5NUP | pdb_00005nup

Structural basis for maintenance of bacterial outer membrane lipid asymmetry

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d5nupc_	Membrane and cell surface proteins and peptides	Transmembrane beta-barrels	Porins	Porin	automated matches	(Klebsiella pneumoniae ) [TaxId: 573 ],	SCOPe (2.08)
B	d5nupb_	Membrane and cell surface proteins and peptides	Transmembrane beta-barrels	Porins	Porin	automated matches	(Klebsiella pneumoniae ) [TaxId: 573 ],	SCOPe (2.08)
A	d5nupa_	Membrane and cell surface proteins and peptides	Transmembrane beta-barrels	Porins	Porin	automated matches	(Klebsiella pneumoniae ) [TaxId: 573 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Porins	8097754	3000224	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Porins	8097754	3000224	SCOP2B (2022-06-29)
A	SCOP2 Family	Porin	8097753	4003061	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Porins	8097754	3000224	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	UNK_F_TYPE	e5nupD1	A: alpha arrays	X: Phospholipid translocation channel MlaA (From Topology)	H: Phospholipid translocation channel MlaA (From Topology)	T: Phospholipid translocation channel MlaA	F: UNK_F_TYPE	ECOD (1.6)
E	UNK_F_TYPE	e5nupE1	A: alpha arrays	X: Phospholipid translocation channel MlaA (From Topology)	H: Phospholipid translocation channel MlaA (From Topology)	T: Phospholipid translocation channel MlaA	F: UNK_F_TYPE	ECOD (1.6)
F	UNK_F_TYPE	e5nupF1	A: alpha arrays	X: Phospholipid translocation channel MlaA (From Topology)	H: Phospholipid translocation channel MlaA (From Topology)	T: Phospholipid translocation channel MlaA	F: UNK_F_TYPE	ECOD (1.6)
C	Porin_1	e5nupC1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Porin	F: Porin_1	ECOD (1.6)
B	Porin_1	e5nupB1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Porin	F: Porin_1	ECOD (1.6)
A	Porin_1	e5nupA1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Porin	F: Porin_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.40.160.10	Mainly Beta	Beta Barrel	Porin	Porin	CATH (4.3.0)
B	2.40.160.10	Mainly Beta	Beta Barrel	Porin	Porin	CATH (4.3.0)
A	2.40.160.10	Mainly Beta	Beta Barrel	Porin	Porin	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
D, E, F	ABC transporter permease	-	membrane organization intermembrane lipid transfer transport lipid localization phospholipid transport lipid transport establishment of localization cellular component organization localization intermembrane phospholipid transfer macromolecule localization cellular process cellular component organization or biogenesis organophosphate ester transport	cellular anatomical structure membrane
A, B, C	OmpK36	wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity	transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport cellular process establishment of localization	protein-containing complex cellular anatomical structure membrane pore complex membrane protein complex cell periphery cell outer membrane external encapsulating structure cell envelope outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D, E, F	IPR007428	MlaA lipoprotein	Family
A, B, C	IPR050298	Gram-negative bacterial outer membrane porin	Family
A, B, C	IPR023614	Porin domain superfamily	Homologous Superfamily
A, B, C	IPR001702	Porin, Gram-negative type	Family
A, B, C	IPR013793	Porin, Gram-negative type, conserved site	Conserved Site
A, B, C	IPR001897	Porin, gammaproteobacterial	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Transmembrane	Beta-barrel transmembrane	Trimeric porins (n=16,S=20)	General Bacterial Porin (GBP)

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Outer Membrane Proteins	MlaA lipid transport protein in complex with OmpF

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.