Annotations: 7Y4O

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Sema_1	e7y4oB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Sema_1	ECOD (1.6)
B	PSI_1	e7y4oB2	A: few secondary structure elements	X: Trefoil/Plexin domain-like (From Topology)	H: Trefoil/Plexin domain-like (From Topology)	T: Trefoil/Plexin domain-like	F: PSI_1	ECOD (1.6)
A	Sema_1	e7y4oA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Sema_1	ECOD (1.6)
A	PSI_1	e7y4oA2	A: few secondary structure elements	X: Trefoil/Plexin domain-like (From Topology)	H: Trefoil/Plexin domain-like (From Topology)	T: Trefoil/Plexin domain-like	F: PSI_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01437	Plexin repeat (PSI)	Plexin repeat	-	Family
A, B	PF01403	Sema domain (Sema)	Sema domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Semaphorin 6D	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity semaphorin receptor binding chemorepellent activity	muscle cell migration cell migration cellular process cell motility smooth muscle cell migration cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus semaphorin-plexin signaling pathway signaling biological regulation cell communication muscle cell migration cell migration cellular process cell motility smooth muscle cell migration cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus semaphorin-plexin signaling pathway signaling biological regulation cell communication signal transduction negative regulation of locomotion regulation of cell motility regulation of smooth muscle cell migration negative regulation of biological process negative regulation of smooth muscle cell migration regulation of locomotion regulation of cell migration negative regulation of cellular process negative regulation of cell motility locomotion negative regulation of cell migration multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development positive regulation of locomotion positive regulation of biological process positive regulation of cell migration positive regulation of cell motility positive regulation of cellular process immune response cell activation lymphocyte activation cell activation involved in immune response leukocyte activation immune effector process T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell T cell activation involved in immune response T cell activation immune system process leukocyte activation involved in immune response lymphocyte activation involved in immune response head development animal organ development brain development central nervous system development ventricular system development stem cell development neural crest cell differentiation neural crest cell development mesenchyme development tissue development mesenchymal cell migration stem cell differentiation ameboidal-type cell migration mesenchymal cell differentiation neural crest cell migration positive regulation of smooth muscle cell migration	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002165	Plexin repeat	Repeat
A, B	IPR036352	Sema domain superfamily	Homologous Superfamily
A, B	IPR001627	Sema domain	Domain
A, B	IPR027231	Semaphorin	Family
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.