Annotations: 8RYS

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cytokine	8043267	3000648	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00340	Interleukin-1 / 18 (IL1)	Interleukin-1 / 18	This family includes interleukin-1 and interleukin-18.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Interleukin-1 beta	protein binding binding interleukin-1 receptor binding signaling receptor binding cytokine receptor binding growth factor receptor binding protein domain specific binding cell adhesion molecule binding protein-containing complex binding integrin binding molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity protein binding binding interleukin-1 receptor binding signaling receptor binding cytokine receptor binding growth factor receptor binding protein domain specific binding cell adhesion molecule binding protein-containing complex binding integrin binding molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process developmental process multicellular organismal process regulation of multicellular organismal development regulation of developmental process cellular developmental process cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development neurogenesis cell differentiation anatomical structure development regulation of multicellular organismal process system development cell chemotaxis cellular response to stimulus chemotaxis response to stimulus neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis immune system process granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion apoptotic process cell death programmed cell death regulation of localization hexose transmembrane transport regulation of transport transport negative regulation of D-glucose transmembrane transport negative regulation of biological process carbohydrate transport negative regulation of transport establishment of localization negative regulation of transmembrane transport transmembrane transport localization regulation of transmembrane transport D-glucose transmembrane transport negative regulation of cellular process regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport negative regulation of protein transport establishment of protein localization system process nitrogen compound transport negative regulation of adiponectin secretion regulation of adiponectin secretion cell communication adiponectin secretion negative regulation of secretion negative regulation of hormone secretion negative regulation of secretion by cell intracellular protein localization regulation of biological quality regulation of hormone levels establishment of protein localization to extracellular region negative regulation of establishment of protein localization protein secretion regulation of protein secretion regulation of secretion endocrine hormone secretion negative regulation of protein secretion negative regulation of multicellular organismal process regulation of hormone secretion regulation of protein localization signaling negative regulation of signaling hormone secretion negative regulation of cell communication protein localization to extracellular region secretion by cell regulation of secretion by cell signal release negative regulation of protein localization regulation of signaling secretion regulation of establishment of protein localization export from cell cell-cell signaling regulation of protein transport endocrine process protein transport macromolecule localization hormone transport regulation of cell communication regulation of cellular component organization negative regulation of cellular component organization gap junction assembly regulation of gap junction assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of cell junction assembly negative regulation of gap junction assembly cell junction organization cellular component assembly negative regulation of cell junction assembly cell junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization positive regulation of organelle organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle regulation of mitotic cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division positive regulation of interleukin-8 production positive regulation of macromolecule biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of interleukin-8 production astrocyte differentiation astrocyte activation glial cell development astrocyte development gliogenesis response to stress defense response cell activation central nervous system development glial cell differentiation glial cell activation inflammatory response neuroinflammatory response intracellular signal transduction JNK cascade intracellular signaling cassette MAPK cascade signal transduction reproductive process developmental process involved in reproduction programmed cell death involved in cell development ectopic germ cell programmed cell death positive regulation of cell adhesion regulation of cell adhesion positive regulation of cell-cell adhesion heterotypic cell-cell adhesion cell adhesion cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion cellular response to xenobiotic stimulus response to xenobiotic stimulus negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process negative regulation of cell development positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation positive regulation of lymphocyte activation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway positive regulation of response to stimulus enzyme-linked receptor protein signaling pathway positive regulation of platelet-derived growth factor receptor signaling pathway cell surface receptor signaling pathway platelet-derived growth factor receptor signaling pathway regulation of response to stimulus positive regulation of signaling positive regulation of canonical NF-kappaB signal transduction regulation of intracellular signal transduction positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction negative regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction in absence of ligand regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of apoptotic signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade immune response regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development positive regulation of developmental process positive regulation of cell differentiation animal organ development tissue development epithelial to mesenchymal transition mesenchymal cell differentiation fever generation acute-phase response homeostatic process heat generation multicellular organismal-level homeostasis temperature homeostasis acute inflammatory response macrophage derived foam cell differentiation foam cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation carbohydrate derivative biosynthetic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process hyaluronan biosynthetic process hyaluronan metabolic process aminoglycan metabolic process aminoglycan biosynthetic process glycosaminoglycan biosynthetic process multi-multicellular organism process female pregnancy embryo implantation multi-organism reproductive process positive regulation of cell adhesion molecule production regulation of cell adhesion molecule production cell adhesion molecule production