Annotations: 5IRL

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LRR_8_4	e5irlA5	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_4	ECOD (1.6)
A	EUF07896	e5irlA4	A: alpha arrays	X: HTH	H: HTH	T: winged	F: EUF07896	ECOD (1.6)
A	EUF07952	e5irlA1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: EUF07952	ECOD (1.6)
A	EUF08242	e5irlA3	A: alpha superhelices	X: NLRC4 helical domain HD2 (From Topology)	H: NLRC4 helical domain HD2 (From Topology)	T: NLRC4 helical domain HD2	F: EUF08242	ECOD (1.6)
A	NACHT	e5irlA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: NACHT	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
A	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05729	NACHT domain (NACHT)	NACHT domain	This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation [1]. This family is closely related to Pfam:PF00931.	Domain
A	PF13516	Leucine Rich repeat (LRR_6)	Leucine Rich repeat	-	Repeat
A	PF17776	NLRC4 helical domain HD2 (NLRC4_HD2)	NLRC4 helical domain HD2	This entry represents a helical domain found in the NLRC4 protein [2] and NOD2 protein [1].	Domain
A	PF17779	NOD2 winged helix domain (WHD_NOD2)	NOD2 winged helix domain	This winged helix domain is found in the NOD2 protein [1]. Its molecular function is not known.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Uncharacterized protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ADP binding protein-containing complex binding muramyl dipeptide binding amide binding organic acid binding carboxylic acid binding monocarboxylic acid binding Hsp90 protein binding protein binding heat shock protein binding glycosaminoglycan binding peptidoglycan binding Hsp70 protein binding protein-folding chaperone binding ubiquitin binding ubiquitin-like protein binding molecular transducer activity pattern recognition receptor activity signaling receptor activity kinase binding enzyme binding protein kinase binding cytoskeletal protein binding actin binding CARD domain binding protein domain specific binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of cellular response to stress positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus stress-activated MAPK cascade cellular response to stress regulation of intracellular signal transduction cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of cellular response to stress positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus stress-activated MAPK cascade cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress intracellular signaling cassette signal transduction positive regulation of stress-activated protein kinase signaling cascade positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of stress-activated MAPK cascade positive regulation of MAPK cascade biological regulation regulation of stress-activated protein kinase signaling cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade regulation of response to stimulus MAPK cascade regulation of cell communication cellular process positive regulation of signaling immune response immune system process adaptive immune response catabolic process autophagy metabolic process process utilizing autophagic mechanism biological process involved in interspecies interaction between organisms detection of external biotic stimulus response to other organism response to external stimulus detection of biotic stimulus detection of bacterium response to biotic stimulus detection of stimulus response to bacterium detection of other organism response to external biotic stimulus regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death multicellular organismal process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells intestinal stem cell homeostasis defense response to bacterium defense response interleukin-1 production regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of interleukin-1 beta production positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-1 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway regulation of innate immune response defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus intracellular receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway innate immune response nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway positive regulation of innate immune response defense response to symbiont positive regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production positive regulation of JNK cascade JNK cascade regulation of JNK cascade host-mediated modulation of intestinal microbiota composition modulation of process of another organism host-mediated perturbation of symbiont process regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell activation positive regulation of leukocyte activation B cell activation cell activation positive regulation of B cell activation regulation of lymphocyte activation regulation of protein modification process positive regulation of protein metabolic process regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process protein K63-linked ubiquitination regulation of protein K63-linked ubiquitination positive regulation of protein modification process protein ubiquitination protein metabolic process protein modification process regulation of protein modification by small protein conjugation or removal positive regulation of protein K63-linked ubiquitination positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of protein polyubiquitination regulation of post-translational protein modification regulation of protein metabolic process protein polyubiquitination primary metabolic process positive regulation of protein polyubiquitination macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal detection of peptidoglycan response to oxygen-containing compound response to muramyl dipeptide response to nitrogen compound detection of molecule of bacterial origin response to chemical detection of chemical stimulus detection of muramyl dipeptide response to molecule of bacterial origin response to peptidoglycan positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription maintenance of gastrointestinal epithelium system process digestion epithelial structure maintenance digestive system process anatomical structure homeostasis tissue homeostasis positive regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production response to lipid cellular response to lipopolysaccharide cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus cellular response to lipid positive regulation of type 2 immune response type 2 immune response regulation of type 2 immune response cellular response to nitrogen compound cellular response to muramyl dipeptide regulation of inflammatory response inflammatory response regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production response to nutrient levels regulation of biological quality regulation of appetite temperature homeostasis regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response macroautophagy regulation of autophagy positive regulation of autophagy of mitochondrion mitophagy regulation of autophagy of mitochondrion positive regulation of macroautophagy positive regulation of autophagy positive regulation of mitophagy regulation of mitophagy regulation of catabolic process positive regulation of catabolic process regulation of macroautophagy autophagy of mitochondrion regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of immune effector process positive regulation of immune effector process cytokine production involved in immune response production of molecular mediator of immune response regulation of cytokine production involved in immune response immune effector process positive regulation of cytokine production involved in immune response positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response antibacterial innate immune response	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane membrane-bounded organelle intracellular organelle Golgi apparatus cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system cytoskeleton membraneless organelle intracellular membraneless organelle extrinsic component of plasma membrane extrinsic component of membrane mitochondrion cell surface intracellular vesicle phagocytic vesicle cytoplasmic vesicle vesicle endocytic vesicle protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR051261	NOD-like receptor	Family
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR007111	NACHT nucleoside triphosphatase	Domain
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR041267	NACHT, LRR and PYD domains-containing protein, helical domain HD2	Domain
A	IPR041075	NOD1/2, winged helix domain	Domain
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR001315	CARD domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.