Annotations: 7N84

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth a]	SCOP2B Superfamily	Scaffolding nucleoporins	8090980	3002255	SCOP2B (2022-06-29)
D [auth a]	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090978	3000456	SCOP2B (2022-06-29)
K [auth l]	SCOP2B Superfamily	Scaffolding nucleoporins	8090980	3002255	SCOP2B (2022-06-29)
K [auth l]	SCOP2B Superfamily	Nucleoporin beta-propeller domain	8090978	3000456	SCOP2B (2022-06-29)
E [auth b]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054123	3002276	SCOP2B (2022-06-29)
L [auth m]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054123	3002276	SCOP2B (2022-06-29)
F [auth c]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054129	3002276	SCOP2B (2022-06-29)
M [auth n]	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054129	3002276	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth a]	Nup160	e7n84a3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nup160	ECOD (1.6)
D [auth a]	EUF08019	e7n84a2	A: alpha arrays	X: Nucleoporin NUP120 helical domain (From Topology)	H: Nucleoporin NUP120 helical domain (From Topology)	T: Nucleoporin NUP120 helical domain	F: EUF08019	ECOD (1.6)
D [auth a]	KOG4521_2nd	e7n84a1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: KOG4521_2nd	ECOD (1.6)
K [auth l]	Nup160	e7n84l2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Nup160	ECOD (1.6)
K [auth l]	EUF08019	e7n84l3	A: alpha arrays	X: Nucleoporin NUP120 helical domain (From Topology)	H: Nucleoporin NUP120 helical domain (From Topology)	T: Nucleoporin NUP120 helical domain	F: EUF08019	ECOD (1.6)
K [auth l]	KOG4521_2nd	e7n84l1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains (From Topology)	T: Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains	F: KOG4521_2nd	ECOD (1.6)
E [auth b]	Nucleopor_Nup85	e7n84b1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nucleopor_Nup85	ECOD (1.6)
L [auth m]	Nucleopor_Nup85	e7n84m1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nucleopor_Nup85	ECOD (1.6)
F [auth c]	Nup96	e7n84c1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nup96	ECOD (1.6)
M [auth n]	Nup96	e7n84n1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: Nup96	ECOD (1.6)
G [auth d]	ANAPC4_WD40_19	e7n84d1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_19	ECOD (1.6)
N [auth o]	ANAPC4_WD40_19	e7n84o1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_19	ECOD (1.6)
H [auth e]	ANAPC4_WD40_6	e7n84e1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)
O [auth p]	ANAPC4_WD40_6	e7n84p1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X]	PF18378	Nuclear pore protein NUP188 C-terminal domain (Nup188_C)	Nuclear pore protein NUP188 C-terminal domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X]	Nucleoporin NUP188	structural molecule activity structural constituent of nuclear pore	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization protein localization establishment of protein localization nitrogen compound transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport cellular response to stimulus response to stimulus response to heat mRNA transport response to temperature stimulus cellular response to stress mRNA export from nucleus response to stress RNA localization nuclear export nucleobase-containing compound transport cellular response to heat RNA transport nucleic acid transport response to nitrogen compound gene expression macromolecule biosynthetic process RNA export from nucleus mRNA export from nucleus in response to heat stress establishment of RNA localization biosynthetic process response to chemical metabolic process response to abiotic stimulus macromolecule metabolic process	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane nuclear pore inner ring membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane nuclear pore inner ring protein-containing complex nuclear protein-containing complex nuclear pore
B [auth Y], C [auth Z]	unknown	-	-	-
D [auth a], K [auth l]	Nucleoporin NUP120	structural molecule activity structural constituent of nuclear pore identical protein binding protein binding binding	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization protein localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport subtelomeric heterochromatin formation regulation of cellular process negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process mRNA transport mRNA export from nucleus RNA localization nucleobase-containing compound transport RNA transport nucleic acid transport RNA export from nucleus establishment of RNA localization positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription cellular response to stimulus double-strand break repair response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of RNA metabolic process establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus ribosomal large subunit export from nucleus cellular component biogenesis ribosome biogenesis ribosome localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus positive regulation of transcription by RNA polymerase II response to heat response to temperature stimulus cellular response to heat response to nitrogen compound mRNA export from nucleus in response to heat stress response to chemical response to abiotic stimulus	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region
E [auth b], L [auth m]	Nucleoporin NUP85	structural molecule activity structural constituent of nuclear pore	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus ribosomal large subunit export from nucleus cellular component biogenesis ribosome biogenesis organelle localization nuclear export ribosome localization protein localization establishment of protein localization nitrogen compound transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport mRNA transport mRNA export from nucleus RNA localization nucleobase-containing compound transport RNA transport nucleic acid transport gene expression macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane
F [auth c], M [auth n]	Nucleoporin 145c	hydrolase activity catalytic activity RNA binding binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding structural molecule activity structural constituent of nuclear pore	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport nucleic acid transport intracellular transport tRNA export from nucleus establishment of localization RNA export from nucleus tRNA transport establishment of RNA localization establishment of localization in cell macromolecule localization RNA localization nuclear export nucleobase-containing compound transport protein localization protein localization to nucleus protein localization to membrane protein localization to nuclear envelope protein localization to organelle cellular macromolecule localization protein localization to nuclear inner membrane regulation of localization regulation of biological process regulation of cellular process regulation of transport biological regulation regulation of nucleocytoplasmic transport regulation of cellular localization regulation of intracellular transport establishment of protein localization import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport mRNA transport mRNA export from nucleus poly(A)+ mRNA export from nucleus gene expression macromolecule biosynthetic process biosynthetic process metabolic process macromolecule metabolic process NLS-bearing protein import into nucleus subtelomeric heterochromatin formation negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process regulation of macromolecule metabolic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription cellular response to stimulus double-strand break repair response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane nuclear pore central transport channel membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region nuclear pore cytoplasmic filaments
