8X7F

CryoEM structure of the trifunctional NAD biosynthesis/regulator protein NadR in complex with NAD

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C [auth G], D [auth J]	PF13521	AAA domain (AAA_28)	AAA domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C [auth G], D [auth J]	Trifunctional NAD biosynthesis/regulator protein NadR	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding ribosylnicotinamide kinase activity kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding cis-regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding adenylyltransferase activity nicotinamide-nucleotide adenylyltransferase activity nucleotidyltransferase activity identical protein binding protein binding	protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis response to stimulus response to pH response to alkaline pH protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis response to stimulus response to pH response to alkaline pH response to abiotic stimulus cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to metal ion response to chemical nucleotide biosynthetic process NAD metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process NAD biosynthetic process pyridine nucleotide biosynthetic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyridine-containing compound biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process nicotinamide nucleotide biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process purine nucleotide biosynthetic process phosphorylation	cell periphery cellular anatomical structure plasma membrane membrane protein-containing complex catalytic complex intracellular anatomical structure cytoplasm transferase complex, transferring phosphorus-containing groups adenylyltransferase complex transferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C [auth G], D [auth J]	IPR004821	Cytidyltransferase-like domain	Domain
A, B [auth D], C [auth G], D [auth J]	IPR001387	Cro/C1-type helix-turn-helix domain	Domain
A, B [auth D], C [auth G], D [auth J]	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily
A, B [auth D], C [auth G], D [auth J]	IPR052735	Bacterial NAD biosynthesis/regulator protein	Family
A, B [auth D], C [auth G], D [auth J]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B [auth D], C [auth G], D [auth J]	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily
A, B [auth D], C [auth G], D [auth J]	IPR006417	Nicotinamide-nucleotide adenylyltransferase	Domain
A, B [auth D], C [auth G], D [auth J]	IPR041749	NadR, nicotinamide/nicotinate mononucleotide adenylyltransferase domain	Domain
A, B [auth D], C [auth G], D [auth J]	IPR038727	NadR/Ttd14, AAA domain	Domain
A, B [auth D], C [auth G], D [auth J]	IPR016429	NAD biosynthesis/regulator protein NadR	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.