7JRX | pdb_00007jrx

Crystal structure of the R64F mutant of Bauhinia Bauhinioides complexed with Bovine Chymotrypsin

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
H [auth i]	SCOP2B Superfamily	STI-like	8070249	3000715	SCOP2B (2022-06-29)
D [auth I]	SCOP2B Superfamily	STI-like	8070249	3000715	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
H [auth i]	Kunitz_legume	e7jrxi1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Kunitz_legume	ECOD (1.6)
D [auth I]	Kunitz_legume	e7jrxI1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Kunitz_legume	ECOD (1.6)
G [auth c]	Trypsin_1	e7jrxc1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
C	Trypsin_1	e7jrxC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
B	Trypsin_1	e7jrxB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
F [auth b]	Trypsin_1	e7jrxb1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, G [auth c]	PF00089	Trypsin (Trypsin)	Trypsin		Domain
B, F [auth b]	PF00089	Trypsin (Trypsin)	Trypsin		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
D [auth I], H [auth i]	Kunitz-type inihibitor	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	-	cellular anatomical structure extracellular region
C, G [auth c]	Chymotrypsin A chain C	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding serpin family protein binding	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process multicellular organismal process digestion	protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex cellular anatomical structure extracellular region
B, F [auth b]	Chymotrypsin A chain B	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding serpin family protein binding	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process multicellular organismal process digestion	protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex cellular anatomical structure extracellular region
A, E [auth a]	Chymotrypsin A chain A	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding serpin family protein binding	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process multicellular organismal process digestion	protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D [auth I], H [auth i]	IPR002160	Proteinase inhibitor I3, Kunitz legume	Family
D [auth I], H [auth i]	IPR011065	Kunitz inhibitor STI-like superfamily	Homologous Superfamily
C, G [auth c]	IPR001254	Serine proteases, trypsin domain	Domain
C, G [auth c]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
C, G [auth c]	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
C, G [auth c]	IPR001314	Peptidase S1A, chymotrypsin family	Family
C, G [auth c]	IPR043504	Peptidase_S1_PA_chymotrypsin	Unknown
C, G [auth c]	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
B, F [auth b]	IPR001254	Serine proteases, trypsin domain	Domain
B, F [auth b]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B, F [auth b]	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
B, F [auth b]	IPR001314	Peptidase S1A, chymotrypsin family	Family
B, F [auth b]	IPR043504	Peptidase_S1_PA_chymotrypsin	Unknown
B, F [auth b]	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A, E [auth a]	IPR001254	Serine proteases, trypsin domain	Domain
A, E [auth a]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, E [auth a]	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A, E [auth a]	IPR001314	Peptidase S1A, chymotrypsin family	Family
A, E [auth a]	IPR043504	Peptidase_S1_PA_chymotrypsin	Unknown
A, E [auth a]	IPR033116	Serine proteases, trypsin family, serine active site	Active Site