Annotations: 8VDD

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B	MH2 HLA-DQ8	II-ALPHA	Homo sapiens (human)	HLA-DQB1*0302	G-DOMAIN G-ALPHA, C-LIKE-DOMAIN C-LIKE	MH	II-ALPHA	IMGT (202604-0)
A	MH2 HLA-DQ8	II-ALPHA	Homo sapiens (human)	HLA-DQA10301, HLA-DQA10302, HLA-DQA1*0303	G-DOMAIN G-ALPHA, C-LIKE-DOMAIN C-LIKE	MH	II-ALPHA	IMGT (202604-0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C	Proinsulin C-peptide (InsC8-22)	protein binding binding signaling receptor binding insulin receptor binding identical protein binding insulin-like growth factor receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity enzyme binding protease binding hormone activity	negative regulation of protein transport regulation of localization establishment of protein localization regulation of cellular process regulation of protein localization transport negative regulation of biological process negative regulation of transport protein localization to extracellular region localization regulation of secretion by cell secretion by cell negative regulation of secretion negative regulation of cellular process negative regulation of protein transport regulation of localization establishment of protein localization regulation of cellular process regulation of protein localization transport negative regulation of biological process negative regulation of transport protein localization to extracellular region localization regulation of secretion by cell secretion by cell negative regulation of secretion negative regulation of cellular process negative regulation of secretion by cell intracellular protein localization negative regulation of protein localization regulation of biological process regulation of transport secretion biological regulation regulation of establishment of protein localization establishment of protein localization to extracellular region negative regulation of establishment of protein localization export from cell regulation of protein transport protein secretion establishment of localization regulation of protein secretion regulation of secretion negative regulation of protein secretion protein transport macromolecule localization cellular process negative regulation of small molecule metabolic process oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process organic acid metabolic process regulation of primary metabolic process regulation of small molecule metabolic process small molecule metabolic process fatty acid metabolic process negative regulation of fatty acid metabolic process negative regulation of metabolic process carboxylic acid metabolic process primary metabolic process regulation of ketone metabolic process regulation of fatty acid metabolic process metabolic process monocarboxylic acid metabolic process regulation of metabolic process negative regulation of lipid metabolic process lipid metabolic process positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function regulation of catalytic activity regulation of nitric-oxide synthase activity positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process macromolecule metabolic process positive regulation of cellular process signaling cell-cell signaling cell communication multicellular organismal process system process nervous system process cognition developmental process regulation of developmental process cellular developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation T cell activation immune system process cell activation alpha-beta T cell activation lymphocyte activation leukocyte activation positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process glucose metabolic process regulation of neuron projection development cell projection organization cell development neuron projection development neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development anatomical structure development positive regulation of cell projection organization system development plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization cellular response to stimulus cellular response to nitrogen compound positive regulation of cell communication positive regulation of signal transduction response to stimulus response to peptide hormone regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus regulation of signaling cell surface receptor signaling pathway response to endogenous stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus regulation of response to stimulus response to chemical response to insulin regulation of cell communication cellular response to insulin stimulus positive regulation of signaling positive regulation of respiratory burst respiratory burst regulation of respiratory burst RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of DNA-templated transcription acute-phase response defense response response to stress inflammatory response acute inflammatory response nitric oxide mediated signal transduction intracellular signal transduction nitric oxide-cGMP-mediated signaling intracellular signaling cassette catabolic process energy derivation by oxidation of organic compounds carbohydrate catabolic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process macromolecule catabolic process glucan metabolic process polysaccharide metabolic process regulation of glycogen catabolic process glycogen catabolic process regulation of carbohydrate metabolic process negative regulation of carbohydrate metabolic process negative regulation of glycogen metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of carbohydrate catabolic process glucan catabolic process glycogen metabolic process generation of precursor metabolites and energy regulation of catabolic process negative regulation of glycogen catabolic process polysaccharide catabolic process energy reserve metabolic process regulation of glycogen metabolic process negative regulation of protein catabolic process protein metabolic process negative regulation of protein metabolic process regulation of protein metabolic process protein catabolic process regulation of protein catabolic process protein localization