6HFX

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	FtsX	e6hfxB1	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: FtsX	ECOD (1.6)
B [auth A]	FtsX	e6hfxA1	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: FtsX	ECOD (1.6)

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF18075	FtsX extracellular domain (FtsX_ECD)	FtsX extracellular domain	This is the extracellular domain (ECD) found in FtsX enzyme, a homolog of the transmembrane PG-hydrolase regulator. The FtsX extracellular domain binds the PG peptidase Rv2190c/RipC N-terminal segment, causing a conformational change that activates t ...	This is the extracellular domain (ECD) found in FtsX enzyme, a homolog of the transmembrane PG-hydrolase regulator. The FtsX extracellular domain binds the PG peptidase Rv2190c/RipC N-terminal segment, causing a conformational change that activates the enzyme ileading to PG hydrolysis in Mycobacterium tuberculosis. Structural analysis of FtsX ECD reveals fold containing two lobes connected by a flexible hinge. Mutations in the hydrophobic cleft between the lobes showed reduction in RipC binding in vitro and inhibition of FtsX function in Mycobacterium smegmatis [1].	Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Cell division protein FtsX	-	cellular process cell division	cell periphery cellular anatomical structure plasma membrane membrane

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR040690	FtsX, extracellular domain	Domain
A [auth B], B [auth A]	IPR003838	ABC3 transporter permease, C-terminal	Domain
A [auth B], B [auth A]	IPR004513	Cell division protein FtsX	Family