Annotations: 6I6M

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d6i6mb1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	Opium poppy (Papaver somniferum ) [TaxId: 3469 ],	SCOPe (2.08)
B	d6i6mb2	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	Opium poppy (Papaver somniferum ) [TaxId: 3469 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Dimerisation	e6i6mA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dimerisation	ECOD (1.6)
A	Methyltransf_11_4	e6i6mA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Methyltransf_11_4	ECOD (1.6)
B	Dimerisation	e6i6mB2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dimerisation	ECOD (1.6)
B	Methyltransf_11_4	e6i6mB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Methyltransf_11_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (utative)
B	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (utative)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	O-methyltransferase 1	transferase activity, transferring one-carbon groups tetrahydrocolumbamine 2-O-methyltransferase activity transferase activity methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity catalytic activity O-methyltransferase activity (S)-scoulerine 9-O-methyltransferase activity protein binding binding protein dimerization activity	alkaloid biosynthetic process secondary metabolite biosynthetic process biosynthetic process benzyl isoquinoline alkaloid biosynthetic process isoquinoline alkaloid biosynthetic process alkaloid metabolic process metabolic process cellular process isoquinoline alkaloid metabolic process secondary metabolic process methylation	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR016461	O-methyltransferase-like	Family
A, B	IPR001077	O-methyltransferase, C-terminal domain	Domain
A, B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR012967	Caffeic acid 3-O-methyltransferase-like, dimerisation domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.