Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6jy3a_ Membrane and cell surface proteins and peptides Cytochrome c oxidase subunit I-like Cytochrome c oxidase subunit I-like Cytochrome c oxidase subunit I-like Mitochondrial cytochrome c oxidase, subunit I (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Cd6jy3c_ Membrane and cell surface proteins and peptides Cytochrome c oxidase subunit III-like Cytochrome c oxidase subunit III-like Cytochrome c oxidase subunit III-like Mitochondrial cytochrome c oxidase, subunit III (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Dd6jy3d_ Membrane and cell surface proteins and peptides Single transmembrane helix Mitochondrial cytochrome c oxidase subunit IV Mitochondrial cytochrome c oxidase subunit IV Mitochondrial cytochrome c oxidase subunit IV (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ed6jy3e_ All alpha proteins alpha-alpha superhelix Cytochrome c oxidase subunit E Cytochrome c oxidase subunit E Cytochrome c oxidase subunit E (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Gd6jy3g_ Membrane and cell surface proteins and peptides Single transmembrane helix Mitochondrial cytochrome c oxidase subunit VIa Mitochondrial cytochrome c oxidase subunit VIa Mitochondrial cytochrome c oxidase subunit VIa (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Hd6jy3h_ All alpha proteins Cytochrome c oxidase subunit h Cytochrome c oxidase subunit h Cytochrome c oxidase subunit h Cytochrome c oxidase subunit h (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Id6jy3i_ Membrane and cell surface proteins and peptides Single transmembrane helix Mitochondrial cytochrome c oxidase subunit VIc Mitochondrial cytochrome c oxidase subunit VIc Mitochondrial cytochrome c oxidase subunit VIc (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Jd6jy3j_ Membrane and cell surface proteins and peptides Single transmembrane helix Mitochondrial cytochrome c oxidase subunit VIIa Mitochondrial cytochrome c oxidase subunit VIIa Mitochondrial cytochrome c oxidase subunit VIIa (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Kd6jy3k_ Membrane and cell surface proteins and peptides Single transmembrane helix Mitochondrial cytochrome c oxidase subunit VIIb Mitochondrial cytochrome c oxidase subunit VIIb Mitochondrial cytochrome c oxidase subunit VIIb (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ld6jy3l_ Membrane and cell surface proteins and peptides Single transmembrane helix Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Md6jy3m_ Membrane and cell surface proteins and peptides Single transmembrane helix Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd6jy3b2 All beta proteins Cupredoxin-like Cupredoxins Periplasmic domain of cytochrome c oxidase subunit II Cytochrome c oxidase (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd6jy3b1 Membrane and cell surface proteins and peptides Transmembrane helix hairpin Cytochrome c oxidase subunit II-like, transmembrane region Cytochrome c oxidase subunit II-like, transmembrane region Mitochondrial cytochrome c oxidase, subunit II (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Fd6jy3f_ Small proteins Rubredoxin-like Rubredoxin-like Cytochrome c oxidase Subunit F Cytochrome c oxidase Subunit F (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCytochrome c oxidase subunit I-like 8035426 3000653 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCytochrome c oxidase subunit III-like 8035429 3000671 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyMitochondrial cytochrome c oxidase subunit IV 8035430 3000582 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyCytochrome c oxidase subunit E 8035431 3001402 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyMitochondrial cytochrome c oxidase subunit VIa 8035433 3000592 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyCytochrome c oxidase subunit h 8035435 3000395 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyMitochondrial cytochrome c oxidase subunit VIc 8035437 3000598 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMitochondrial cytochrome c oxidase subunit VIIa 8035438 3000606 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMitochondrial cytochrome c oxidase subunit VIIb 8035440 3000613 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) 8035441 3000624 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyMitochondrial cytochrome c oxidase subunit VIIIb (aka IX) 8035443 3000633 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCupredoxins 8035427 3000886 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCytochrome c oxidase subunit II-like, transmembrane region 8035428 3000692 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyRubredoxin-like 8035432 3001257 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ACOX1e6jy3A1 A: alpha superhelicesX: Cytochrome c oxidase subunit I-likeH: Cytochrome c oxidase subunit I-like (From Topology)T: Cytochrome c oxidase subunit I-likeF: COX1ECOD (1.6)
