5KN5 | pdb_00005kn5

TGFalpha/Epiregulin complex with neutralizing antibody LY3016859

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Thera-SAbDab Antibody Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	V-set_8	e5kn5A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
A	C1-set_1	e5kn5A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
D	V-set_8	e5kn5D2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
D	C1-set_1	e5kn5D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
B	C1-set_4	e5kn5B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
B	V-set	e5kn5B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
E	C1-set_4	e5kn5E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
E	V-set	e5kn5E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
C	EGF_1	e5kn5C1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: EGF_1	ECOD (1.6)
F	EGF_1	e5kn5F1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: EGF_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, D	LY3016859 Fab	VH-CH1	Homo sapiens (human)	IGHV1-6902, IGHV1-6904, IGHV1-6909, IGHV1-6910, IGHJ601, IGHJ602, IGHG401, IGHG404	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-4_KAPPA	IMGT (202512-0)
B, E	LY3016859 Fab	L-KAPPA	Homo sapiens (human)	IGKV4-101, IGKJ401, IGKJ402, IGKC01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-4_KAPPA	IMGT (202512-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A, D	Heavy Chain	IGHV1	-	protransforming growth factor alpha	SAbDab (2025-04-04)
B, E	Light Chain	IGKV4	Kappa	protransforming growth factor alpha	SAbDab (2025-04-04)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

Chain	Name	Target	Provenance Source
A, D	Fepixnebart	EREG	Therapeutic SAbDab (2025-04-04)
B, E	Fepixnebart	EREG	Therapeutic SAbDab (2025-04-04)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Epiregulin Antibody LY3016859 Fab Heavy Chain	-	-	-
B, E	Epiregulin Antibody LY3016859 Fab Light Chain	-	-	-
C, F	Protransforming growth factor alpha	molecular transducer activity protein binding binding molecular function activator activity signaling receptor binding signaling receptor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity growth factor activity protein tyrosine kinase activator activity enzyme regulator activity transmembrane receptor protein tyrosine kinase activator activity molecular transducer activity protein binding binding molecular function activator activity signaling receptor binding signaling receptor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity growth factor activity protein tyrosine kinase activator activity enzyme regulator activity transmembrane receptor protein tyrosine kinase activator activity catalytic activity, acting on a protein transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity kinase regulator activity kinase activity protein kinase activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor kinase activator activity enzyme activator activity protein kinase activator activity epidermal growth factor receptor binding growth factor receptor binding	developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation positive regulation of epithelial cell proliferation biological regulation positive regulation of biological process regulation of cell population proliferation cellular process regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of cellular process positive regulation of cell division cell division regulation of cell division positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division gland development animal organ development epithelial cell proliferation involved in liver morphogenesis liver development gland morphogenesis hepatocyte proliferation hepaticobiliary system development animal organ morphogenesis liver morphogenesis cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication ERBB signaling pathway epidermal growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication positive regulation of signaling ERBB2 signaling pathway ERBB2-EGFR signaling pathway mammary gland development mammary gland lobule development mammary gland alveolus development regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of peptidyl-tyrosine phosphorylation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process peptidyl-tyrosine phosphorylation regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane cell surface cell periphery plasma membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane extracellular region endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment perinuclear region of cytoplasm extracellular space transport vesicle transport vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, F	IPR000742	EGF-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, F	Pharos: P01135	psoriasis non-small cell lung carcinoma hepatoblastoma Inflammation pulmonary hypertension head and neck cancer papilloma prostate cancer liver cancer pulmonary edema pulmonary fibrosis squamous papilloma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma interstitial cystitis psoriasis non-small cell lung carcinoma hepatoblastoma Inflammation pulmonary hypertension head and neck cancer papilloma prostate cancer liver cancer pulmonary edema pulmonary fibrosis squamous papilloma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma interstitial cystitis liver neoplasm malignant pancreatic neoplasm subependymal giant cell astrocytoma exocrine pancreatic carcinoma mammary neoplasms, animal ulcerative colitis gastric neoplasm neoplasm of neck ovarian cancer astrocytic tumor malignant ependymoma spina bifida malignant tumor of neck tooth agenesis gastrointestinal mucositis nephrosclerosis head and neck neoplasm hepatocellular carcinoma osteoarthritis hereditary diffuse gastric adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm idiopathic interstitial pneumonia papillomatosis inherited disease susceptibility lung cancer pustulosis palmaris et plantaris breast cancer Down syndrome tuberculosis gastric cancer medulloblastoma nonsyndromic genetic deafness osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.