G [auth d], N [auth o]	Protein transport protein SEC13	structural molecule activity	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization regulation of localization regulation of cellular process transport positive regulation of biological process cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization regulation of localization regulation of cellular process transport positive regulation of biological process positive regulation of ER to Golgi vesicle-mediated transport vesicle-mediated transport establishment of localization in cell positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of biological process regulation of ER to Golgi vesicle-mediated transport regulation of transport biological regulation intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport regulation of vesicle-mediated transport establishment of localization positive regulation of transport regulation of cellular localization Golgi vesicle transport protein localization protein exit from endoplasmic reticulum establishment of protein localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport membrane organization vesicle budding from membrane vesicle organization COPII-coated vesicle budding RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway cellular response to stress response to chemical response to stress proteolysis metabolic process protein metabolic process macromolecule metabolic process response to endoplasmic reticulum stress positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction TOR signaling regulation of signaling regulation of TOR signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling nucleocytoplasmic transport nuclear transport regulation of TORC1 signaling TORC1 signaling protein localization to nucleus import into nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus regulation of protein exit from endoplasmic reticulum regulation of protein localization positive regulation of establishment of protein localization positive regulation of protein transport regulation of establishment of protein localization regulation of protein transport positive regulation of protein exit from endoplasmic reticulum positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport positive regulation of TORC1 signaling positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore cell periphery vesicle coat intracellular vesicle transport vesicle membrane membrane protein complex membrane coat bounding membrane of organelle vesicle membrane cytoplasmic vesicle ER to Golgi transport vesicle membrane coated vesicle vesicle transport vesicle membrane coated membrane COPII vesicle coat cytoplasmic vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle cytoplasm organelle membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane Seh1-associated complex vacuolar membrane vacuole
H [auth e], O [auth p]	Nucleoporin SEH1	structural molecule activity structural constituent of nuclear pore	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport response to nutrient levels cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels cellular response to stress response to stress response to amino acid starvation response to starvation	protein-containing complex Seh1-associated complex membrane-bounded organelle intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope protein-containing complex Seh1-associated complex membrane-bounded organelle intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane vacuolar membrane vacuole bounding membrane of organelle cytoplasm
I [auth f], P [auth q]	Nucleoporin NUP84	structural molecule activity structural constituent of nuclear pore identical protein binding protein binding binding	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization subtelomeric heterochromatin formation regulation of cellular process negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription silent mating-type cassette heterochromatin formation cellular response to stimulus double-strand break repair response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II response to heat response to temperature stimulus cellular response to heat response to nitrogen compound mRNA export from nucleus in response to heat stress response to chemical response to abiotic stimulus	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region
J [auth g], Q [auth r]	Nucleoporin NUP133	structural molecule activity structural constituent of nuclear pore	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization RNA transport nitrogen compound transport nucleocytoplasmic transport transport nuclear transport nucleic acid transport intracellular transport tRNA export from nucleus establishment of localization RNA export from nucleus tRNA transport establishment of RNA localization establishment of localization in cell macromolecule localization RNA localization nuclear export nucleobase-containing compound transport chromosome organization transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus regulation of cellular process negative regulation of biological process chromatin organization negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport mRNA transport mRNA export from nucleus response to nitrogen compound mRNA export from nucleus in response to heat stress response to chemical poly(A)+ mRNA export from nucleus subtelomeric heterochromatin formation positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription double-strand break repair DNA metabolic process DNA damage response DNA repair post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of RNA metabolic process positive regulation of transcription by RNA polymerase II	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane cytoplasm cytosol membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X]	IPR044840	Nucleoporin Nup188	Family
A [auth X]	IPR041634	Nuclear pore protein Nup188, C-terminal	Domain
A [auth X]	IPR048883	Nucleoporin Nup188, N-terminal subdomain III	Domain
A [auth X]	IPR018864	Nucleoporin Nup188, N-terminal	Domain
D [auth a], K [auth l]	IPR021717	Nucleoporin Nup120/160	Family
D [auth a], K [auth l]	IPR055090	Nucleoporin NUP120, helical domain, saccharomycetes	Domain
E [auth b], L [auth m]	IPR011502	Nucleoporin Nup85-like	Family
F [auth c], M [auth n]	IPR025574	Nucleoporin FG repeat	Repeat
F [auth c], M [auth n]	IPR037665	Nucleoporin peptidase S59-like	Family
F [auth c], M [auth n]	IPR036903	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily	Homologous Superfamily
F [auth c], M [auth n]	IPR007230	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain	Domain
F [auth c], M [auth n]	IPR021967	Nuclear pore complex protein NUP96, C-terminal domain	Domain
G [auth d], N [auth o]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
G [auth d], N [auth o]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
G [auth d], N [auth o]	IPR037363	Sec13/Seh1 family	Family
G [auth d], N [auth o]	IPR001680	WD40 repeat	Repeat
H [auth e], O [auth p]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
H [auth e], O [auth p]	IPR037363	Sec13/Seh1 family	Family
H [auth e], O [auth p]	IPR001680	WD40 repeat	Repeat
H [auth e], O [auth p]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
I [auth f], P [auth q]	IPR007252	Nuclear pore protein 84/107	Family
J [auth g], Q [auth r]	IPR037624	Nuclear pore complex protein Nup133-like	Family
J [auth g], Q [auth r]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
J [auth g], Q [auth r]	IPR014908	Nucleoporin, Nup133/Nup155-like, N-terminal	Domain