Annotations: 8ROK

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF02463	RecF/RecN/SMC N terminal domain (SMC_N)	RecF/RecN/SMC N terminal domain	This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. T ...	This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1]. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D	Double-strand-break repair protein rad21 homolog	RNA binding binding organic cyclic compound binding lncRNA binding nucleic acid binding chromatin binding DNA binding transcription factor binding protein binding DNA-binding transcription factor binding	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process replication-born double-strand break repair via sister chromatid exchange cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process replication-born double-strand break repair via sister chromatid exchange cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process regulation of metabolic process homologous recombination sexual reproduction reproductive process meiotic cell cycle process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process meiotic cell cycle organelle fission reciprocal meiotic recombination nuclear division organelle organization meiosis I cell cycle process cell division regulation of cell cycle phase transition G2/M transition of mitotic cell cycle negative regulation of cell cycle cell cycle phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition regulation of cell cycle cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process regulation of cell cycle G2/M phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition chromosome segregation protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization apoptotic process cell death programmed cell death interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production chromosome organization sister chromatid cohesion positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process positive regulation of cell cycle process positive regulation of cellular process regulation of chromosome organization positive regulation of sister chromatid cohesion regulation of organelle organization positive regulation of cell cycle positive regulation of chromosome organization regulation of sister chromatid cohesion mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion establishment of sister chromatid cohesion neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process regulation of neuron apoptotic process chromatin looping chromatin organization interleukin-10 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of interleukin-10 production positive regulation of interleukin-10 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus establishment of meiotic sister chromatid cohesion meiotic sister chromatid cohesion regulation of glial cell apoptotic process negative regulation of glial cell apoptotic process glial cell apoptotic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process regulation of DNA-templated transcription regulation of mitotic nuclear division negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization mitotic sister chromatid separation negative regulation of sister chromatid segregation negative regulation of cellular component organization sister chromatid segregation regulation of mitotic sister chromatid segregation regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic metaphase/anaphase transition mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation mitotic nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle	midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix cytoskeleton spindle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane condensed nuclear chromosome nuclear chromosome chromosome condensed chromosome cytoplasm cytosol chromosome, centromeric region chromosomal region protein-containing complex mitotic cohesin complex cohesin complex nucleoplasm chromatin meiotic cohesin complex
A, C	Structural maintenance of chromosomes protein 3	chromatin binding binding microtubule motor activity cytoskeletal motor activity ATP-dependent activity protein heterodimerization activity protein binding protein dimerization activity protein-containing complex binding mediator complex binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding chromatin binding binding microtubule motor activity cytoskeletal motor activity ATP-dependent activity protein heterodimerization activity protein binding protein dimerization activity protein-containing complex binding mediator complex binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding double-stranded DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity cytoskeletal protein binding beta-tubulin binding tubulin binding dynein complex binding	cellular process cell cycle mitotic cell cycle cell division regulation of biological process regulation of cellular process biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA replication cellular process cell cycle mitotic cell cycle cell division regulation of biological process regulation of cellular process biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA replication metabolic process macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular component organization organelle organization chromosome organization sister chromatid cohesion cellular component organization or biogenesis cell cycle process mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion mitotic cell cycle process establishment of sister chromatid cohesion developmental process multicellular organismal process maintenance of cell number stem cell population maintenance cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress DNA repair establishment of meiotic sister chromatid cohesion meiotic sister chromatid cohesion microtubule cytoskeleton organization membraneless organelle assembly cellular component biogenesis cellular component assembly mitotic sister chromatid segregation chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization mitotic nuclear division organelle assembly organelle fission sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly nuclear division nuclear chromosome segregation microtubule-based process cytoskeleton organization sexual reproduction reproductive process meiotic cell cycle	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix cytoplasm membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix cytoplasm cytosol membraneless organelle chromosome, centromeric region intracellular membraneless organelle chromosome chromosomal region protein-containing complex mitotic cohesin complex cohesin complex nucleoplasm chromatin condensed nuclear chromosome nuclear chromosome lateral element synaptonemal structure synaptonemal complex condensed chromosome mitotic spindle spindle cytoskeleton mitotic spindle pole spindle pole microtubule cytoskeleton meiotic cohesin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR023093	ScpA-like, C-terminal	Homologous Superfamily
B, D	IPR049589	NXP-1, middle HEAT-repeat binding domain	Domain
B, D	IPR039781	Rad21/Rec8-like protein	Family
B, D	IPR006910	Rad21/Rec8-like protein, N-terminal	Domain
B, D	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B, D	IPR006909	Rad21/Rec8-like protein, C-terminal, eukaryotic	Domain
A, C	IPR041741	Structural maintenance of chromosomes 3, ABC domain, eukaryotic	Domain
A, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, C	IPR010935	SMCs flexible hinge	Domain
A, C	IPR036277	SMCs flexible hinge superfamily	Homologous Superfamily
A, C	IPR003395	RecF/RecN/SMC, N-terminal	Domain
A, C	IPR024704	Structural maintenance of chromosomes protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D	Pharos: O60216	Cornelia de Lange syndrome myeloid leukemia Leukemia, Megakaryoblastic, of Down Syndrome Cornelia de Lange syndrome 4 chronic monocytic leukemia intellectual disability lung carcinoma malignant mesothelioma medulloblastoma acute myeloid leukemia oligodendroglioma breast cancer rheumatoid arthritis colorectal adenoma endometrium carcinoma in situ Cornelia de Lange syndrome myeloid leukemia Leukemia, Megakaryoblastic, of Down Syndrome Cornelia de Lange syndrome 4 chronic monocytic leukemia intellectual disability lung carcinoma malignant mesothelioma medulloblastoma acute myeloid leukemia oligodendroglioma breast cancer rheumatoid arthritis colorectal adenoma endometrium carcinoma in situ invasive ductal breast carcinoma lung adenocarcinoma Mungan syndrome astrocytic tumor osteosarcoma primitive neuroectodermal tumor Roberts syndrome colorectal cancer Cornelia de Lange syndrome 2 glioblastoma large cell medulloblastoma lung cancer malignant ependymoma plasma cell myeloma atypical teratoid rhabdoid tumor colorectal adenocarcinoma trichorhinophalangeal syndrome type II congenital anemia Cornelia de Lange syndrome 3 endometrial carcinoma
A, C	Pharos: Q9UQE7	Cornelia de Lange syndrome Cornelia de Lange syndrome 3 myeloid leukemia chronic monocytic leukemia intellectual disability Neurodevelopmental Disorders psoriasis Roberts syndrome adrenal cortex carcinoma congenital anemia lung cancer medulloblastoma non-small cell lung carcinoma ovarian cancer primitive neuroectodermal tumor Cornelia de Lange syndrome Cornelia de Lange syndrome 3 myeloid leukemia chronic monocytic leukemia intellectual disability Neurodevelopmental Disorders psoriasis Roberts syndrome adrenal cortex carcinoma congenital anemia lung cancer medulloblastoma non-small cell lung carcinoma ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor malignant glioma osteogenesis imperfecta periodontitis progressive supranuclear palsy rheumatoid arthritis Cornelia de Lange syndrome 2 malignant mesothelioma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.