6B7H | pdb_00006b7h

Structure of mGluR3 with an agonist

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6b7ha1	Alpha and beta proteins (a/b)	Periplasmic binding protein-like I	Periplasmic binding protein-like I	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d6b7ha2	Artifacts	Tags	Tags	Tags	C-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Type 1 solute binding protein-like	8078801	3000125	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ANF_receptor_2nd_1	e6b7hA2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01094	Receptor family ligand binding region (ANF_receptor)	Receptor family ligand binding region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Metabotropic glutamate receptor 3	molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity glutamate receptor activity scaffold protein binding protein binding binding calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity calcium channel regulator activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity glutamate receptor activity scaffold protein binding protein binding binding calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity calcium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transporter regulator activity transmembrane transporter activity group II metabotropic glutamate receptor activity G protein-coupled glutamate receptor activity adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	regulation of molecular function negative regulation of lyase activity regulation of adenylate cyclase activity regulation of catalytic activity biological regulation negative regulation of molecular function negative regulation of catalytic activity negative regulation of adenylate cyclase activity cellular response to stimulus cellular response to stress response to stimulus response to stress cellular process trans-synaptic signaling regulation of molecular function negative regulation of lyase activity regulation of adenylate cyclase activity regulation of catalytic activity biological regulation negative regulation of molecular function negative regulation of catalytic activity negative regulation of adenylate cyclase activity cellular response to stimulus cellular response to stress response to stimulus response to stress cellular process trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling postsynaptic modulation of chemical synaptic transmission regulation of cell communication biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process cell surface receptor signaling pathway glutamate receptor signaling pathway G protein-coupled glutamate receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane glial cell projection cell projection plasma membrane bounded cell projection astrocyte projection cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane glial cell projection cell projection plasma membrane bounded cell projection astrocyte projection presynapse presynaptic membrane glutamatergic synapse neuron spine neuron projection dendritic spine somatodendritic compartment dendrite dendritic tree postsynaptic density neuron to neuron synapse postsynaptic specialization organelle asymmetric synapse axon

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017978	GPCR family 3, C-terminal	Domain
A	IPR017979	GPCR, family 3, conserved site	Conserved Site
A	IPR000337	GPCR, family 3	Family
A	IPR038550	GPCR, family 3, nine cysteines domain superfamily	Homologous Superfamily
A	IPR001234	GPCR, family 3, metabotropic glutamate receptor 3	Family
A	IPR011500	GPCR, family 3, nine cysteines domain	Domain
A	IPR028082	Periplasmic binding protein-like I	Homologous Superfamily
A	IPR000162	GPCR, family 3, metabotropic glutamate receptor	Family
A	IPR001828	Receptor, ligand binding region	Domain
A	IPR050726	Metabotropic Glutamate Receptor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14832	schizophrenia melanoma temporal lobe epilepsy bipolar disorder ovarian cancer psoriasis Addicted to cocaine attention deficit hyperactivity disorder, inattentive type lung carcinoma medulloblastoma oligodendroglioma pilocytic astrocytoma atypical teratoid rhabdoid tumor cutaneous melanoma glioblastoma schizophrenia melanoma temporal lobe epilepsy bipolar disorder ovarian cancer psoriasis Addicted to cocaine attention deficit hyperactivity disorder, inattentive type lung carcinoma medulloblastoma oligodendroglioma pilocytic astrocytoma atypical teratoid rhabdoid tumor cutaneous melanoma glioblastoma malignant ependymoma osteosarcoma primitive neuroectodermal tumor subependymal giant cell astrocytoma astrocytic tumor autism spectrum disorder large cell medulloblastoma malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.