CCOX3e6jy3C1 A: alpha bundlesX: Cytochrome c oxidase subunit III-like (From Topology)H: Cytochrome c oxidase subunit III-like (From Topology)T: Cytochrome c oxidase subunit III-likeF: COX3ECOD (1.6)
DCOX4e6jy3D1 A: extended segmentsX: Mitochondrial cytochrome c oxidase subunit IV (From Topology)H: Mitochondrial cytochrome c oxidase subunit IV (From Topology)T: Mitochondrial cytochrome c oxidase subunit IVF: COX4ECOD (1.6)
ECOX5Ae6jy3E1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Cytochrome c oxidase subunit E (From Topology)T: Cytochrome c oxidase subunit EF: COX5AECOD (1.6)
GCOX6Ae6jy3G1 A: extended segmentsX: Mitochondrial cytochrome c oxidase subunit VIa (From Topology)H: Mitochondrial cytochrome c oxidase subunit VIa (From Topology)T: Mitochondrial cytochrome c oxidase subunit VIaF: COX6AECOD (1.6)
HCOX6Be6jy3H1 A: few secondary structure elementsX: Cytochrome c oxidase subunit h (From Topology)H: Cytochrome c oxidase subunit h (From Topology)T: Cytochrome c oxidase subunit hF: COX6BECOD (1.6)
ICOX6Ce6jy3I1 A: extended segmentsX: Mitochondrial cytochrome c oxidase subunit VIc (From Topology)H: Mitochondrial cytochrome c oxidase subunit VIc (From Topology)T: Mitochondrial cytochrome c oxidase subunit VIcF: COX6CECOD (1.6)
JCOX7ae6jy3J1 A: extended segmentsX: Mitochondrial cytochrome c oxidase subunit VIIa (From Topology)H: Mitochondrial cytochrome c oxidase subunit VIIa (From Topology)T: Mitochondrial cytochrome c oxidase subunit VIIaF: COX7aECOD (1.6)
KCOX7Be6jy3K1 A: extended segmentsX: Mitochondrial cytochrome c oxidase subunit VIIb (From Topology)H: Mitochondrial cytochrome c oxidase subunit VIIb (From Topology)T: Mitochondrial cytochrome c oxidase subunit VIIbF: COX7BECOD (1.6)
LCOX7Ce6jy3L1 A: extended segmentsX: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) (From Topology)H: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) (From Topology)T: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)F: COX7CECOD (1.6)
MCOX8e6jy3M1 A: extended segmentsX: Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) (From Topology)H: Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) (From Topology)T: Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX)F: COX8ECOD (1.6)
BCOX2e6jy3B2 A: beta sandwichesX: Cupredoxin-likeH: Cupredoxin-related (From Topology)T: Cupredoxin-relatedF: COX2ECOD (1.6)
BCOX2_TMe6jy3B1 A: extended segmentsX: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)H: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)T: Cytochrome c oxidase subunit II-like, transmembrane regionF: COX2_TMECOD (1.6)
FCOX5Be6jy3F1 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Cytochrome c oxidase Subunit FF: COX5BECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00115Cytochrome C and Quinol oxidase polypeptide I (COX1)Cytochrome C and Quinol oxidase polypeptide I- Family
PF00510Cytochrome c oxidase subunit III (COX3)Cytochrome c oxidase subunit III- Family
PF02297Cytochrome oxidase c subunit VIb (COX6B)Cytochrome oxidase c subunit VIbCytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the potentially heme-binding subunit IVb of the oxidase.Domain
PF02937Cytochrome c oxidase subunit VIc (COX6C)Cytochrome c oxidase subunit VIc- Family
PF02238Cytochrome c oxidase subunit VII (COX7a)Cytochrome c oxidase subunit VII- Family
PF02285Cytochrome oxidase c subunit VIII (COX8)Cytochrome oxidase c subunit VIII- Family
PF00116Cytochrome C oxidase subunit II, periplasmic domain (COX2)Cytochrome C oxidase subunit II, periplasmic domain- Domain
PF02790Cytochrome C oxidase subunit II, transmembrane domain (COX2_TM)Cytochrome C oxidase subunit II, transmembrane domain- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Cytochrome c oxidase subunit 1
Cytochrome c oxidase subunit 3
Cytochrome c oxidase subunit 4 isoform 1
Cytochrome c oxidase subunit 5A
Cytochrome c oxidase subunit 6A2, mitochondrial
Cytochrome c oxidase subunit 6B1-
Cytochrome c oxidase subunit 6C-
Cytochrome c oxidase subunit 7A1
Cytochrome c oxidase subunit 7B-
Cytochrome c oxidase subunit 7C, mitochondrial-
Cytochrome c oxidase subunit 8B-
Cytochrome c oxidase subunit 2
Cytochrome c oxidase subunit 5B

