8V4X | pdb_00008v4x

Structure of MALT1 in complex with an allosteric inhibitor

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00656	Caspase domain (Peptidase_C14)	Caspase domain		Domain
A, B, C, D, E A, B, C, D, E, F	PF18703	MALT1 Ig-like domain (MALT1_Ig)	MALT1 Ig-like domain	This is an Immunoglobulin like domain which can be found in the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase. Malt1 is a key component of the Carma1/Bcl10/MALT1 signalosome and is critical for NF-kB signaling in mult ...	This is an Immunoglobulin like domain which can be found in the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase. Malt1 is a key component of the Carma1/Bcl10/MALT1 signalosome and is critical for NF-kB signaling in multiple contexts. The MALT1 C-terminal Ig domain is suggested to recruit key factors to promote NF-kB activation. The It is also proposed to undergo Lys63-linked ubiquitylation via TRAF6 in potentially nine different lysines to recruit the IKK complex [1 , 2, 3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
G, H, I, J, K G, H, I, J, K, L	Inhibitor peptide	-	-	-
A, B, C, D, E A, B, C, D, E, F	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	binding small molecule binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity identical protein binding protein binding cysteine-type peptidase activity cysteine-type endopeptidase activity enzyme binding protease binding aminoacyltransferase activity binding small molecule binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity identical protein binding protein binding cysteine-type peptidase activity cysteine-type endopeptidase activity enzyme binding protease binding aminoacyltransferase activity ubiquitin-like protein transferase activity acyltransferase activity transferase activity ubiquitin-protein transferase activity endopeptidase activator activity enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity endopeptidase regulator activity	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response cytokine production leukocyte mediated immunity adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response cytokine production leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production positive regulation of immune system process regulation of T cell mediated immunity regulation of biological process regulation of cytokine production involved in immune response immune response regulation of adaptive immune response immune effector process regulation of gene expression regulation of leukocyte mediated immunity biosynthetic process regulation of response to stimulus positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus regulation of T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process regulation of multicellular organismal process cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process adaptive immune response regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response cellular process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway signaling regulation of antigen receptor-mediated signaling pathway regulation of signal transduction cell communication immune response-activating signaling pathway immune response-regulating signaling pathway signal transduction regulation of signaling cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway regulation of T cell receptor signaling pathway T cell receptor signaling pathway regulation of cell communication antigen receptor-mediated signaling pathway activation of immune response B cell activation cell activation lymphocyte activation leukocyte activation biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus catabolic process proteolysis involved in protein catabolic process proteolysis primary metabolic process protein catabolic process protein metabolic process macromolecule catabolic process response to fungus regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport nuclear export establishment of localization cell population proliferation leukocyte proliferation mononuclear cell proliferation T cell activation lymphocyte proliferation T cell proliferation positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of signaling developmental process cellular developmental process hemopoiesis cell development mononuclear cell differentiation mature B cell differentiation lymphocyte differentiation B-1 B cell differentiation B cell differentiation cell differentiation anatomical structure development leukocyte differentiation negative regulation of programmed cell death negative regulation of biological process negative regulation of apoptotic process negative regulation of cellular process response to lipid cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical cellular response to lipid response to molecule of bacterial origin regulation of protein modification process positive regulation of protein metabolic process regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of protein modification process protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification regulation of protein metabolic process macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of interleukin-2 production interleukin-2 production positive regulation of interleukin-2 production regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation positive regulation of T cell differentiation regulation of cell development alpha-beta T cell differentiation involved in immune response multicellular organism development regulation of T-helper cell differentiation alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell differentiation T-helper cell differentiation positive regulation of cell development regulation of leukocyte cell-cell adhesion T-helper 17 cell differentiation positive regulation of alpha-beta T cell differentiation regulation of developmental process positive regulation of leukocyte cell-cell adhesion CD4-positive, alpha-beta T cell differentiation positive regulation of T-helper 17 cell differentiation positive regulation of T-helper cell differentiation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation alpha-beta T cell differentiation T cell activation involved in immune response positive regulation of cell differentiation leukocyte activation involved in immune response regulation of cell-cell adhesion regulation of T-helper 17 cell differentiation regulation of cell adhesion positive regulation of T-helper 17 type immune response regulation of CD4-positive, alpha-beta T cell activation regulation of lymphocyte activation regulation of leukocyte differentiation regulation of cell differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation involved in immune response positive regulation of developmental process positive regulation of cell activation positive regulation of leukocyte activation T cell differentiation positive regulation of T cell activation positive regulation of alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation leukocyte cell-cell adhesion positive regulation of CD4-positive, alpha-beta T cell activation cell adhesion cell-cell adhesion alpha-beta T cell activation involved in immune response positive regulation of hemopoiesis CD4-positive, alpha-beta T cell activation lymphocyte activation involved in immune response regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of T-helper 17 type immune response positive regulation of cell adhesion regulation of T cell activation T cell differentiation involved in immune response regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation T-helper 17 type immune response	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex polkadots CBM complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex polkadots CBM complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen fibrillar center organelle membraneless organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR003599	Immunoglobulin domain subtype	Domain
A, B, C, D, E A, B, C, D, E, F	IPR037940	MALT1, death domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR007110	Immunoglobulin-like domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR041077	MALT1 immunoglobulin-like domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR052039	Caspase-related proteases and regulators	Family
A, B, C, D, E A, B, C, D, E, F	IPR001309	Peptidase C14, p20 domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR003598	Immunoglobulin subtype 2	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011600	Peptidase C14, caspase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR033540	MALT1, immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR011029	Death-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9UDY8	combined immunodeficiency due to MALT1 deficiency diffuse large B-cell lymphoma MALT lymphoma Nasal discharge primitive neuroectodermal tumor subependymal giant cell astrocytoma allergic rhinitis atypical teratoid rhabdoid tumor familial dermatographia lung cancer malignant glioma medulloblastoma osteosarcoma psoriasis urticaria combined immunodeficiency due to MALT1 deficiency diffuse large B-cell lymphoma MALT lymphoma Nasal discharge primitive neuroectodermal tumor subependymal giant cell astrocytoma allergic rhinitis atypical teratoid rhabdoid tumor familial dermatographia lung cancer malignant glioma medulloblastoma osteosarcoma psoriasis urticaria angioedema gastric carcinoma glioblastoma lymphoma ovarian cancer atopic conjunctivitis Gaucher disease malignant ependymoma marginal zone lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.