Annotations: 6AR0

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FHA	e6ar0A1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00498	FHA domain (FHA)	FHA domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sarcolemmal membrane-associated protein	protein-macromolecule adaptor activity molecular adaptor activity	regulation of localization regulation of cellular process transport monoatomic ion transmembrane transport sodium ion transmembrane transport regulation of monoatomic ion transmembrane transport regulation of sodium ion transport regulation of sodium ion transmembrane transport metal ion transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of localization regulation of cellular process transport monoatomic ion transmembrane transport sodium ion transmembrane transport regulation of monoatomic ion transmembrane transport regulation of sodium ion transport regulation of sodium ion transmembrane transport metal ion transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport cellular process regulation of monoatomic cation transmembrane transport sodium ion transport regulation of transmembrane transporter activity regulation of transporter activity regulation of sodium ion transmembrane transporter activity regulation of voltage-gated sodium channel activity regulation of monoatomic ion transmembrane transporter activity regulation of cation channel activity regulation of molecular function cellular response to stimulus hippo signaling response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction negative regulation of cellular process signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of hippo signaling multicellular organismal process system process muscle contraction muscle system process regulation of membrane depolarization during cardiac muscle cell action potential membrane depolarization during action potential membrane depolarization during cardiac muscle cell action potential action potential regulation of membrane depolarization membrane depolarization regulation of biological quality cardiac muscle cell action potential regulation of membrane potential regulation of membrane depolarization during action potential protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane	M band intracellular anatomical structure intracellular membraneless organelle sarcomere intracellular organelle cellular anatomical structure organelle membraneless organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer M band intracellular anatomical structure intracellular membraneless organelle sarcomere intracellular organelle cellular anatomical structure organelle membraneless organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex Z disc I band centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton membrane-bounded organelle mitochondrial membrane mitochondrion membrane intracellular membrane-bounded organelle organelle envelope mitochondrial envelope organelle membrane cell periphery sarcolemma plasma membrane endoplasmic reticulum smooth endoplasmic reticulum endomembrane system FAR/SIN/STRIPAK complex protein-containing complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A	IPR000253	Forkhead-associated (FHA) domain	Domain
A	IPR051176	Centrosomal and Immune Signaling Modulators	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14BN4	Brugada syndrome adenoma hereditary spastic paraplegia malignant pancreatic neoplasm ovarian cancer primitive neuroectodermal tumor tuberculosis atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease hypertrophic pyloric stenosis medulloblastoma pancreatic ductal adenocarcinoma rheumatoid arthritis breast cancer glioblastoma Brugada syndrome adenoma hereditary spastic paraplegia malignant pancreatic neoplasm ovarian cancer primitive neuroectodermal tumor tuberculosis atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease hypertrophic pyloric stenosis medulloblastoma pancreatic ductal adenocarcinoma rheumatoid arthritis breast cancer glioblastoma large cell medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm spina bifida

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.