6H8K | pdb_00006h8k

Crystal structure of a variant (Q133C in PSST) of Yarrowia lipolytica complex I

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
I [auth C]	SCOP2 Family	Nqo4-like	8085738	4000433	SCOP2 (2022-06-29)
I [auth C]	SCOP2 Superfamily	HydB/Nqo4-like	8085739	3001849	SCOP2 (2022-06-29)
F [auth 6]	SCOP2B Superfamily	NADH-quinone oxidoreductase, subunit 11-like	8053517	3002200	SCOP2B (2022-06-29)
D [auth 4]	SCOP2B Superfamily	Antiporter subunits half-channel-like	8071762	3002280	SCOP2B (2022-06-29)
D [auth 4]	SCOP2B Superfamily	Antiporter subunits half-channel-like	8093347	3002280	SCOP2B (2022-06-29)
C [auth 3]	SCOP2 Family	NADH-ubiquinone oxidoreductase chain 3-like	8085719	4005842	SCOP2 (2022-06-29)
C [auth 3]	SCOP2 Superfamily	NADH-quinone oxidoreductase, subunit 11-like	8106708	3002200	SCOP2 (2022-06-29)
O [auth L]	SCOP2B Superfamily	NADH-quinone oxidoreductase, subunit 11-like	8053510	3002200	SCOP2B (2022-06-29)
N [auth K]	SCOP2 Family	Nq06/HydA N-terminal domain-like	8085724	4007641	SCOP2 (2022-06-29)
N [auth K]	SCOP2 Superfamily	Nqo6/HydA N-terminal domain-like	8085725	3002291	SCOP2 (2022-06-29)
A [auth 1]	SCOP2 Family	NADH-quinone oxidoreductase subunit 8-like	8067552	4005664	SCOP2 (2022-06-29)
A [auth 1]	SCOP2 Superfamily	Antiporter subunits half-channel-like	8067553	3002280	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
I [auth C]	Complex1_49kDa_1st	e6h8kC2	A: alpha complex topology	X: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	H: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	T: alpha-helical domain in nickel-iron hydrogenase, large subunit	F: Complex1_49kDa_1st	ECOD (1.6)
I [auth C]	NuoD	e6h8kC3	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: NuoD	ECOD (1.6)
I [auth C]	Complex1_49kDa_2nd	e6h8kC1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: Complex1_49kDa_2nd	ECOD (1.6)
H [auth B]	NADH_4Fe-4S	e6h8kB1	A: alpha bundles	X: Bromodomain-like	H: Nqo1C-terminal domain-like (From Topology)	T: Nqo1C-terminal domain-like	F: NADH_4Fe-4S	ECOD (1.6)
H [auth B]	F_UNCLASSIFIED	e6h8kB3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Nqo1 middle domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth B]	Complex1_51K	e6h8kB2	A: a/b three-layered sandwiches	X: Nqo1 FMN-binding domain-like (From Topology)	H: Nqo1 FMN-binding domain-like (From Topology)	T: Nqo1 FMN-binding domain-like	F: Complex1_51K	ECOD (1.6)
G [auth A]	F_UNCLASSIFIED	e6h8kA6	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth A]	PRK09129	e6h8kA3	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PRK09129	ECOD (1.6)
G [auth A]	Fer2_4	e6h8kA2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_4	ECOD (1.6)
G [auth A]	F_UNCLASSIFIED	e6h8kA7	A: a+b two layers	X: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	H: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domain 1	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth A]	F_UNCLASSIFIED	e6h8kA4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth A]	NADH-G_4Fe-4S_3	e6h8kA1	A: extended segments	X: iron-sulfur center-binding helical hairpin (From Topology)	H: iron-sulfur center-binding helical hairpin (From Topology)	T: iron-sulfur center-binding helical hairpin	F: NADH-G_4Fe-4S_3	ECOD (1.6)
F [auth 6]	Oxidored_q3	e6h8k61	A: extended segments	X: NADH-quinone oxidoreductase subunit J (From Topology)	H: NADH-quinone oxidoreductase subunit J (From Topology)	T: NADH-quinone oxidoreductase subunit J	F: Oxidored_q3	ECOD (1.6)
E [auth 5]	Proton_antipo_M	e6h8k51	A: alpha complex topology	X: Sodium/proton antiporter subunits-like (From Homology)	H: Sodium/proton antiporter subunits-like	T: NADH-quinone oxidoreductase subunit L (NuoL)-related	F: Proton_antipo_M	ECOD (1.6)
D [auth 4]	Proton_antipo_M	e6h8k41	A: alpha complex topology	X: Sodium/proton antiporter subunits-like (From Homology)	H: Sodium/proton antiporter subunits-like	T: NADH-quinone oxidoreductase subunit L (NuoL)-related	F: Proton_antipo_M	ECOD (1.6)
C [auth 3]	Oxidored_q4	e6h8k31	A: extended segments	X: NADH-quinone oxidoreductase subunit A (From Topology)	H: NADH-quinone oxidoreductase subunit A (From Topology)	T: NADH-quinone oxidoreductase subunit A	F: Oxidored_q4	ECOD (1.6)
B [auth 2]	Proton_antipo_M	e6h8k21	A: alpha complex topology	X: Sodium/proton antiporter subunits-like (From Homology)	H: Sodium/proton antiporter subunits-like	T: NADH-quinone oxidoreductase subunit L (NuoL)-related	F: Proton_antipo_M	ECOD (1.6)
O [auth L]	Oxidored_q2	e6h8kL1	A: alpha complex topology	X: NADH-quinone oxidoreductase subunit K (From Topology)	H: NADH-quinone oxidoreductase subunit K (From Topology)	T: NADH-quinone oxidoreductase subunit K	F: Oxidored_q2	ECOD (1.6)
N [auth K]	Oxidored_q6	e6h8kK1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: Oxidored_q6	ECOD (1.6)