to cell periphery cellular localization protein localization to plasma membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization regulation of protein localization to plasma membrane regulation of protein localization to membrane lipid catabolic process regulation of lipid catabolic process negative regulation of lipid catabolic process nitrogen compound transport regulation of hormone secretion regulation of peptide secretion positive regulation of secretion by cell hormone secretion peptide secretion positive regulation of hormone secretion positive regulation of secretion signal release regulation of biological quality regulation of peptide hormone secretion positive regulation of peptide secretion regulation of hormone levels positive regulation of peptide hormone secretion regulation of peptide transport peptide transport positive regulation of transport peptide hormone secretion hormone transport chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis regulation of growth growth positive regulation of cell growth regulation of cell growth cell growth positive regulation of growth positive regulation of canonical NF-kappaB signal transduction regulation of intracellular signal transduction positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus protein localization to organelle positive regulation of protein localization ribonucleotide catabolic process pyridine nucleotide catabolic process aerobic respiration carbohydrate derivative metabolic process organophosphate catabolic process positive regulation of phosphate metabolic process nucleoside phosphate catabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process positive regulation of nucleotide catabolic process glycolytic process regulation of nucleotide metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process positive regulation of phosphorus metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of phosphorus metabolic process regulation of nucleotide catabolic process positive regulation of carbohydrate metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process cellular respiration ATP metabolic process positive regulation of nucleotide metabolic process positive regulation of purine nucleotide catabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process ADP catabolic process regulation of glycolytic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of catabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process positive regulation of small molecule metabolic process purine ribonucleoside diphosphate catabolic process modulation of chemical synaptic transmission long-term synaptic potentiation synaptic signaling positive regulation of long-term synaptic potentiation regulation of synaptic plasticity trans-synaptic signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of nitric oxide mediated signal transduction positive regulation of nitric oxide mediated signal transduction reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process negative regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species biosynthetic process negative regulation of biosynthetic process regulation of reactive oxygen species metabolic process positive regulation of glycogen metabolic process carbohydrate biosynthetic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process regulation of glycogen biosynthetic process glucan biosynthetic process regulation of glucan biosynthetic process regulation of glucose metabolic process polysaccharide biosynthetic process glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process dendritic spine maintenance cellular component maintenance regulation of dendritic spine maintenance positive regulation of dendritic spine maintenance regulation of synapse structure or activity synapse organization dendritic spine organization postsynapse organization regulation of postsynapse organization regulation of synapse organization cell junction organization neuron projection organization lipid biosynthetic process positive regulation of lipid biosynthetic process positive regulation of lipid metabolic process regulation of lipid biosynthetic process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation regulation of tube diameter regulation of tube size circulatory system process vascular process in circulatory system blood vessel diameter maintenance vasodilation blood circulation regulation of anatomical structure size positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of protein secretion fatty acid homeostasis lipid homeostasis intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of signaling negative regulation of intracellular signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway cell death negative regulation of signal transduction apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway fat cell differentiation positive regulation of brown fat cell differentiation positive regulation of fat cell differentiation regulation of brown fat cell differentiation brown fat cell differentiation regulation of fat cell differentiation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion regulation of defense response negative regulation of acute inflammatory response regulation of response to external stimulus negative regulation of inflammatory response response to external stimulus regulation of inflammatory response negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response regulation of acute inflammatory response wound healing response to wounding regulation of immune effector process response to biotic stimulus regulation of cell development regulation of respiratory burst involved in inflammatory response regulation of immune system process respiratory burst involved in defense response immune response response to other organism regulation of innate immune response negative regulation of immune response negative regulation of immune effector process immune effector process defense response to other organism respiratory burst involved in inflammatory response regulation of immune response negative regulation