negative regulation of intracellular signal transduction negative regulation of MAPK cascade RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction p38MAPK cascade positive regulation of p38MAPK cascade regulation of p38MAPK cascade muscle adaptation smooth muscle adaptation muscle system process response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to interleukin-1 interleukin-1-mediated signaling pathway cellular response to cytokine stimulus response to interleukin-1 regulation of prostaglandin secretion monocarboxylic acid transport fatty acid transport prostaglandin secretion positive regulation of icosanoid secretion carboxylic acid transport lipid transport regulation of fatty acid transport organic acid transport positive regulation of lipid transport lipid export from cell prostaglandin transport regulation of lipid transport positive regulation of secretion by cell positive regulation of secretion icosanoid transport regulation of icosanoid secretion positive regulation of prostaglandin secretion icosanoid secretion organic anion transport lipid localization positive regulation of lipid localization positive regulation of organic acid transport positive regulation of transport regulation of lipid localization regulation of organic acid transport positive regulation of fatty acid transport positive regulation of nervous system development regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of glial cell proliferation positive regulation of neurogenesis positive regulation of cell development glial cell proliferation regulation of molecular function regulation of catalytic activity regulation of nitric-oxide synthase activity regulation of oxidoreductase activity biological process involved in interspecies interaction between organisms response to lipid response to other organism response to oxygen-containing compound response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin regulation of type II interferon production type II interferon production positive regulation of type II interferon production response to carbohydrate regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus regulation of defense response to virus defense response to virus regulation of response to stress regulation of defense response to virus by host response to virus adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity T cell cytokine production positive regulation of immune response T-helper 1 cell cytokine production leukocyte mediated immunity positive regulation of adaptive immune response positive regulation of T cell cytokine production regulation of T cell mediated immunity regulation of cytokine production involved in immune response regulation of adaptive immune response T-helper 1 type immune response regulation of T-helper 1 type immune response immune effector process regulation of leukocyte mediated immunity positive regulation of production of molecular mediator of immune response regulation of immune response regulation of production of molecular mediator of immune response positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of T-helper 1 cell cytokine production regulation of T-helper 1 cell cytokine production regulation of T cell cytokine production CD4-positive, alpha-beta T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune effector process cytokine production involved in immune response production of molecular mediator of immune response positive regulation of T-helper 1 type immune response adaptive immune response regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response cellular response to interleukin-17 response to interleukin-17 regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response positive regulation of defense response cellular response to growth factor stimulus regulation of vascular endothelial growth factor receptor signaling pathway cellular response to endogenous stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus vascular endothelial growth factor receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway response to growth factor regulation of humoral immune response humoral immune response complement activation positive regulation of humoral immune response positive regulation of complement activation regulation of complement activation activation of immune response positive regulation of cell division cell division regulation of cell division monocyte aggregation leukocyte aggregation cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway regulation of cellular response to insulin stimulus response to hormone cellular response to hormone stimulus regulation of insulin receptor signaling pathway cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound negative regulation of cellular response to insulin stimulus negative regulation of insulin receptor signaling pathway response to insulin cellular response to insulin stimulus prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process regulation of lipid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process regulation of small molecule metabolic process positive regulation of lipid metabolic process positive regulation of prostaglandin biosynthetic process small molecule metabolic process prostaglandin biosynthetic process regulation of ketone metabolic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process monocarboxylic acid metabolic process positive regulation of unsaturated fatty acid biosynthetic process regulation of prostaglandin biosynthetic process icosanoid metabolic process ketone metabolic process regulation of unsaturated fatty acid biosynthetic process lipid biosynthetic process positive regulation of fatty acid biosynthetic process prostanoid metabolic process icosanoid biosynthetic process prostanoid biosynthetic process positive regulation of fatty acid metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process positive regulation of lipid biosynthetic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process lipid metabolic process positive regulation of JNK cascade regulation of JNK cascade regulation of peptide secretion peptide secretion amide transport regulation of peptide hormone secretion regulation of peptide transport peptide transport regulation of insulin secretion peptide hormone secretion insulin secretion cellular component disassembly regulation of tight junction disassembly cell junction disassembly tight junction organization positive regulation of tight junction disassembly tight junction disassembly cell-cell junction disassembly negative regulation of metabolic process negative regulation of lipid metabolic process trans-synaptic signaling modulation of chemical synaptic transmission negative regulation of synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling negative regulation of catabolic process lipid catabolic process catabolic process regulation of catabolic process regulation of lipid catabolic process negative regulation of lipid catabolic process positive regulation of protein metabolic process positive regulation of membrane protein ectodomain proteolysis macromolecule catabolic process regulation of proteolysis proteolysis membrane protein proteolysis protein metabolic process