M [auth I]	Fer4_21_1	e6h8kI1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: Fer4_21_1	ECOD (1.6)
K [auth G]	Complex1_30kDa	e6h8kG1	A: a+b two layers	X: Nqo5-like	H: Nqo5-like (From Topology)	T: Nqo5-like	F: Complex1_30kDa	ECOD (1.6)
A [auth 1]	NADHdh	e6h8k11	A: alpha complex topology	X: Sodium/proton antiporter subunits-like (From Homology)	H: Sodium/proton antiporter subunits-like	T: NADH-quinone oxidoreductase subunit 8 (Nqo8)-related	F: NADHdh	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
I [auth C]	PF00346	Respiratory-chain NADH dehydrogenase, 49 Kd subunit (Complex1_49kDa)	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	Family
H [auth B]	PF22461	SLBB domain (SLBB_2)	SLBB domain	This entry represents a set of SLBB domains [5].	Domain
H [auth B]	PF01512	Nuo51 FMN-binding domain (Complex1_51K)	Nuo51 FMN-binding domain	This entry represents the FMN-binding domain of NADH-ubiquinone oxidoreductase 51kDa subunit from NADH:ubiquinone oxidoreductase.	Domain
H [auth B]	PF10589	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region (NADH_4Fe-4S)	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region		Domain
G [auth A]	PF22117	NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain (Fer4_Nqo3)	NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain	NADH-quinone oxidoreductase subunit 3 (Nqo3) is a component of respiratory complex I. This protein is located at the peripheral arm of the complex and consists of multiple domains. This entry represents the second ferredoxin-like domain which contain ...	NADH-quinone oxidoreductase subunit 3 (Nqo3) is a component of respiratory complex I. This protein is located at the peripheral arm of the complex and consists of multiple domains. This entry represents the second ferredoxin-like domain which contains Fe4-S4 cluster, one of the redox centers of the complex [1-5].	Domain
G [auth A]	PF13510	2Fe-2S iron-sulfur cluster binding domain (Fer2_4)	2Fe-2S iron-sulfur cluster binding domain	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. Th ...	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.	Domain
G [auth A]	PF10588	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region (NADH-G_4Fe-4S_3)	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region		Domain
F [auth 6]	PF00499	NADH-ubiquinone/plastoquinone oxidoreductase chain 6 (Oxidored_q3)	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	Family
E [auth 5]	PF00361	NADH:quinone oxidoreductase/Mrp antiporter, TM (Proton_antipo_M)	NADH:quinone oxidoreductase/Mrp antiporter, TM	This entry includes membrane transporters and represents some 7 of potentially 14-16 TM regions. In many instances, its members forms part of complex I that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associa ...	This entry includes membrane transporters and represents some 7 of potentially 14-16 TM regions. In many instances, its members forms part of complex I that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N [1]. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction [2].	Domain
E [auth 5]	PF00662	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus (Proton_antipo_N)	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	This entry represents an amino terminal extension of Pfam:PF00361. Only NADH-Ubiquinone chain 5 and eubacterial chain L are in this family. This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in ...	This entry represents an amino terminal extension of Pfam:PF00361. Only NADH-Ubiquinone chain 5 and eubacterial chain L are in this family. This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.	Domain
D [auth 4]	PF00361	NADH:quinone oxidoreductase/Mrp antiporter, TM (Proton_antipo_M)	NADH:quinone oxidoreductase/Mrp antiporter, TM	This entry includes membrane transporters and represents some 7 of potentially 14-16 TM regions. In many instances, its members forms part of complex I that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associa ...	This entry includes membrane transporters and represents some 7 of potentially 14-16 TM regions. In many instances, its members forms part of complex I that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N [1]. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction [2].	Domain
C [auth 3]	PF00507	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 (Oxidored_q4)	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	Family
B [auth 2]	PF00361	NADH:quinone oxidoreductase/Mrp antiporter, TM (Proton_antipo_M)	NADH:quinone oxidoreductase/Mrp antiporter, TM	This entry includes membrane transporters and represents some 7 of potentially 14-16 TM regions. In many instances, its members forms part of complex I that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associa ...	This entry includes membrane transporters and represents some 7 of potentially 14-16 TM regions. In many instances, its members forms part of complex I that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N [1]. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction [2].	Domain
