi membrane intracellular anatomical structure Golgi apparatus intracellular membrane-bounded organelle endomembrane system intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane
C, D	10-mer Peptide from Dystroglycan	structural molecule activity structural constituent of muscle extracellular matrix binding binding protein binding laminin binding protein-containing complex binding virus receptor activity exogenous protein binding cation binding ion binding calcium ion binding metal ion binding small molecule binding structural molecule activity structural constituent of muscle extracellular matrix binding binding protein binding laminin binding protein-containing complex binding virus receptor activity exogenous protein binding cation binding ion binding calcium ion binding metal ion binding small molecule binding cytoskeletal protein binding vinculin binding dystroglycan binding tubulin binding alpha-actinin binding actinin binding SH2 domain binding protein domain specific binding actin binding laminin-1 binding	response to stimulus response to activity response to muscle activity cellular response to stimulus response to sterol response to lipid response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound response to cholesterol cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to chemical response to stimulus response to activity response to muscle activity cellular response to stimulus response to sterol response to lipid response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound response to cholesterol cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to chemical cellular response to lipid cellular process cellular response to sterol cellular response to cholesterol response to organic cyclic compound developmental process tissue morphogenesis anatomical structure morphogenesis epithelium development anatomical structure development morphogenesis of an epithelium tissue development morphogenesis of an epithelial sheet regulation of biological process regulation of cellular process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process cell-substrate adhesion positive regulation of cell-matrix adhesion cell adhesion cell-matrix adhesion positive regulation of cell-substrate adhesion regulation of cell-matrix adhesion positive regulation of cellular process multicellular organismal process cellular developmental process peripheral nervous system axon ensheathment peripheral nervous system development cell development nervous system development glial cell development myelination multicellular organism development neurogenesis Schwann cell development gliogenesis axon ensheathment ensheathment of neurons glial cell differentiation cell differentiation myelination in peripheral nervous system Schwann cell differentiation system development calcium-dependent cell-matrix adhesion cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis microtubule anchoring cytoskeleton organization heart development heart morphogenesis animal organ development circulatory system development animal organ morphogenesis regulation of embryonic development regulation of multicellular organismal development regulation of gastrulation regulation of developmental process embryonic morphogenesis embryo development gastrulation regulation of multicellular organismal process regulation of anatomical structure morphogenesis negative regulation of locomotion regulation of cell motility negative regulation of biological process regulation of locomotion negative regulation of cellular process regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction muscle structure development skeletal muscle organ development muscle attachment muscle organ development nerve maturation nerve development anatomical structure maturation developmental maturation regulation of muscle adaptation system process regulation of system process regulation of muscle system process muscle system process response to muscle inactivity response to stimulus involved in regulation of muscle adaptation muscle adaptation response to denervation involved in regulation of muscle adaptation response to muscle inactivity involved in regulation of muscle adaptation response to inactivity wound healing blood vessel morphogenesis tube development angiogenesis involved in wound healing angiogenesis vasculature development tube morphogenesis response to stress anatomical structure formation involved in morphogenesis response to wounding blood vessel development regulation of embryonic cell shape regulation of cell shape cell morphogenesis regulation of cell morphogenesis regulation of biological quality response to hormone response to endogenous stimulus response to peptide hormone response to nitrogen compound protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization regulation of epithelial to mesenchymal transition regulation of cell differentiation mesenchyme development epithelial to mesenchymal transition mesenchymal cell differentiation branching morphogenesis of an epithelial tube respiratory tube development lung morphogenesis lung development respiratory system development epithelial tube morphogenesis morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium regulation of cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization commissural neuron axon guidance axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell projection morphogenesis neuron differentiation neuron projection morphogenesis plasma membrane bounded cell projection organization axon guidance axon development cell morphogenesis involved in neuron differentiation generation of neurons neuron projection guidance neuron development extracellular matrix organization basement membrane organization extracellular structure organization external encapsulating structure organization regulation of myelination regulation of nervous system development positive regulation of myelination positive regulation of nervous system process nervous system process regulation of nervous system process positive regulation of multicellular organismal process regulation of MAPK cascade MAPK cascade negative regulation of MAPK cascade regulation of localization protein localization to synapse regulation of protein localization regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels regulation of cellular localization protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse response to mechanical stimulus response to external stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus basement membrane assembly involved in embryonic body morphogenesis positive regulation of cellular