5HY4

Structure-function analysis of functionally diverse members of the cyclic amide hydrolase family of Toblerone fold enzymes

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5hy4b_	Alpha and beta proteins (a+b)	Bacillus chorismate mutase-like	YjgF-like	automated matches	automated matches	(Frankia sp. Eul1b ) [TaxId: 985774 ],	SCOPe (2.08)
H	d5hy4h_	Alpha and beta proteins (a+b)	Bacillus chorismate mutase-like	YjgF-like	automated matches	automated matches	(Frankia sp. Eul1b ) [TaxId: 985774 ],	SCOPe (2.08)
A	d5hy4a_	Alpha and beta proteins (a+b)	Bacillus chorismate mutase-like	YjgF-like	automated matches	automated matches	(Frankia sp. Eul1b ) [TaxId: 985774 ],	SCOPe (2.08)
C	d5hy4c_	Alpha and beta proteins (a+b)	Bacillus chorismate mutase-like	YjgF-like	automated matches	automated matches	(Frankia sp. Eul1b ) [TaxId: 985774 ],	SCOPe (2.08)
D	d5hy4d_	Alpha and beta proteins (a+b)	Bacillus chorismate mutase-like	YjgF-like	automated matches	automated matches	(Frankia sp. Eul1b ) [TaxId: 985774 ],	SCOPe (2.08)
E	d5hy4e_	Alpha and beta proteins (a+b)	Bacillus chorismate mutase-like	YjgF-like	automated matches	automated matches	(Frankia sp. Eul1b ) [TaxId: 985774 ],	SCOPe (2.08)
F	d5hy4f_	Alpha and beta proteins (a+b)	Bacillus chorismate mutase-like	YjgF-like	automated matches	automated matches	(Frankia sp. Eul1b ) [TaxId: 985774 ],	SCOPe (2.08)
G	d5hy4g_	Alpha and beta proteins (a+b)	Bacillus chorismate mutase-like	YjgF-like	automated matches	automated matches	(Frankia sp. Eul1b ) [TaxId: 985774 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	YjgF-like	8090345	3001733	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	YjgF-like	8090344	3001733	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	YjgF-like	8090343	3001733	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	YjgF-like	8090345	3001733	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	YjgF-like	8090343	3001733	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	YjgF-like	8090344	3001733	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	YjgF-like	8090345	3001733	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	YjgF-like	8090343	3001733	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	YjgF-like	8090343	3001733	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	YjgF-like	8090344	3001733	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	YjgF-like	8090345	3001733	SCOP2B (2022-06-29)
D	SCOP2 Family	AtzD-like	8060231	4004437	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	YjgF-like	8090344	3001733	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	YjgF-like	8090343	3001733	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	YjgF-like	8090345	3001733	SCOP2 (2022-06-29)
E	SCOP2B Superfamily	YjgF-like	8090344	3001733	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	YjgF-like	8090343	3001733	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	YjgF-like	8090345	3001733	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	YjgF-like	8090345	3001733	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	YjgF-like	8090344	3001733	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	YjgF-like	8090343	3001733	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	YjgF-like	8090345	3001733	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	YjgF-like	8090343	3001733	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	YjgF-like	8090344	3001733	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Amido_AtzD_TrzD_1st	e5hy4B3	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_1st	ECOD (1.6)
B	Amido_AtzD_TrzD_2nd	e5hy4B2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_2nd	ECOD (1.6)
B	Amido_AtzD_TrzD_3rd	e5hy4B1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_3rd	ECOD (1.6)
H	Amido_AtzD_TrzD_1st	e5hy4H3	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_1st	ECOD (1.6)
H	Amido_AtzD_TrzD_2nd	e5hy4H2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_2nd	ECOD (1.6)
H	Amido_AtzD_TrzD_3rd	e5hy4H1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_3rd	ECOD (1.6)
A	Amido_AtzD_TrzD_1st	e5hy4A1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_1st	ECOD (1.6)
A	Amido_AtzD_TrzD_2nd	e5hy4A2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_2nd	ECOD (1.6)
A	Amido_AtzD_TrzD_3rd	e5hy4A3	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_3rd	ECOD (1.6)
C	Amido_AtzD_TrzD_1st	e5hy4C1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_1st	ECOD (1.6)
C	Amido_AtzD_TrzD_2nd	e5hy4C2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_2nd	ECOD (1.6)
C	Amido_AtzD_TrzD_3rd	e5hy4C3	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_3rd	ECOD (1.6)
D	Amido_AtzD_TrzD_1st	e5hy4D1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_1st	ECOD (1.6)
D	Amido_AtzD_TrzD_2nd	e5hy4D3	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_2nd	ECOD (1.6)
D	Amido_AtzD_TrzD_3rd	e5hy4D2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_3rd	ECOD (1.6)
E	Amido_AtzD_TrzD_1st	e5hy4E1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_1st	ECOD (1.6)
E	Amido_AtzD_TrzD_2nd	e5hy4E3	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_2nd	ECOD (1.6)
E	Amido_AtzD_TrzD_3rd	e5hy4E2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_3rd	ECOD (1.6)
F	Amido_AtzD_TrzD_1st	e5hy4F2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_1st	ECOD (1.6)
F	Amido_AtzD_TrzD_2nd	e5hy4F3	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_2nd	ECOD (1.6)
F	Amido_AtzD_TrzD_3rd	e5hy4F1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_3rd	ECOD (1.6)
G	Amido_AtzD_TrzD_1st	e5hy4G1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_1st	ECOD (1.6)
G	Amido_AtzD_TrzD_2nd	e5hy4G2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_2nd	ECOD (1.6)
G	Amido_AtzD_TrzD_3rd	e5hy4G3	A: a+b three layers	X: Bacillus chorismate mutase-like	H: YjgF-like (From Topology)	T: YjgF-like	F: Amido_AtzD_TrzD_3rd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.1330.170	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
B	3.30.1330.160	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
H	3.30.1330.170	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
H	3.30.1330.160	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
A	3.30.1330.170	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
A	3.30.1330.160	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
C	3.30.1330.170	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
C	3.30.1330.160	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
D	3.30.1330.170	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
D	3.30.1330.160	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
E	3.30.1330.170	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
E	3.30.1330.160	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
F	3.30.1330.170	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
F	3.30.1330.160	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
G	3.30.1330.170	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
G	3.30.1330.180	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
G	3.30.1330.160	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF09663	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) (Amido_AtzD_TrzD)	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Ring-opening amidohydrolase	hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR043006	Cyanuric acid hydrolase/Barbiturase, repeating unit B	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR043007	Cyanuric acid hydrolase/Barbiturase, repeating unit C	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR014086	Cyanuric acid hydrolase/Barbiturase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR043008	Cyanuric acid hydrolase/Barbiturase, repeating unit A	Homologous Superfamily