O [auth L]	PF00420	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L (Oxidored_q2)	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	Family
N [auth K]	PF01058	NADH ubiquinone oxidoreductase, 20 Kd subunit (Oxidored_q6)	NADH ubiquinone oxidoreductase, 20 Kd subunit		Domain
M [auth I]	PF12838	4Fe-4S dicluster domain (Fer4_7)	4Fe-4S dicluster domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contai ...	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	Domain
K [auth G]	PF00329	Respiratory-chain NADH dehydrogenase, 30 Kd subunit (Complex1_30kDa)	Respiratory-chain NADH dehydrogenase, 30 Kd subunit		Domain
A [auth 1]	PF00146	NADH dehydrogenase (NADHdh)	NADH dehydrogenase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
I [auth C]	NUCM protein	NAD binding binding nucleoside phosphate binding purine nucleotide binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on NAD(P)H catalytic activity quinone binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, NADH to ubiquinone respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle
H [auth B]	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	FMN binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity FMN binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity NAD binding purine nucleotide binding adenyl nucleotide binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding cation binding metal ion binding	-	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure organelle mitochondrial envelope cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure organelle mitochondrial envelope cytoplasm organelle membrane
G [auth A]	NUAM protein	iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity 4 iron, 4 sulfur cluster binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy	cellular anatomical structure membrane
F [auth 6]	NADH-ubiquinone oxidoreductase chain 6	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	-	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure organelle mitochondrial envelope cytoplasm organelle membrane
E [auth 5]	NADH-ubiquinone oxidoreductase chain 5	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport establishment of localization monoatomic cation transmembrane transport transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport monoatomic cation transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure organelle mitochondrial envelope cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure organelle mitochondrial envelope cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex membrane protein complex transporter complex NADH dehydrogenase complex transmembrane transporter complex respiratory chain complex I oxidoreductase complex
JB [auth AD]	Unknown polypeptide	-	-	-
GB [auth AA]	Unknown polypeptide	-	-	-
DB [auth x], MB [auth AG]	Unknown polypeptide	-	-	-
BB [auth v], EB [auth y]	Unknown polypeptide	-	-	-
AB [auth u]	Unknown polypeptide	-	-	-
ZA [auth t]	Unknown polypeptide	-	-	-
VA [auth p]	Unknown polypeptide	-	-	-
TA [auth n], WA [auth q]	Unknown polypeptide	-	-	-
QA [auth k], YA [auth s]	Unknown polypeptide	-	-	-
D [auth 4]	NADH-ubiquinone oxidoreductase chain 4	binding quinone binding ubiquinone binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity binding quinone binding ubiquinone binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport establishment of localization monoatomic cation transmembrane transport transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport monoatomic cation transport	respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex cellular anatomical structure transmembrane transporter complex respiratory chain complex I oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex cellular anatomical structure transmembrane transporter complex respiratory chain complex I oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope organelle mitochondrial envelope cytoplasm organelle membrane
PA [auth j]	Unknown polypeptide	-	-	-
NA [auth h]	Unknown polypeptide	-	-	-
CB [auth w], FB [auth z], KA [auth e]	Unknown polypeptide	-	-	-
HB [auth AB], JA [auth d], TB [auth AN], UA [auth o]	Unknown polypeptide	-	-	-
IA [auth c], KB [auth AE], MA [auth g], QB [auth AK], UB [auth AO]	Unknown polypeptide	-	-	-
HA [auth b]	Unknown polypeptide	-	-	-
GA [auth a], OA [auth i]	Unknown polypeptide	-	-	-
FA [auth N]	Unknown polypeptide	-	-	-
EA [auth J]	Unknown polypeptide	-	-	-
DA [auth D]	Unknown polypeptide	-	-	-