component organization cellular component assembly involved in morphogenesis positive regulation of extracellular matrix organization body morphogenesis cellular component biogenesis positive regulation of developmental process cellular anatomical entity morphogenesis cellular component assembly regulation of extracellular matrix assembly regulation of basement membrane organization extracellular matrix assembly positive regulation of basement membrane assembly involved in embryonic body morphogenesis positive regulation of cellular component biogenesis regulation of basement membrane assembly involved in embryonic body morphogenesis embryonic body morphogenesis regulation of cellular component biogenesis positive regulation of extracellular matrix assembly basement membrane assembly regulation of extracellular matrix organization trans-synaptic signaling trans-synaptic signaling by trans-synaptic complex retrograde trans-synaptic signaling cell-cell signaling retrograde trans-synaptic signaling by trans-synaptic protein complex synaptic signaling regulation of synaptic plasticity modulation of chemical synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regeneration response to axon injury neuron projection regeneration axon regeneration cellular response to stress tissue regeneration skeletal muscle tissue regeneration developmental growth growth positive regulation of nervous system development regulation of neurogenesis regulation of gliogenesis positive regulation of gliogenesis regulation of cell development positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of oligodendrocyte differentiation regulation of glial cell differentiation positive regulation of cell development positive regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation regulation of oligodendrocyte differentiation gland development branching involved in salivary gland morphogenesis salivary gland development gland morphogenesis salivary gland morphogenesis exocrine system development proteolysis membrane protein proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process membrane protein ectodomain proteolysis	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell surface external side of plasma membrane side of membrane basement membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol sarcolemma intracellular membraneless organelle intracellular organelle costamere membraneless organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex basal part of cell basal plasma membrane basolateral plasma membrane glutamatergic synapse cell-cell junction adherens junction anchoring junction cytoskeleton membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum glycoprotein complex protein-containing complex plasma membrane protein complex dystroglycan complex membrane protein complex dystrophin-associated glycoprotein complex actin-based cell projection filopodium focal adhesion cell-substrate junction axon main axon neuron projection node of Ranvier nucleus nuclear periphery nuclear lumen nucleoplasm GABA-ergic synapse Golgi apparatus Golgi lumen photoreceptor ribbon synapse ribbon synapse membrane microdomain membrane raft plasma membrane raft contractile ring cytosolic region postsynaptic cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR039477	ILEI/PANDER domain	Domain
A, B	IPR004139	Glycosyl transferase, family 13	Family
A, B	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A, B	IPR039474	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1, PANDER-like domain	Domain
A, B	IPR052463	O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase	Family
C, D	IPR015919	Cadherin-like superfamily	Homologous Superfamily
C, D	IPR006644	Dystroglycan-type cadherin-like	Domain
C, D	IPR008465	Dystroglycan, C-terminal	Domain
C, D	IPR027468	Alpha-dystroglycan domain 2	Homologous Superfamily
C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C, D	IPR041631	Alpha-dystroglycan N-terminal domain 2	Domain
C, D	IPR030398	DG-type SEA domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8WZA1	autosomal recessive limb-girdle muscular dystrophy type 2O limb-girdle muscular dystrophy retinitis pigmentosa muscular dystrophy-dystroglycanopathy, type A muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3 congenital muscular dystrophy muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B3 retinitis pigmentosa 76 lissencephaly spectrum disorders malignant glioma muscle tissue disease muscular dystrophy alpha-Dystroglycanopathies retinal degeneration cerebrovascular disorder autosomal recessive limb-girdle muscular dystrophy type 2O limb-girdle muscular dystrophy retinitis pigmentosa muscular dystrophy-dystroglycanopathy, type A muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3 congenital muscular dystrophy muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B3 retinitis pigmentosa 76 lissencephaly spectrum disorders malignant glioma muscle tissue disease muscular dystrophy alpha-Dystroglycanopathies retinal degeneration cerebrovascular disorder hydrocephalus medulloblastoma muscle-eye-brain disease muscular dystrophy-dystroglycanopathy arthrogryposis myopathy cataract cone-rod dystrophy intellectual disability malignant ependymoma muscular disease muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 atypical teratoid rhabdoid tumor osteosarcoma congenital disorder of glycosylation glioblastoma large cell medulloblastoma lung carcinoma
C, D	Pharos: Q14118	limb-girdle muscular dystrophy autosomal recessive limb-girdle muscular dystrophy type 2P muscular dystrophy-dystroglycanopathy, type A muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A9 Lassa fever myopathy lissencephaly spectrum disorders prostate cancer congenital muscular dystrophy muscle tissue disease muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2K osteoporosis prostate carcinoma atypical teratoid rhabdoid tumor limb-girdle muscular dystrophy autosomal recessive limb-girdle muscular dystrophy type 2P muscular dystrophy-dystroglycanopathy, type A muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A9 Lassa fever myopathy lissencephaly spectrum disorders prostate cancer congenital muscular dystrophy muscle tissue disease muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2K osteoporosis prostate carcinoma atypical teratoid rhabdoid tumor endogenous depression hydrocephalus muscular disease ovarian cancer arthrogryposis common variable immunodeficiency endometriosis intellectual disability muscular dystrophy oligodendroglioma psoriasis astrocytic tumor cataract heart disease lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.