Annotations: 7SF4

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Methyltransf_33	e7sf4B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Methyltransf_33	ECOD (1.6)
A	Methyltransf_33	e7sf4A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Methyltransf_33	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF10017	Histidine-specific methyltransferase, SAM-dependent (Methyltransf_33)	Histidine-specific methyltransferase, SAM-dependent	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Histidine N-alpha-methyltransferase	L-histidine N(alpha)-methyltransferase activity transferase activity, transferring one-carbon groups transferase activity methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity catalytic activity catalytic activity, acting on a protein protein methyltransferase activity	methylation metabolic process cellular process ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide amino-acid betaine biosynthetic process oxoacid metabolic process small molecule biosynthetic process sulfur amino acid metabolic process modified amino acid biosynthetic process carboxylic acid metabolic process modified amino acid metabolic process organic acid metabolic process organic acid biosynthetic process ergothioneine metabolic process methylation metabolic process cellular process ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide amino-acid betaine biosynthetic process oxoacid metabolic process small molecule biosynthetic process sulfur amino acid metabolic process modified amino acid biosynthetic process carboxylic acid metabolic process modified amino acid metabolic process organic acid metabolic process organic acid biosynthetic process ergothioneine metabolic process amino-acid betaine metabolic process carboxylic acid biosynthetic process sulfur compound biosynthetic process biosynthetic process modified histidine biosynthetic process ergothioneine biosynthetic process sulfur compound metabolic process small molecule metabolic process sulfur amino acid biosynthetic process	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR019257	Histidine-specific methyltransferase, SAM-dependent methyltransferase domain	Domain
A, B	IPR017804	4-dimethylallyltryptophan N-methyltransferase easF	Family
A, B	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B	IPR035094	Histidine N-alpha-methyltransferase	Family
A, B	IPR032888	Histidine N-alpha-methyltransferase, Actinobacteria-type	Family
A, B	IPR051128	EgtD Methyltransferase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.