of respiratory burst involved in inflammatory response negative regulation of multicellular organismal process regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus negative regulation of respiratory burst innate immune response regulation of multicellular organismal process response to external biotic stimulus production of molecular mediator involved in inflammatory response defense response to symbiont negative regulation of immune system process negative regulation of innate immune response gluconeogenesis negative regulation of gluconeogenesis small molecule biosynthetic process monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis cytokine production regulation of cytokine production positive regulation of multicellular organismal process positive regulation of cytokine production G protein-coupled receptor signaling pathway negative regulation of gene expression negative regulation of macromolecule biosynthetic process import into cell hexose transmembrane transport regulation of D-glucose import across plasma membrane carbohydrate import across plasma membrane carbohydrate transport positive regulation of D-glucose transmembrane transport hexose import across plasma membrane positive regulation of transmembrane transport positive regulation of D-glucose import across plasma membrane import across plasma membrane transmembrane transport regulation of transmembrane transport D-glucose import across plasma membrane D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport negative regulation of feeding behavior negative regulation of behavior feeding behavior regulation of behavior behavior regulation of feeding behavior neuron projection maintenance	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle cellular anatomical structure organelle lumen organelle endoplasmic reticulum cytoplasm Golgi membrane membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle cellular anatomical structure organelle lumen organelle endoplasmic reticulum cytoplasm Golgi membrane Golgi apparatus membrane bounding membrane of organelle organelle membrane endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment extracellular region extracellular space transport vesicle intracellular vesicle cytoplasmic vesicle vesicle Golgi lumen vesicle lumen cytoplasmic vesicle lumen secretory granule lumen secretory granule secretory vesicle endosome endosome lumen
B	MHC class II HLA-DQ-beta-1	-	antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process response to stimulus immune response adaptive immune response	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle
A	MHC class II HLA-DQ-alpha chain	-	antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process response to stimulus immune response adaptive immune response	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C	IPR004825	Insulin	Family
C	IPR022353	Insulin, conserved site	Conserved Site
C	IPR036438	Insulin-like superfamily	Homologous Superfamily
C	IPR016179	Insulin-like	Domain
C	IPR022352	Insulin/IGF/relaxin	Family
B	IPR000353	MHC class II, beta chain, N-terminal	Domain
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
B	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
B	IPR003597	Immunoglobulin C1-set	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
A	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
A	IPR003597	Immunoglobulin C1-set	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR001003	MHC class II, alpha chain, N-terminal	Domain
A	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C	Pharos: P01308	maturity-onset diabetes of the young type 1 diabetes mellitus 2 hyperproinsulinemia metabolic syndrome X hyperinsulinism maturity-onset diabetes of the young type 10 pancreatitis polycystic ovary syndrome obesity disorder myopathy hypertrophic cardiomyopathy Insulin Resistance type 2 diabetes mellitus glucose intolerance hyperglycemia maturity-onset diabetes of the young type 1 diabetes mellitus 2 hyperproinsulinemia metabolic syndrome X hyperinsulinism maturity-onset diabetes of the young type 10 pancreatitis polycystic ovary syndrome obesity disorder myopathy hypertrophic cardiomyopathy Insulin Resistance type 2 diabetes mellitus glucose intolerance hyperglycemia hypertensive disorder hypoglycemia type 1 diabetes mellitus Alzheimer disease diabetes mellitus rhabdomyolysis bipolar disorder hypertriglyceridemia metabolic disease congestive heart failure permanent neonatal diabetes mellitus 1 urinary bladder disease potassium deficiency disease kidney failure prostate cancer Lewy body dementia liver disease panic disorder Phelan-McDermid syndrome visual epilepsy hepatitis diabetic ketoacidosis cardiac arrest Parkinson disease acute liver failure permanent neonatal diabetes mellitus cystic kidney disease neural tube defect ventricular fibrillation hyperaldosteronism lung disease diabetic kidney disease diarrheal disease palsy pancreatic intraductal papillary-mucinous neoplasm skin disease cognitive disorder acromegaly hypothyroidism muscular disease peripheral neuropathy iniencephaly coronary artery disease gestational diabetes DEND syndrome neurodegenerative disease arthritic joint disease hyperandrogenism autoimmune disease osteoporosis hyperinsulinemic hypoglycemia blindness (disorder) maturity-onset diabetes of the young type 1 diastematomyelia pancreatic insulinoma cancer eating disorder pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cerebrovascular disorder sleep-wake disorder acquired metabolic disease infertility disorder tethered spinal cord syndrome peripheral vascular disease craniorachischisis neonatal diabetes mellitus neurenteric cyst prediabetes syndrome heart disease anemia prostate carcinoma lipodystrophy atherosclerosis autonomic neuropathy diabetic retinopathy breast disease pancreatic intraductal papillary-mucinous carcinoma metabolic acidosis cervical cancer hypotensive disorder muscle tissue disease acute kidney failure inherited lipid metabolism disorder fatty liver disease kidney disease dementia non-alcoholic fatty liver disease heart failure anovulation