6V1Y | pdb_00006v1y

Cryo-EM Structure of the Hyperpolarization-Activated Potassium Channel KAT1: Octamer

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
H [auth P]	cNMP_binding_1	e6v1yP2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
H [auth P]	Ion_trans_2_1	e6v1yP1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
G [auth O]	cNMP_binding_1	e6v1yO2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
G [auth O]	Ion_trans_2_1	e6v1yO1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
F [auth N]	cNMP_binding_1	e6v1yN2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
F [auth N]	Ion_trans_2_1	e6v1yN1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
E [auth M]	cNMP_binding_1	e6v1yM2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
E [auth M]	Ion_trans_2_1	e6v1yM1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
D	cNMP_binding_1	e6v1yD2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
D	Ion_trans_2_1	e6v1yD1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
C	cNMP_binding_1	e6v1yC2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
C	Ion_trans_2_1	e6v1yC1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
B	cNMP_binding_1	e6v1yB2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
B	Ion_trans_2_1	e6v1yB1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
A	cNMP_binding_1	e6v1yA2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding_1	ECOD (1.6)
A	Ion_trans_2_1	e6v1yA1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	PF07885	Ion channel (Ion_trans_2)	Ion channel	-	Family
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	PF00027	Cyclic nucleotide-binding domain (cNMP_binding)	Cyclic nucleotide-binding domain	This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	Potassium channel KAT1	inward rectifier potassium channel activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity channel activity inward rectifier potassium channel activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity identical protein binding protein binding binding	-	cell periphery cellular anatomical structure plasma membrane membrane protein-containing complex transmembrane transporter complex membrane protein complex transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	IPR005821	Ion transport domain	Domain
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG-like	Family
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	IPR021789	KHA domain	Domain
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	IPR045319	Potassium channel KAT/AKT	Family
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	IPR000595	Cyclic nucleotide-binding domain	Domain
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily
A, B, C, D, E [auth M], A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E [auth M] A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Plant inwardly rectifying potassium channel

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E [auth M] A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E [auth M] A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E [auth M] A, B, C, D, E [auth M], F [auth N], G [auth O], H [auth P]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	KAT1 Hyperpolarization-Activated Potassium Channel, tetramer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.