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR036927Cytochrome c oxidase-like, subunit I superfamilyHomologous Superfamily
IPR000883Cytochrome c oxidase subunit IFamily
IPR023615Cytochrome c oxidase, subunit I, copper-binding siteBinding Site
IPR023616Cytochrome c oxidase-like, subunit I domainDomain
IPR033944Cytochrome c oxidase subunit I domainDomain
IPR035973Cytochrome c oxidase subunit III-like superfamilyHomologous Superfamily
IPR013833Cytochrome c oxidase, subunit III, 4-helical bundleHomologous Superfamily
IPR000298Cytochrome c oxidase subunit III-likeDomain
IPR033945Cytochrome c oxidase subunit III domainDomain
IPR024791Cytochrome c oxidase subunit IIIFamily
IPR004203Cytochrome c oxidase subunit IV familyFamily
IPR013288Cytochrome c oxidase subunit IVFamily
IPR036639Cytochrome c oxidase subunit IV superfamilyHomologous Superfamily
IPR003204Cytochrome c oxidase, subunit Va/VIFamily
IPR036545Cytochrome c oxidase, subunit Va/VI superfamilyHomologous Superfamily
IPR018507Cytochrome c oxidase, subunit VIa, conserved siteConserved Site
IPR036418Cytochrome c oxidase, subunit VIa superfamilyHomologous Superfamily
IPR001349Cytochrome c oxidase, subunit VIaFamily
IPR036549Cytochrome c oxidase subunit 6B/Cytochrome c oxidase assembly factor 6-like superfamilyHomologous Superfamily
IPR048280Cytochrome oxidase c subunit VIb-likeFamily
IPR003213Cytochrome c oxidase, subunit VIbFamily
IPR037169Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamilyHomologous Superfamily
IPR051389Cytochrome c oxidase subunit VIcFamily
IPR034884Mitochondrial cytochrome c oxidase subunit VIc/VIIsFamily
IPR003177Cytochrome c oxidase subunit VIIa, metazoaFamily
IPR036539Cytochrome c oxidase, subunit VIIa superfamilyHomologous Superfamily
IPR039297Cytochrome c oxidase subunit VIIFamily
IPR023272Cytochrome C oxidase, subunit VIIB domain superfamilyHomologous Superfamily
IPR008433Cytochrome C oxidase, subunit VIIBFamily
IPR036636Cytochrome c oxidase subunit VIIc superfamilyHomologous Superfamily
IPR004202Cytochrome c oxidase subunit VIIcFamily
IPR003205Cytochrome c oxidase, subunit 8Family
IPR036548Cytochrome c oxidase, subunit 8 superfamilyHomologous Superfamily
IPR011759Cytochrome C oxidase subunit II, transmembrane domainDomain
IPR036257Cytochrome C oxidase subunit II, transmembrane domain superfamilyHomologous Superfamily
IPR034210Cytochrome c oxidase subunit 2, C-terminalDomain
IPR045187Cytochrome c/quinol oxidase subunit IIFamily
IPR002429Cytochrome c oxidase subunit II-like C-terminalDomain
IPR008972CupredoxinHomologous Superfamily
IPR001505Copper centre Cu(A)Binding Site
IPR014222Cytochrome c oxidase, subunit IIDomain
IPR002124Cytochrome c oxidase, subunit VbFamily
IPR036972Cytochrome c oxidase, subunit Vb superfamilyHomologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
A, B, C, D, E
PDBTMAnnotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

ChainsExternal LinkComment
A, B, C, D, E
MemProtMDAnnotated as membrane protein by MemProtMD

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
FME Parent Component: MET

RESIDAA0021 , AA0566

PSI-MOD :  N-formyl-L-methionine residue MOD:00030 , N-formyl-L-methionine (Met) MOD:00482 , N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) MOD:01890 , N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) MOD:01891
FME Parent Component: MET

RESIDAA0021 , AA0566 , AA0021 , AA0566

PSI-MOD :  N-formyl-L-methionine residue MOD:00030 , N-formyl-L-methionine (Met) MOD:00482 , N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) MOD:01890 , N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) MOD:01891 , N-formyl-L-methionine residue MOD:00030 , N-formyl-L-methionine (Met) MOD:00482 , N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) MOD:01890 , N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) MOD:01891