6ZFG

14-3-3 zeta chimera with 18E6 and fusicoccin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6zfga_	All alpha proteins	alpha-alpha superhelix	14-3-3 protein	14-3-3 protein	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], (human papillomavirus 18 ) [TaxId: 333761 ],	SCOPe (2.08)
B	d6zfgb1	All alpha proteins	alpha-alpha superhelix	14-3-3 protein	14-3-3 protein	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], (human papillomavirus 18 ) [TaxId: 333761 ],	SCOPe (2.08)
B	d6zfgb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ], (human papillomavirus 18 ) [TaxId: 333761 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	14-3-3 protein	8034961	3001329	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	14-3-3 protein	8034961	3001329	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	14-3-3	e6zfgA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)
B	14-3-3	e6zfgB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (utative)
B	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00244	14-3-3 protein (14-3-3)	14-3-3 protein	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	14-3-3 protein zeta/delta,Protein E6	DNA binding binding organic cyclic compound binding nucleic acid binding protein binding PDZ domain binding protein domain specific binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding phosphoprotein binding DNA binding binding organic cyclic compound binding nucleic acid binding protein binding PDZ domain binding protein domain specific binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding phosphoprotein binding phosphoserine residue binding protein phosphorylated amino acid binding molecular sequestering activity protein sequestering activity RNA binding transmembrane transporter binding kinase binding enzyme binding protein kinase binding cell adhesion molecule binding cadherin binding transcription factor binding DNA-binding transcription factor binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding identical protein binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process symbiont-mediated perturbation of host defense response biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process viral process modulation by virus of host process virus-mediated perturbation of host defense response modulation of process of another organism biological process involved in interaction with host modulation by virus of host cellular process biological process involved in symbiotic interaction symbiont-mediated perturbation of host cellular process response to stimulus symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway response to biotic stimulus symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway response to host defenses response to other organism symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host defenses response to defenses of other organism response to external stimulus symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway symbiont-mediated perturbation of host ubiquitin-like protein modification symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated perturbation of host programmed cell death regulation of killing of cells of another organism disruption of cell in another organism regulation of cell killing symbiont-mediated perturbation of host apoptosis disruption of anatomical structure in another organism killing of cells of another organism cell killing Golgi localization establishment of organelle localization localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell establishment of localization protein localization cellular macromolecule localization macromolecule localization developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death cellular response to stimulus cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress response to starvation cellular response to glucose starvation cellular response to starvation signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade signal transduction regulation of defense response regulation of response to biotic stimulus negative regulation of response to biotic stimulus regulation of response to external stimulus regulation of response to stress innate immune response regulation of immune system process negative regulation of response to stimulus immune response defense response regulation of innate immune response negative regulation of immune response defense response to symbiont regulation of response to stimulus negative regulation of immune system process immune system process defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response negative regulation of innate immune response animal organ development respiratory tube development lung development respiratory system development Golgi inheritance organelle inheritance Golgi reassembly cellular component organization cellular component biogenesis organelle organization cellular component assembly cellular component organization or biogenesis Golgi organization endomembrane system organization regulation of cellular component organization regulation of developmental process nervous system development developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality regulation of protein stability system process respiratory system process respiratory gaseous exchange by respiratory system protein phosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process establishment of protein localization protein targeting regulation of signaling regulation of signal transduction regulation of MAPK cascade regulation of intracellular signal transduction regulation of cell communication regulation of ERK1 and ERK2 cascade negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of TORC1 signaling negative regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of TOR signaling negative regulation of signal transduction TORC1 signaling neuron recognition cellular developmental process cell development synaptic target recognition generation of neurons neurogenesis neuron differentiation cell differentiation neuron development cell recognition regulation of localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus regulation of cellular localization protein localization to organelle negative regulation of protein localization transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II tube formation	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle host cell cytoplasm anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle host cell cytoplasm anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen synapse glutamatergic synapse blood microparticle neuron to neuron synapse hippocampal mossy fiber to CA3 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR038575	E6 superfamily	Homologous Superfamily
A, B	IPR001334	E6 early regulatory protein	Family
A, B	IPR023409	14-3-3 protein, conserved site	Conserved Site
A, B	IPR023410	14-3-3 domain	Domain
A, B	IPR036815	14-3-3 domain superfamily	Homologous Superfamily
A, B	IPR000308	14-3-3 protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P63104	Mammary Neoplasms, Experimental Parkinson disease carcinoma sarcomatoid carcinoma mammary neoplasms, animal myopathy ovarian cancer paranoid schizophrenia plasma cell myeloma atypical teratoid rhabdoid tumor undifferentiated carcinoma breast carcinoma Creutzfeldt Jacob disease invasive ductal breast carcinoma lung adenocarcinoma Mammary Neoplasms, Experimental Parkinson disease carcinoma sarcomatoid carcinoma mammary neoplasms, animal myopathy ovarian cancer paranoid schizophrenia plasma cell myeloma atypical teratoid rhabdoid tumor undifferentiated carcinoma breast carcinoma Creutzfeldt Jacob disease invasive ductal breast carcinoma lung adenocarcinoma malignant glioma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor bipolar disorder glioblastoma large cell medulloblastoma lung cancer medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma astrocytic tumor breast cancer IgA glomerulonephritis malignant ependymoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	TPO	Parent Component: THR RESID: AA0038 PSI-MOD : O-phospho-L-threonine MOD:00047

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.