7PB0

Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium, GGsPP and IsPP

External Resource: Annotation

Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1180.10	Alpha Beta	3-Layer(aba) Sandwich	Undecaprenyl pyrophosphate synthetase	Decaprenyl diphosphate synthase-like	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01255	Putative undecaprenyl diphosphate synthase (Prenyltransf)	Putative undecaprenyl diphosphate synthase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Dehydrodolichyl diphosphate synthase complex subunit NUS1	prenyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity dehydrodolichyl diphosphate synthase activity cation binding ion binding binding metal ion binding small molecule binding	dolichol-linked oligosaccharide biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process phospholipid metabolic process protein N-linked glycosylation via asparagine phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process dolichyl diphosphate biosynthetic process carbohydrate derivative biosynthetic process dolichyl diphosphate metabolic process glycoprotein biosynthetic process primary metabolic process dolichol-linked oligosaccharide biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process phospholipid metabolic process protein N-linked glycosylation via asparagine phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process dolichyl diphosphate biosynthetic process carbohydrate derivative biosynthetic process dolichyl diphosphate metabolic process glycoprotein biosynthetic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process phospholipid biosynthetic process biosynthetic process organophosphate metabolic process glycosylation organophosphate biosynthetic process macromolecule modification macromolecule glycosylation metabolic process cellular process macromolecule metabolic process lipid metabolic process protein mannosylation mannosylation developmental process cellular developmental process cell differentiation positive regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process regulation of blood vessel endothelial cell migration endothelial cell migration biological regulation positive regulation of biological process positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion positive regulation of cellular process regulation of catalytic activity positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function regulation of monooxygenase activity positive regulation of monooxygenase activity regulation of nitric-oxide synthase activity polyprenol metabolic process polyprenol biosynthetic process small molecule biosynthetic process isoprenoid biosynthetic process organic hydroxy compound metabolic process alcohol metabolic process dolichol biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process small molecule metabolic process dolichol metabolic process isoprenoid metabolic process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development regulation of localization cellular localization transport regulation of intracellular sterol transport intracellular cholesterol transport regulation of lipid transport organic hydroxy compound transport intracellular sterol transport localization regulation of intracellular cholesterol transport establishment of localization in cell sterol transport regulation of cholesterol transport regulation of intracellular transport regulation of sterol transport regulation of transport intracellular lipid transport regulation of intracellular lipid transport lipid localization lipid transport intracellular transport establishment of localization regulation of lipid localization regulation of cellular localization macromolecule localization cholesterol transport cellular response to stimulus cellular response to growth factor stimulus cell surface receptor signaling pathway response to stimulus signaling response to endogenous stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication vascular endothelial growth factor signaling pathway cellular response to endogenous stimulus cellular response to vascular endothelial growth factor stimulus signal transduction response to growth factor enzyme-linked receptor protein signaling pathway sterol homeostasis chemical homeostasis homeostatic process cholesterol homeostasis lipid homeostasis	protein-containing complex catalytic complex polyprenyl diphosphate synthase complex transferase complex dehydrodolichyl diphosphate synthase complex membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure protein-containing complex catalytic complex polyprenyl diphosphate synthase complex transferase complex dehydrodolichyl diphosphate synthase complex membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane
A	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	prenyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity dehydrodolichyl diphosphate synthase activity cation binding ion binding binding metal ion binding small molecule binding	polyprenol metabolic process polyprenol biosynthetic process small molecule biosynthetic process isoprenoid biosynthetic process organic hydroxy compound metabolic process lipid biosynthetic process alcohol metabolic process primary metabolic process biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process small molecule metabolic process metabolic process cellular process polyprenol metabolic process polyprenol biosynthetic process small molecule biosynthetic process isoprenoid biosynthetic process organic hydroxy compound metabolic process lipid biosynthetic process alcohol metabolic process primary metabolic process biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process small molecule metabolic process metabolic process cellular process isoprenoid metabolic process lipid metabolic process dolichol-linked oligosaccharide biosynthetic process carbohydrate derivative metabolic process phospholipid metabolic process protein N-linked glycosylation via asparagine phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process dolichyl diphosphate biosynthetic process carbohydrate derivative biosynthetic process dolichyl diphosphate metabolic process glycoprotein biosynthetic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process phospholipid biosynthetic process organophosphate metabolic process glycosylation organophosphate biosynthetic process macromolecule modification macromolecule glycosylation macromolecule metabolic process	protein-containing complex catalytic complex polyprenyl diphosphate synthase complex transferase complex dehydrodolichyl diphosphate synthase complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system protein-containing complex catalytic complex polyprenyl diphosphate synthase complex transferase complex dehydrodolichyl diphosphate synthase complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system organelle subcompartment membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR001441	Decaprenyl diphosphate synthase-like	Family
B	IPR038887	Dehydrodolichyl diphosphate synthase complex subunit Nus1	Family
B	IPR036424	Decaprenyl diphosphate synthase-like superfamily	Homologous Superfamily
A	IPR018520	Di-trans-poly-cis-decaprenylcistransferase-like, conserved site	Conserved Site
A	IPR036424	Decaprenyl diphosphate synthase-like superfamily	Homologous Superfamily
A	IPR001441	Decaprenyl diphosphate synthase-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q96E22	congenital disorder of glycosylation congenital disorder of glycosylation, type IAA melanoma breast cancer Crohn disease inborn errors of metabolism ovarian cancer cutaneous melanoma intellectual disability, autosomal dominant 55, with seizures pancreatic ductal adenocarcinoma endometriosis type 2 diabetes mellitus
A	Pharos: Q86SQ9	retinitis pigmentosa 59 retinitis pigmentosa cone-rod dystrophy ductal breast carcinoma in situ osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia congenital disorder of glycosylation epilepsy pancreatic intraductal papillary-mucinous carcinoma retinal degeneration developmental delay and seizures with or without movement abnormalities invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.