membrane protein ectodomain proteolysis regulation of membrane protein ectodomain proteolysis regulation of protein metabolic process protein catabolic process positive regulation of protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of protein catabolic process mononuclear cell differentiation lymphocyte differentiation T cell differentiation in thymus regulation of immature T cell proliferation T cell differentiation positive regulation of immature T cell proliferation regulation of immature T cell proliferation in thymus leukocyte differentiation immature T cell proliferation in thymus positive regulation of immature T cell proliferation in thymus hemopoiesis immature T cell proliferation positive regulation of DNA-templated transcription DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production cellular response to lipopolysaccharide cellular response to molecule of bacterial origin cellular response to biotic stimulus cellular response to lipid positive regulation of lipid catabolic process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of monocyte chemotactic protein-1 production positive regulation of monocyte chemotactic protein-1 production monocyte chemotactic protein-1 production regulation of chemokine production chemokine production positive regulation of chemokine production cellular localization nucleocytoplasmic transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization positive regulation of protein transport establishment of localization in cell positive regulation of intracellular transport nuclear export regulation of protein export from nucleus regulation of intracellular transport intracellular transport regulation of nucleocytoplasmic transport protein export from nucleus positive regulation of protein export from nucleus regulation of cellular localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport negative regulation of cell population proliferation angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis regulation of interleukin-2 production interleukin-2 production positive regulation of interleukin-2 production response to organophosphorus response to ATP response to purine-containing compound granulocyte macrophage colony-stimulating factor production positive regulation of granulocyte macrophage colony-stimulating factor production regulation of granulocyte macrophage colony-stimulating factor production regulation of establishment of endothelial barrier endothelium development epithelial cell differentiation regulation of epithelial cell differentiation endothelial cell development regulation of endothelial cell development epithelium development endothelial cell differentiation regulation of endothelial cell differentiation epithelial cell development establishment of endothelial barrier positive regulation of neuroinflammatory response regulation of neuroinflammatory response regulation of heat generation positive regulation of heat generation positive regulation of acute inflammatory response positive regulation of fever generation regulation of acute inflammatory response regulation of fever generation defense response to Gram-positive bacterium defense response to bacterium	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol extracellular region extracellular space membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome intracellular vesicle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol extracellular region extracellular space membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020877	Interleukin-1 conserved site	Conserved Site
A	IPR008996	Cytokine IL1/FGF	Homologous Superfamily
A	IPR000975	Interleukin-1 family	Family
A	IPR003502	Interleukin-1 propeptide	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P01584	psoriasis glioblastoma ulcerative colitis neutropenia cancer gout colitis polymyositis Kearns-Sayre syndrome Leber hereditary optic neuropathy bronchopulmonary dysplasia MELAS syndrome anthracosis gastric ulcer cardiomyopathy psoriasis glioblastoma ulcerative colitis neutropenia cancer gout colitis polymyositis Kearns-Sayre syndrome Leber hereditary optic neuropathy bronchopulmonary dysplasia MELAS syndrome anthracosis gastric ulcer cardiomyopathy asthma silicosis pneumonia Alzheimer disease rheumatoid arthritis hypertensive disorder dermatomyositis MERRF syndrome peptic ulcer disease glomerulonephritis hemolytic-uremic syndrome myopathy allergic disease pulmonary fibrosis HIV wasting syndrome Fibrosis visceral leishmaniasis hypoglycemia giant cell glioblastoma middle cerebral artery infarction pleurisy malignant colon neoplasm skin disease bipolar disorder heart valve disease congestive heart failure postmenopausal osteoporosis coronary artery disease breast cancer tuberculosis hereditary diffuse gastric adenocarcinoma cutaneous leishmaniasis gastric cancer leukopenia schizophrenia visual epilepsy cerebrovascular disorder granular cell carcinoma lymphopenia adenocarcinoma thyroid gland carcinoma extrahepatic cholestasis brain ischemia trigeminal neuralgia breast carcinoma manganese poisoning tubular adenocarcinoma calcinosis urticaria inborn mitochondrial myopathy chronic atrophic gastritis thyroid adenoma multiple sclerosis myocardial infarction progressive external ophthalmoplegia pyogenic arthritis-pyoderma gangrenosum-acne syndrome cystic fibrosis non-small cell lung carcinoma gastric neoplasm vasculitis hyperglycemia dermatitis, atopic liver disease gastrointestinal mucositis diarrheal disease arthritic joint disease mevalonic aciduria idiopathic interstitial pneumonia periodontitis lung cancer synovitis acne infectious meningitis pilocytic astrocytoma lymphatic system disease thrombotic disease chronic obstructive pulmonary disease influenza Barrett esophagus thyroid cancer heart disease malignant mesothelioma ischemia reperfusion injury brain injury toxic encephalopathy myocardial ischemia learning disability cribriform carcinoma of breast allergic rhinitis alopecia areata type 2 diabetes mellitus dementia non-alcoholic fatty liver disease osteoarthritis pancreatitis lung adenocarcinoma inborn carbohydrate metabolic disorder peripheral neuropathy lung carcinoma atopic eczema head and neck cancer mood disorder inherited disease susceptibility benign colon neoplasm malignant ependymoma heart failure colonic neoplasm muscle tissue disease adenoma interstitial cystitis sleep-wake disorder kidney disease malignant pancreatic neoplasm COVID-19 familial Mediterranean fever pulmonary edema HIV infectious disease Crohn disease pustulosis palmaris et plantaris burn cutaneous lupus erythematosus neurodegenerative disease gastric carcinoma depressive disorder obesity disorder osteoarthritis susceptibility 1 hypotensive disorder lung benign neoplasm drug-induced liver injury peritonitis atherosclerosis endometriosis autoimmune disease major depressive disorder inherited lipid metabolism disorder epilepsy pneumonitis benign neoplasm malignant glioma muscular disease adult acute respiratory distress syndrome interstitial lung disease juvenile dermatomyositis exocrine pancreatic carcinoma eye disease hepatocellular carcinoma cribriform carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.