C [auth 3]	NADH-ubiquinone oxidoreductase chain 3	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	-	respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex cellular anatomical structure transmembrane transporter complex respiratory chain complex I oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex cellular anatomical structure transmembrane transporter complex respiratory chain complex I oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope organelle mitochondrial envelope cytoplasm organelle membrane
CA [auth M]	Unknown polypeptide	-	-	-
BA [auth O], RA [auth l]	Unknown polypeptide	-	-	-
AA [auth F], IB [auth AC], LA [auth f], NB [auth AH], SB [auth AM]	Unknown polypeptide	-	-	-
Z [auth P]	Unknown polypeptide	-	-	-
Y [auth Q]	Unknown polypeptide	-	-	-
X [auth R]	Unknown polypeptide	-	-	-
PB [auth AJ], RB [auth AL], W [auth S]	Unknown polypeptide	-	-	-
OB [auth AI], SA [auth m], V [auth T]	Unknown polypeptide	-	-	-
U [auth V]	Unknown polypeptide	-	-	-
T [auth W]	Unknown polypeptide	-	-	-
B [auth 2]	NADH-ubiquinone oxidoreductase chain 2,NADH dehydrogenase subunit 2	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	-	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure organelle mitochondrial envelope cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure organelle mitochondrial envelope cytoplasm organelle membrane
S [auth X]	Unknown polypeptide	-	-	-
R [auth U]	Unknown polypeptide	-	-	-
LB [auth AF], Q [auth Y]	Unknown polypeptide	-	-	-
P [auth Z], XA [auth r]	Unknown polypeptide	-	-	-
O [auth L]	NADH-ubiquinone oxidoreductase chain 4L	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy	respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex cellular anatomical structure transmembrane transporter complex respiratory chain complex I oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex cellular anatomical structure transmembrane transporter complex respiratory chain complex I oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope organelle mitochondrial envelope cytoplasm organelle membrane
N [auth K]	Subunit NUKM of protein NADH:Ubiquinone Oxidoreductase (Complex I)	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding ion binding metal ion binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding ion binding metal ion binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity quinone binding	electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport establishment of localization monoatomic cation transmembrane transport transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport cellular process monoatomic cation transport protein-containing complex organization NADH dehydrogenase complex assembly electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport establishment of localization monoatomic cation transmembrane transport transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport cellular process monoatomic cation transport protein-containing complex organization NADH dehydrogenase complex assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly mitochondrial respiratory chain complex assembly protein-containing complex assembly cellular component organization or biogenesis mitochondrial respiratory chain complex I assembly mitochondrion organization aerobic respiration cellular respiration energy derivation by oxidation of organic compounds metabolic process generation of precursor metabolites and energy	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex transmembrane transporter complex respiratory chain complex I oxidoreductase complex
M [auth I]	Subunit NUIM of NADH:Ubiquinone Oxidoreductase (Complex I)	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on NAD(P)H catalytic activity NADH dehydrogenase activity cation binding ion binding metal ion binding	protein-containing complex organization NADH dehydrogenase complex assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly mitochondrial respiratory chain complex assembly protein-containing complex assembly cellular process cellular component organization or biogenesis mitochondrial respiratory chain complex I assembly mitochondrion organization aerobic respiration cellular respiration protein-containing complex organization NADH dehydrogenase complex assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly mitochondrial respiratory chain complex assembly protein-containing complex assembly cellular process cellular component organization or biogenesis mitochondrial respiratory chain complex I assembly mitochondrion organization aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, NADH to ubiquinone respiratory electron transport chain metabolic process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane
L [auth H]	Subunit NUHM of NADH:Ubiquinone Oxidoreductase (Complex I)	-	-	-
K [auth G]	NUGM protein	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	-	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane
J [auth E]	NUEM protein	-	-	-
A [auth 1]	NADH-ubiquinone oxidoreductase chain 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	aerobic respiration cellular respiration energy derivation by oxidation of organic compounds metabolic process cellular process generation of precursor metabolites and energy	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure organelle mitochondrial envelope cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure organelle mitochondrial envelope cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex membrane protein complex transporter complex NADH dehydrogenase complex transmembrane transporter complex respiratory chain complex I oxidoreductase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
I [auth C]	IPR022885	NAD(P)H-quinone oxidoreductase subunit D/H	Family
I [auth C]	IPR014029	NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site	Conserved Site
I [auth C]	IPR029014	[NiFe]-hydrogenase, large subunit	Homologous Superfamily
I [auth C]	IPR001135	NADH-quinone oxidoreductase, subunit D	Domain
H [auth B]	IPR019575	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	Domain
H [auth B]	IPR054765	SLBB domain	Domain
H [auth B]	IPR011537	NADH ubiquinone oxidoreductase, F subunit	Family
H [auth B]	IPR001949	NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site	Conserved Site
H [auth B]	IPR037225	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily	Homologous Superfamily
H [auth B]	IPR037207	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily	Homologous Superfamily
H [auth B]	IPR011538	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain	Domain
H [auth B]	IPR050837	Complex I 51 kDa subunit	Family
G [auth A]	IPR006963	Molybdopterin oxidoreductase, 4Fe-4S domain	Domain
G [auth A]	IPR015405	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like	Domain
G [auth A]	IPR006656	Molybdopterin oxidoreductase	Domain
G [auth A]	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
G [auth A]	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
G [auth A]	IPR000283	NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site	Conserved Site
G [auth A]	IPR054351	NADH-ubiquinone oxidoreductase, ferredoxin-like domain	Domain
G [auth A]	IPR010228	NADH:ubiquinone oxidoreductase, subunit G	Family
G [auth A]	IPR050123	Prokaryotic molybdopterin-containing oxidoreductase	Family
G [auth A]	IPR019574	NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding	Domain
F [auth 6]	IPR042106	NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ	Homologous Superfamily
F [auth 6]	IPR001457	NADH:ubiquinone/plastoquinone oxidoreductase, chain 6	Family
E [auth 5]	IPR003945	NADH-quinone oxidoreductase, chain 5-like	Family
E [auth 5]	IPR001516	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal	Domain
E [auth 5]	IPR001750	NADH:quinone oxidoreductase/Mrp antiporter, transmembrane domain	Domain
E [auth 5]	IPR018393	NADH-plastoquinone oxidoreductase, chain 5 subgroup	Family
D [auth 4]	IPR003918	NADH:ubiquinone oxidoreductase	Family
D [auth 4]	IPR010227	NADH-quinone oxidoreductase, chain M/4	Family
D [auth 4]	IPR001750	NADH:quinone oxidoreductase/Mrp antiporter, transmembrane domain	Domain
C [auth 3]	IPR000440	NADH:ubiquinone/plastoquinone oxidoreductase, chain 3	Family
C [auth 3]	IPR038430	NADH:ubiquinone oxidoreductase, subunit 3 superfamily	Homologous Superfamily
B [auth 2]	IPR001750	NADH:quinone oxidoreductase/Mrp antiporter, transmembrane domain	Domain
O [auth L]	IPR001133	NADH-ubiquinone oxidoreductase chain 4L/K	Family
O [auth L]	IPR039428	NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like	Family
N [auth K]	IPR006138	NADH-ubiquinone oxidoreductase, 20 Kd subunit	Family
N [auth K]	IPR006137	NADH:ubiquinone oxidoreductase-like, 20kDa subunit	Domain
M [auth I]	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	Conserved Site
M [auth I]	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain
M [auth I]	IPR010226	NADH-quinone oxidoreductase, chain I	Family
K [auth G]	IPR037232	NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily	Homologous Superfamily
K [auth G]	IPR001268	NADH:ubiquinone oxidoreductase, 30kDa subunit	Domain
K [auth G]	IPR020396	NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site	Conserved Site
K [auth G]	IPR010218	NADH dehydrogenase, subunit C	Family
A [auth 1]	IPR001694	NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H	Family
A [auth 1]	IPR018086	NADH:ubiquinone oxidoreductase, subunit 1, conserved site	Conserved Site

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5] A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], F [auth 6], H [auth B], O [auth L]	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex I (NADH dehydrogenase) and supercomplexes	H+ or Na+ translocating NADH dehydrogenase